PMID: identifiant
de la référence Pubmed : |
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 (21346185)  |
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| titre : |
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Metabolic syndrome and onset of depressive symptoms in the elderly: findings from the three-city study. |
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| auteur(s) : |
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Tasnime Akbaraly ( ) 1, 2, Marie-Laure Ancelin1, Isabelle Jaussent1, Craig Ritchie3, Pascale Barberger-Gateau4, Carole Dufouil5, Mika Kivimaki2, Claudine Berr1, 6, Karen Ritchie1, 3 |
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| laboratoire : |
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| titre abrégé : |
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Metabolic Syndrome and depression in elderly |
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| résumé : |
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OBJECTIVE Given the increasing prevalence of both metabolic syndrome (MetS) and depressive symptoms during old age, we aimed to examine prospectively the association between MetS and the onset of depressive symptoms according to different age-groups in a large, general elderly population. RESEARCH DESIGN AND METHODS This was a prospective cohort study of 4,446 men and women aged 65-91 years who were free of depression or depressive symptoms at baseline (the Three-City Study, France). MetS was defined using the National Cholesterol Education Program Adult Treatment Panel III criteria. New onset of depressive symptoms (the Center for Epidemiologic Studies Depression Scale score ≥16 and use of antidepressant treatment) was assessed at 2- and 4-year follow-ups. RESULTS After adjusting for a large range of potential confounders, we observed MetS to be associated with 1.73-fold (95% CI 1.02-2.95) odds for new-onset depressive symptoms in the youngest age-group (65-70 years at baseline), independently of cardiovascular diseases. No such association was seen in older age-groups. CONCLUSIONS Our findings suggest that the link between MetS and depressive symptoms evidenced until now in middle-aged people can be extended to older adults but not to the oldest ones. Additional research is needed to examine if a better management of MetS prevents depressive symptoms in people aged 65-70 years. |
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| domaine : |
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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1935-5548 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.2337/dc10-1644 |
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| journal : |
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| Diabetes Care (Diabetes Care) |
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American Diabetes Association |
| ISSN |
0149-5992 (eISSN : 0149-5992) |
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| Audience : |
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internationale |
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| date de publication : |
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04/2011 |
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date de publication
électronique : |
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23/02/2011 |
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| volume : |
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34 |
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| numéro : |
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4 |
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| page, identifiant, ... : |
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904-9 |
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| mots-clés auteur : |
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Depressive symptoms – metabolic syndrome – elderly – prospective study |
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| contrat, financement : |
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The 3C Study is conducted under a partnership agreement between the Institut National de la Santé et de la Recherche Médicale (INSERM), Victor-Segalen Bordeaux-2 University, and Sanofi- Aventis. The Fondation pour la Recherche Médicale funded the preparation and initiation of the study. The 3C Study is also supported by the Caisse Nationale Maladie des Travailleurs Salariés, Direction Générale de la Santé, MGEN, Institut de la Longévité, Conseils Régionaux d‟Aquitaine et Bourgogne, Fondation de France and Ministry of Research - INSERM Programme "Cohortes et collections de données biologiques‟. Part of this project is financed by grant from the Agence Nationale de la Recherche (project ANR-2006-PNRA -005; ANR2007 LVIE 003;ANR 2007-LVIE- 004).Tasnime Akbaraly is supported by the BUPA Foundation, UK. Mika Kivimäki is supported by the Academy of Finland, Finland, the BUPA Foundation, the UK, and the inserm-00588145, version 1 - 22 Apr 2011 13 National Heart, Lung, and Blood Institute (R01HL036310-20A2) and the National Institute on Aging (R01AG034454-01), NIH, US. |
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| Projet ANR : |
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8953 |
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