Cathepsin-D, a key protease in breast cancer, is up-regulated in obese mouse and human adipose tissue, and controls adipogenesis.: Cathepsin D, adipogenesis and obesity

Abstract : The aspartic protease cathepsin-D (cath-D) is overexpressed by human epithelial breast cancer cells and is closely correlated with poor prognosis in breast cancer. The adipocyte is one of the most prominent cell types in the tumor-microenvironment of breast cancer, and clinical studies have shown that obesity increases the incidence of breast cancer. Here, we provide the first evidence that cath-D expression is up-regulated in adipose tissue from obese human beings, as well as in adipocytes from the obese C57BI6/J mouse. Cath-D expression is also increased during human and mouse adipocyte differentiation. We show that cath-D silencing in 3T3-F442A murine preadipocytes leads to lipid-depleted cells after adipogenesis induction, and inhibits of the expression of PPARγ, HSL and aP2 adipocyte differentiation markers. Altogether, our findings demonstrate the key role of cath-D in the control of adipogenesis, and suggest that cath-D may be a novel target in obesity.
Liste complète des métadonnées

Littérature citée [25 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00576566
Contributeur : Yves Le Ster <>
Soumis le : lundi 14 mars 2011 - 16:43:33
Dernière modification le : vendredi 29 juin 2018 - 14:48:03
Document(s) archivé(s) le : mercredi 15 juin 2011 - 02:38:06

Identifiants

Citation

Olivier Masson, Christine Prébois, Danielle Derocq, Aline Meulle, Cédric Dray, et al.. Cathepsin-D, a key protease in breast cancer, is up-regulated in obese mouse and human adipose tissue, and controls adipogenesis.: Cathepsin D, adipogenesis and obesity. PLoS ONE, Public Library of Science, 2011, 6 (2), pp.e16452. 〈10.1371/journal.pone.0016452〉. 〈inserm-00576566〉

Partager

Métriques

Consultations de la notice

284

Téléchargements de fichiers

306