Manipulating protein acetylation in breast cancer: a promising approach in combination with hormonal therapies?

Abstract : Estrogens play an essential role in the normal physiology of the breast as well as in mammary tumorigenesis. Their effects are mediated by two nuclear estrogen receptors, ERα and β, which regulate transcription of specific genes by interacting with multiprotein complexes, including histone deacetylases (HDACs). During the past few years, HDACs have raised great interest as therapeutic targets in the field of cancer therapy. In breast cancer, several experimental arguments suggest that HDACs are involved at multiple levels in mammary tumorigenesis: their expression is deregulated in breast tumors; they interfere with ER signaling in intricate ways, restoring hormone sensitivity in models of estrogen resistance, and they clinically represent new potential targets for HDACs inhibitors (HDIs) in combination with hormonal therapies. In this paper, we will describe these different aspects and underline the clinical interest of HDIs in the context of breast cancer resistance to hormone therapies (HTs).
Type de document :
Article dans une revue
Journal of Biomedicine and Biotechnology, Hindawi Publishing Corporation, 2011, 2011, pp.856985. 〈10.1155/2011/856985〉
Liste complète des métadonnées

Littérature citée [140 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00555553
Contributeur : Yves Le Ster <>
Soumis le : jeudi 13 janvier 2011 - 16:55:40
Dernière modification le : lundi 8 janvier 2018 - 17:11:38
Document(s) archivé(s) le : jeudi 14 avril 2011 - 02:53:19

Fichier

856985.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Collections

Citation

Aurélien Linares, Florence Dalenc, Patrick Balaguer, Nathalie Boulle, Vincent Cavailles. Manipulating protein acetylation in breast cancer: a promising approach in combination with hormonal therapies?. Journal of Biomedicine and Biotechnology, Hindawi Publishing Corporation, 2011, 2011, pp.856985. 〈10.1155/2011/856985〉. 〈inserm-00555553〉

Partager

Métriques

Consultations de la notice

233

Téléchargements de fichiers

150