Effects of depressive symptoms and coronary heart disease and their interactive associations on mortality in middle-aged adults: the Whitehall II cohort study.: Depression and mortality by CHD status

Abstract : BACKGROUND: Depression and mortality have been studied separately in patients with coronary heart disease (CHD) and in populations healthy at study inception. This does not allow comparisons across risk-factor groups based on the cross-classification of depression and CHD status. OBJECTIVE: To examine effects of depressive symptoms and CHD and their interactive associations on mortality in middle-aged adults followed over 5.6years. DESIGN AND SETTING: A prospective population-based cohort study of 5936 middle-aged men and women from the British Whitehall II study. We created four risk-factor groups based on the cross-classification of depressive symptoms and CHD status. RESULTS: The age-adjusted and sex-adjusted hazard ratios for death from all causes were 1.67 (p<0.05) for participants with only CHD, 2.10 (p<0.001) for those with only depressive symptoms and 4.99 (p<0.001) for those with both CHD and depressive symptoms when compared to participants without either condition. The two latter risk-factor groups remained at increased risk after adjustments for relevant confounders. The relative excess risk due to the interaction between depressive symptoms and CHD for all-cause mortality was 3.58 (95% CI -0.09 to 7.26), showing some evidence of an additive interaction. A similar pattern was also observed for cardiovascular death. CONCLUSIONS: This study provides evidence that depressive symptoms are associated with an increased risk of all-cause and cardiovascular death and that this risk is particularly marked in depressive participants with co-morbid CHD.
Type de document :
Article dans une revue
Heart, BMJ Publishing Group, 2010, 96 (20), pp.1645-50. 〈10.1136/hrt.2010.198507〉
Liste complète des métadonnées

Littérature citée [22 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00530265
Contributeur : Nadine Kaniewski <>
Soumis le : lundi 21 février 2011 - 08:50:16
Dernière modification le : vendredi 17 février 2017 - 14:30:26
Document(s) archivé(s) le : dimanche 22 mai 2011 - 02:34:02

Fichiers

inserm-00530265_edited.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Hermann Nabi, Martin Shipley, Jussi Vahtera, Martica Hall, Jyrki Korkeila, et al.. Effects of depressive symptoms and coronary heart disease and their interactive associations on mortality in middle-aged adults: the Whitehall II cohort study.: Depression and mortality by CHD status. Heart, BMJ Publishing Group, 2010, 96 (20), pp.1645-50. 〈10.1136/hrt.2010.198507〉. 〈inserm-00530265〉

Partager

Métriques

Consultations de la notice

336

Téléchargements de fichiers

362