C. Roux, A. Saraux, L. Bihan, and E. , Rheumatoid arthritis and spondyloarthropathies: geographical variations in prevalence in France, J Rheumatol, vol.34, pp.117-139, 2007.

E. Leadbetter, I. Rifkin, A. Hohlbaum, B. Beaudette, and M. Shlomchik, Chromatin???IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors, Nature, vol.416, issue.6881, pp.603-610, 2002.
DOI : 10.1038/416603a

P. Matzinger, The Danger Model: A Renewed Sense of Self, Science, vol.296, issue.5566, pp.301-306, 2002.
DOI : 10.1126/science.1071059

S. Ghavami, I. Rashedi, and B. Dattilo, S100A8/A9 at low concentration promotes tumor cell growth via RAGE ligation and MAP kinase-dependent pathway, Journal of Leukocyte Biology, vol.83, issue.6, pp.1484-92, 2008.
DOI : 10.1189/jlb.0607397

A. Broome, D. Ryan, and R. Eckert, S100 Protein Subcellular Localization During Epidermal Differentiation and Psoriasis, Journal of Histochemistry & Cytochemistry, vol.57, issue.7, pp.675-85, 2003.
DOI : 10.1177/002215540305100513

V. Seibert, A. Wiesner, T. Buschmann, and J. Meuer, Surface-enhanced laser desorption ionization time-of-flight mass spectrometry (SELDI TOF-MS) and ProteinChip?? technology in proteomics research, Pathology - Research and Practice, vol.200, issue.2, pp.83-94, 2004.
DOI : 10.1016/j.prp.2004.01.010

S. Vorderwulbecke, G. Kramer, and F. Merz, Low temperature of GroEL/ES overproduction permits growth of Escherichia coli cells lacking trigger factor DnaK, FEBS Lett, vol.579, pp.181-188, 2005.

G. Schellekens, H. Visser, and B. De-jong, The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide, Arthritis & Rheumatism, vol.350, issue.1, pp.155-63, 2000.
DOI : 10.1002/1529-0131(200001)43:1<155::AID-ANR20>3.0.CO;2-3

C. Clarke, J. Buckley, and E. Fung, SELDI-TOF-MS proteomics of breast cancer, Clinical Chemical Laboratory Medicine, vol.43, issue.12, pp.1314-1334, 2005.
DOI : 10.1515/CCLM.2005.225

Z. Zhang, R. Bast, . Jr, and Y. Yu, Three Biomarkers Identified from Serum Proteomic Analysis for the Detection of Early Stage Ovarian Cancer, Cancer Research, vol.64, issue.16, pp.5882-90, 2004.
DOI : 10.1158/0008-5472.CAN-04-0746

J. Albrethsen, R. Bogebo, S. Gammeltoft, J. Olsen, B. Winther et al., Upregulated expression of human neutrophil peptides 1, 2 and 3 (HNP 1-3) in colon cancer serum and tumours: a biomarker study, BMC Cancer, vol.82, issue.11, p.8, 2005.
DOI : 10.1078/0171-9335-00346

C. Trocme, H. Marotte, and A. Baillet, Apolipoprotein A-I and platelet factor 4 are biomarkers for infliximab response in rheumatoid arthritis, Annals of the Rheumatic Diseases, vol.68, issue.8, pp.1328-1361, 2008.
DOI : 10.1136/ard.2008.093153

URL : https://hal.archives-ouvertes.fr/inserm-00382264

D. De-seny, M. Fillet, and M. Meuwis, Discovery of new rheumatoid arthritis biomarkers using the surface-enhanced laser desorption/ionization time-of-flight mass spectrometry ProteinChip approach, Arthritis & Rheumatism, vol.5, issue.12, pp.3801-3813, 2005.
DOI : 10.1002/art.21607

D. De-seny, M. Fillet, and C. Ribbens, Monomeric Calgranulins Measured by SELDI-TOF Mass Spectrometry and Calprotectin Measured by ELISA as Biomarkers in Arthritis, Clinical Chemistry, vol.54, issue.6, pp.1066-75, 2008.
DOI : 10.1373/clinchem.2007.099549

T. Uchida, A. Fukawa, M. Uchida, K. Fujita, and K. Saito, Application of a Novel Protein Biochip Technology for Detection and Identification of Rheumatoid Arthritis Biomarkers in Synovial Fluid, Journal of Proteome Research, vol.1, issue.6, pp.495-504, 2002.
DOI : 10.1021/pr025531w

T. Pap, U. Muller-ladner, R. Gay, and S. Gay, Fibroblast biology Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis, Arthritis Research, vol.2, issue.5, pp.361-368, 2000.
DOI : 10.1186/ar113

F. Arnett, S. Edworthy, and D. Bloch, The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis, Arthritis & Rheumatism, vol.143, issue.3, pp.315-339, 1988.
DOI : 10.1002/art.1780310302

R. Altman, E. Asch, and D. Bloch, Development of criteria for the classification and reporting of osteoarthritis: Classification of osteoarthritis of the knee, Arthritis & Rheumatism, vol.1, issue.8, pp.1039-1088, 1986.
DOI : 10.1002/art.1780290816

S. Van-der-linden, H. Valkenburg, and A. Cats, Evaluation of Diagnostic Criteria for Ankylosing Spondylitis, Arthritis & Rheumatism, vol.2, issue.4, pp.361-369, 1984.
DOI : 10.1002/art.1780270401

R. Petty, T. Southwood, and P. Manners, International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, J Rheumatol, vol.31, pp.390-392, 2001.

E. Tan, A. Cohen, and J. Fries, The 1982 revised criteria for the classification of systemic lupus erythematosus, Arthritis & Rheumatism, vol.31, issue.11, pp.1271-1278, 1982.
DOI : 10.1002/art.1780251101

H. Schagger and -. Tricine, Tricine???SDS-PAGE, Nature Protocols, vol.39, issue.1, pp.16-22, 2006.
DOI : 10.1038/nprot.2006.4

S. Berthier, M. Paclet, and S. Lerouge, Changing the Conformation State of Cytochrome b558 Initiates NADPH Oxidase Activation: MRP8/MRP14 REGULATION, Journal of Biological Chemistry, vol.278, issue.28, pp.25499-508, 2003.
DOI : 10.1074/jbc.M209755200

URL : https://hal.archives-ouvertes.fr/hal-00313172

M. Paclet, S. Berthier, L. Kuhn, J. Garin, and F. Morel, Regulation of phagocyte NADPH oxidase activity: identification of two cytochrome b558 activation states, The FASEB Journal, vol.21, issue.4, pp.1244-55, 2007.
DOI : 10.1096/fj.06-6852com

URL : https://hal.archives-ouvertes.fr/hal-00400467

M. Bokarewa, J. T. Tarkowski, and A. , Intraarticular release and accumulation of defensins and bactericidal/ permeability-increasing protein in patients with rheumatoid arthritis, J Rheumatol, vol.30, pp.1719-1743, 2003.

I. Buhimschi, C. Buhimschi, and C. Weiner, Proteomic but Not Enzyme-Linked Immunosorbent Assay Technology Detects Amniotic Fluid Monomeric Calgranulins from Their Complexed Calprotectin Form, Clinical and Vaccine Immunology, vol.12, issue.7, pp.837-881, 2005.
DOI : 10.1128/CDLI.12.7.837-844.2005

B. Mcmorran, S. Patat, and J. Carlin, Novel Neutrophil-Derived Proteins in Bronchoalveolar Lavage Fluid Indicate an Exaggerated Inflammatory Response in Pediatric Cystic Fibrosis Patients, Clinical Chemistry, vol.53, issue.10, pp.1782-91, 2007.
DOI : 10.1373/clinchem.2007.087650

G. Lominadze, M. Rane, M. Merchant, J. Cai, R. Ward et al., Myeloid-Related Protein-14 Is a p38 MAPK Substrate in Human Neutrophils, The Journal of Immunology, vol.174, issue.11, pp.7257-67, 2005.
DOI : 10.4049/jimmunol.174.11.7257

A. Sinz, M. Bantscheff, and S. Mikkat, Mass spectrometric proteome analyses of synovial fluids and plasmas from patients suffering from rheumatoid arthritis and comparison to reactive arthritis or osteoarthritis, ELECTROPHORESIS, vol.23, issue.19, pp.3445-56, 2002.
DOI : 10.1002/1522-2683(200210)23:19<3445::AID-ELPS3445>3.0.CO;2-J

S. Drynda, B. Ringel, and M. Kekow, Proteome analysis reveals disease-associated marker proteins to differentiate RA patients from other inflammatory joint diseases with the potential to monitor anti-TNF?? therapy, Pathology - Research and Practice, vol.200, issue.2, pp.165-71, 2004.
DOI : 10.1016/j.prp.2004.02.011

H. Liao, J. Wu, and E. Kuhn, Use of mass spectrometry to identify protein biomarkers of disease severity in the synovial fluid and serum of patients with rheumatoid arthritis, Arthritis & Rheumatism, vol.274, issue.12, pp.3792-803, 2004.
DOI : 10.1002/art.20720

K. Tilleman, K. Van-beneden, and A. Dhondt, Chronically inflamed synovium from spondyloarthropathy and rheumatoid arthritis investigated by protein expression profiling followed by tandem mass spectrometry, PROTEOMICS, vol.363, issue.8, pp.2247-57, 2005.
DOI : 10.1002/pmic.200401109

N. Wulffraat, P. Haas, and M. Frosch, Myeloid related protein 8 and 14 secretion reflects phagocyte activation and correlates with disease activity in juvenile idiopathic arthritis treated with autologous stem cell transplantation, Annals of the Rheumatic Diseases, vol.62, issue.3, pp.236-277, 2003.
DOI : 10.1136/ard.62.3.236

S. Odegard and M. Fagerhol, Calprotectin (a major leucocyte protein) is strongly and independently correlated with joint inflammation and damage in rheumatoid arthritis, Ann Rheum Dis, vol.66, pp.1093-1100, 2007.

D. Foell, D. Kane, and B. Bresnihan, Expression of the pro-inflammatory protein S100A12 (EN-RAGE) in rheumatoid and psoriatic arthritis, Rheumatology, vol.42, issue.11, pp.1383-1392, 2003.
DOI : 10.1093/rheumatology/keg385

D. Foell, H. Wittkowski, and I. Hammerschmidt, Monitoring neutrophil activation in juvenile rheumatoid arthritis by S100A12 serum concentrations, Arthritis & Rheumatism, vol.24, issue.4, pp.1286-95, 2004.
DOI : 10.1002/art.20125

F. Paulsen, T. Pufe, and L. Conradi, Antimicrobial peptides are expressed and produced in healthy and inflamed human synovial membranes, The Journal of Pathology, vol.15, issue.3, pp.369-77, 2002.
DOI : 10.1002/path.1224

P. Van-lent, L. Grevers, and A. Blom, Myeloid-related proteins S100A8/S100A9 regulate joint inflammation and cartilage destruction during antigen-induced arthritis, Annals of the Rheumatic Diseases, vol.67, issue.12, pp.1750-1758, 2008.
DOI : 10.1136/ard.2007.077800

P. Youssef, J. Roth, and M. Frosch, Expression of myeloid related proteins (MRP) 8 and 14 and the MRP8/14 heterodimer in rheumatoid arthritis synovial membrane, J Rheumatol, vol.26, pp.2523-2531, 1999.

C. Dale, P. Rde, L. Paccola, and C. , Effect of the C-terminus of murine S100A9 protein on experimental nociception, Peptides, vol.27, issue.11, pp.2794-802, 2006.
DOI : 10.1016/j.peptides.2006.07.002

K. Mitchell, H. Yang, and P. Tessier, Localization of S100A8 and S100A9 expressing neutrophils to spinal cord during peripheral tissue inflammation, Pain, vol.134, issue.1, pp.216-247, 2008.
DOI : 10.1016/j.pain.2007.10.024

M. Steenvoorden, R. Toes, H. Ronday, T. Huizinga, and J. Degroot, RAGE activation induces invasiveness of RA fibroblast-like synoviocytes in vitro, Clin Exp Rheumatol, vol.25, pp.740-742, 2007.

T. Tolboom, E. Pieterman, and W. Van-der-laan, Invasive properties of fibroblast-like synoviocytes: correlation with growth characteristics and expression of MMP-1, MMP-3, and MMP-10, Annals of the Rheumatic Diseases, vol.61, issue.11, pp.975-80, 2002.
DOI : 10.1136/ard.61.11.975

C. Ryckman, S. Mccoll, and K. Vandal, Role of S100A8 and S100A9 in neutrophil recruitment in response to monosodium urate monohydrate crystals in the air-pouch model of acute gouty arthritis, Arthritis & Rheumatism, vol.51, issue.8, pp.2310-2330, 2003.
DOI : 10.1002/art.11079

M. Mccormick, F. Rahimi, and Y. Bobryshev, S100A8 and S100A9 in Human Arterial Wall: IMPLICATIONS FOR ATHEROGENESIS, Journal of Biological Chemistry, vol.280, issue.50, pp.41521-41530, 2005.
DOI : 10.1074/jbc.M509442200

L. Altwegg, M. Neidhart, and M. Hersberger, Myeloid-related protein 8/14 complex is released by monocytes and granulocytes at the site of coronary occlusion: a novel, early, and sensitive marker of acute coronary syndromes, European Heart Journal, vol.28, issue.8, pp.941-949, 2007.
DOI : 10.1093/eurheartj/ehm078