J. D. and L. A. Buck-cr, Expression and structure of the human NGF receptor, Cell, vol.47, pp.545-554, 1986.

M. Aw, F. Bm, and . Headon-dj, Mutations in the human homologue of mouse dl cause autosomal recessive and dominant hypohidrotic ectodermal dysplasia FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptorinduced apoptosis, Nat Genet J Biol Chem, vol.22, issue.271, pp.366-3694961, 1996.

C. Muzio-m, . Am, and . Kischkel-fc, FLICE, A Novel FADD-Homologous ICE/CED-3???like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex, Cell, vol.85, issue.6, pp.817-827, 1996.
DOI : 10.1016/S0092-8674(00)81266-0

B. Mp, G. Tm, G. Yv, and W. D. , Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1-and TNF receptor-induced cell death, Cell, vol.85, pp.803-815, 1996.

S. Sm, A. M. , F. , L. G. , and A. Es, Molecular ordering of the Fas-apoptotic pathway: the Fas

K. Fc and H. S. Behrmann-i, Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor, Embo J, vol.14, pp.5579-5588, 1995.

W. Ch and V. C. , The death domain superfamily: a tale of two interfaces?, Trends Biochem Sci, vol.26, pp.475-481, 2001.

M. M. , S. Br, S. Hr, S. Gs, and D. Vm, An induced proximity model for caspase-8 activation, J Biol Chem, vol.273, pp.2926-2930, 1998.

T. Cb, Apoptosis in the pathogenesis and treatment of disease, Science, vol.267, pp.1456-1462, 1995.

S. Hb, G. Halpin-dr, and . Dv, Casper is a FADD-and caspase-related inducer of apoptosis, Immunity, vol.6, pp.751-763, 1997.

S. Sm, A. M. , and O. S. , FLAME-1, a novel FADDlike anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis, J Biol Chem, vol.272, pp.18542-18545, 1997.

G. Yv, K. Av, and A. E. , CASH, a novel caspase homologue with death effector domains, J Biol Chem, vol.272, pp.19641-19644, 1997.

H. S. , V. C. , N. J. , G. R. , and D. Vm, I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1-and CD-95-induced apoptosis, J Biol Chem, vol.272, pp.17255-17257, 1997.

R. Dm, . Vaillancourt-jp, and . Hadano-s, Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex, Cell Death Differ, vol.5, pp.271-288, 1998.

D. J. Birge-rb and M. , Fas engagement induces neurite growth through ERK activation and p35 upregulation, Nat Cell Biol, vol.5, pp.118-125, 2003.

V. Ee, S. M. , and L. V. , Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally, Immunity, vol.9, pp.267-276, 1998.

F. S. , M. E. , and D. Km, Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domainlike interleukin 1-converting enzyme inhibitory protein expression, Cancer Res, vol.60, pp.3947-3956, 2000.

L. S. and M. O. Hammann, Chemotherapy enhances TNF-related apoptosis-inducing Ligand DISC assembly in HT29 human colon cancer cells Doxorubicin Pretreatment Sensitizes Prostate Cancer Cell Lines to TRAIL Induced Apoptosis Which Correlates with the Loss of c-FLIP Expression, Oncogene Cancer Biol Ther, vol.22, issue.1, pp.1807-1816520, 2002.

K. H. and Y. H. Shiiki-k, Cisplatin (CDDP) sensitizes human osteosarcoma cell to Fas/CD95-mediated apoptosis by down-regulating FLIP-L expression, Int J Cancer, vol.88, pp.986-991, 2000.

F. T. and F. T. Uno-f, Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells, Oncogene, vol.20, issue.10, pp.5225-5231, 2001.

K. Y. , S. N. , S. M. , and R. Jc, An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis, J Biol Chem, vol.277, pp.22320-22329, 2002.

S. Mk, S. Yk, S. Oa, and Z. Y. , Interferon-beta therapy downregulates the anti-apoptosis protein FLIP in T cells from patients with multiple sclerosis, J Neuroimmunol, vol.120, pp.199-207, 2001.

G. C. , S. E. De-smaele-e, F. G. , and V. P. , c-FLIP efficiently rescues TRAF-2-/-cells from TNF-induced apoptosis, Cell Death Differ, vol.9, pp.138-144, 2002.

H. V. and P. M. Heiskanen-km, Erythroid Differentiation Sensitizes K562 Leukemia Cells to TRAIL-Induced Apoptosis by Downregulation of c-FLIP, Mol Cell Biol, vol.23, pp.1278-1291, 2003.

S. T. , M. T. , O. Be, and W. K. , Phosphatidylinositol 3- kinase/Akt signaling controls endothelial cell sensitivity to Fas-mediated apoptosis via regulation of FLICE-inhibitory protein (FLIP), Circ Res, vol.89, pp.13-19, 2001.

P. Dj, M. T. , S. T. , W. K. , and M. Jw, Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells, J Biol Chem, vol.276, pp.6893-6896, 2001.

N. Sy, A. Aa, and L. Yj, Low glucose-enhanced TRAIL cytotoxicity is mediated through the ceramide-Akt-FLIP pathway, Oncogene, vol.21, pp.337-346, 2002.

Y. Jh, H. Sc, H. Sh, and L. Mz, Mitogen-activated protein kinase kinase antagonized fas-associated death domain protein-mediated apoptosis by induced FLICE-inhibitory protein expression, J Exp Med, vol.188, issue.10, pp.1795-1802, 1998.

W. W. , P. Cz, M. Y. , and P. Mj, Notch3 signaling in vascular smooth muscle cells induces c-FLIP expression via ERK/MAPK activation. Resistance to Fas ligand-induced apoptosis, J Biol Chem, vol.277, pp.21723-21729, 2002.

C. Ij, D. C. , K. Sb, Y. Bf, X. C. et al., Stem Cell Factor increases the expression of FLIP which inhibits IFN{gamma}-induced apoptosis in human erythroid progenitor cells 10:10. 76 Calcium/calmodulindependent protein kinase II regulation of c-FLIP expression and phosphorylation in modulation of Fas-mediated signaling in malignant glioma cells, Blood J Biol Chem, vol.278, pp.7043-7050, 2002.

X. Cw, Y. X. , L. Y. , R. Sa, and T. Bk, Resistance of human ovarian cancer cells to tumor necrosis factor alpha is a consequence of nuclear factor kappaB-mediated induction of Fas-associated death domain-like interleukin-1beta-converting enzyme-like inhibitory protein, Endocrinology, vol.144, pp.623-630, 2003.

H. H. , Y. Jh, and G. A. , Bile acids stimulate cFLIP phosphorylation enhancing TRAIL-mediated apoptosis, J Biol Chem, vol.278, pp.454-461, 2003.

S. Kh, L. Th, and D. Ws, Adhesion-mediated intracellular redistribution of c-Fas-associated death domain-like IL-1-converting enzyme-like inhibitory protein-long confers resistance to CD95-induced apoptosis in hematopoietic cancer cell lines, J Immunol, vol.168, pp.2544-2553, 2002.

R. , L. Deist-f, and F. A. , Autoimmune lymphoproliferative syndromes: genetic defects of apoptosis pathways, Cell Death Differ, vol.10, pp.124-133, 2003.

C. Hj, Z. L. , and A. M. , Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency, Nature, vol.419, pp.395-399, 2002.

A. , G. Ts, L. Dh, and P. Cv, First indication of caspase-8 mutations leading to human immunodeficiency Cell cycle-dependent regulation of FLIP levels and susceptibility to Fas-mediated apoptosis, J Immunol, vol.83, issue.162, pp.5205-5211, 1999.

R. Y. Van-parijs-l, A. Ak, and B. D. , Autoimmunity as a Consequence of Retrovirus-Mediated Expression of C-FLIP in Lymphocytes, Immunity, vol.30, issue.4, pp.763-770, 1999.
DOI : 10.1016/j.immuni.2009.04.003

D. Felice, F. , F. St, T. Cm, F. Friedman-je et al., Beta-amyloid production, aggregation, and clearance as targets for therapy in Alzheimer's disease WELLINGTON CL, HAYDEN MR: Caspases and neurodegeneration: on the cutting edge of new therapeutic approaches Mechanisms of p75-mediated death of hippocampal neurons. Role of caspases, Cellular and Molecular Neurobiology, vol.22, issue.5/6, pp.545-5631, 2000.
DOI : 10.1023/A:1021832302524

Y. M. and Z. S. Fine-re, Amyloid beta binds trimers as well as monomers of the 75-kDa neurotrophin receptor and activates receptor signaling, J Biol Chem, vol.277, pp.7720-7725, 2002.

W. W. , N. Dd, W. X. , and K. Jw, Abeta 17-42 in Alzheimer's disease activates JNK and caspase-8 leading to neuronal apoptosis, Brain, vol.125, pp.2036-2043, 2002.

L. Bonfoco-e and K. Y. , Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death, Mol Cell Biol, vol.19, pp.751-763, 1999.

H. T. , C. Fx, and K. T. , Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury, J Neurosci, vol.18, pp.5124-5135, 1998.

S. Q. , M. H. , and C. Pm, The human herpes virus 8-encoded viral FLICE inhibitory protein protects against growth factor withdrawal-induced apoptosis via NF-kappa B activation, Blood, vol.101, pp.1956-1961, 2003.

E. E. , G. T. , Y. Bc, C. N. , and L. G. , Alteration of caspases and apoptosis-related proteins in brains of patients with Alzheimer's disease, Biochem Biophys Res Commun, vol.281, pp.84-93, 2001.

Z. M. , C. Dh, and A. Aj, The induction of the TNFalpha death domain signaling pathway in Alzheimer's disease brain, Neurochem Res, vol.28, pp.307-318, 2003.

M. Vu-t, . Lw, M. F. Ellison-gw, and B. Jm, T-cell responses to oligodendrocyte-specific protein in multiple sclerosis, Journal of Neuroscience Research, vol.105, issue.3, pp.506-509, 2001.
DOI : 10.1002/jnr.1241

H. Cg and G. J. Brehm-u, The fine specificity of the myelin oligodendrocyte glycoprotein autoantibody response in patients with multiple sclerosis and normal healthy controls, J Neuroimmunol, vol.114, issue.10, pp.220-225, 2001.

B. Jm, L. Rl, . Seitz-rs, M. Ellison-gw, and . Lw, A humoral response to oligodendrocyte-specific protein in MS: a potential molecular mimic, Neurology, vol.53, pp.154-161, 1999.

S. Ka, R. Jh, and C. Ah, Role of Fas--FasL interactions in the pathogenesis and regulation of autoimmune demyelinating disease, J Neuroimmunol, vol.100, pp.42-52, 1999.

D. Sd and B. B. Balasingam-v, Multiple sclerosis: Fas signaling in oligodendrocyte cell death, J Exp Med, vol.184, pp.2361-2370, 1996.

I. A. , K. Cs, and S. T. , Detection of the soluble form of the Fas molecule in patients with multiple sclerosis and human T-lymphotropic virus type I-associated myelopathy, J Neuroimmunol, vol.75, pp.141-146, 1997.

Z. Md, L. M. Solano-f, F. Mj, and I. G. , Association of a CA repeat polymorphism upstream of the Fas ligand gene with multiple sclerosis, J Neuroimmunol, vol.116, pp.238-241, 2001.

D. M. , A. Kb, and A. , Expression of the Long Form of Human FLIP by Retroviral Gene Transfer of Hemopoietic Stem Cells Exacerbates Experimental Autoimmune Encephalomyelitis, J Immunol, vol.170, pp.2064-2073, 2003.

S. Yk, S. Oa, and S. Mk, Overexpression of the apoptosis inhibitor FLIP in T cells correlates with disease activity in multiple sclerosis, J Neuroimmunol, vol.113, issue.10, pp.268-274, 2001.

N. T. Sasaki-h and T. M. , Inhibitory effect of glucocorticoid for osteoblast apoptosis induced by activated peripheral blood mononuclear cells, Endocrinology, vol.139, pp.2032-2040, 1998.

H. Tt, H. T. , and A. H. , Novel mechanisms of selective apoptosis in synovial T cells of patients with rheumatoid arthritis, J Rheumatol, vol.23, pp.1332-1337, 1996.

S. T. , H. Tt, A. H. , H. T. , and N. K. , T cell receptor of Fas-sensitive T cells in rheumatoid synovium, J Immunol, vol.158, pp.1965-1970, 1997.

L. Se, Z. Sj, M. Ka, P. J. , and C. Yh, Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL, Nat Immunol, vol.4, pp.255-260, 2003.

F. M. and M. Rn, Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?, Annu Rev Immunol, vol.19, pp.163-196, 2001.

I. Mr, T. S. , and I. J. , Rheumatic diseases in an MRL strain of mice with a deficit in the functional Fas ligand, Arthritis Rheum, vol.40, pp.1054-1063, 1997.

P. H. , P. Lj, and . Liu-h, Rheumatoid arthritis synovial macrophages express the Fas-associated death domain-like interleukin-1beta- converting enzyme-inhibitory protein and are refractory to Fas-mediated apoptosis, Arthritis Rheum, vol.44, pp.21-30, 2001.

S. Ay, T. A. Green-ea, F. Ra, and C. Av, Contribution of Fas to diabetes development, Proc Natl Acad Sci U S A, vol.100, pp.628-632, 2003.

J. Am, P. V. , and M. N. , Suppression of Fas-FasLinduced endothelial cell apoptosis prevents diabetic blood-retinal barrier breakdown in a model of streptozotocin-induced diabetes, Faseb J, vol.17, pp.76-78, 2003.

H. Fm, S. Dr, and . Davies-gj, Tumour necrosis factor and inducible nitric oxide synthase in dilated cardiomyopathy, Lancet, vol.347, issue.10, pp.1151-1155, 1996.

K. T. Mctiernan-cf and . Frye-cs, Dilated cardiomyopathy in transgenic mice with cardiac-specific overexpression of tumor necrosis factoralpha, Circ Res, vol.81, pp.627-635, 1997.

S. C. , A. Ca, and P. Jg, Alterations in apoptotic signaling in human idiopathic cardiomyopathic hearts in failure, Am J Physiol Heart Circ Physiol, vol.284, pp.268-276, 2003.

I. T. , M. Ce, and R. H. , Cellular FLIP is expressed in cardiomyocytes and down-regulated in TUNEL-positive grafted cardiac tissues, Cardiovasc Res, vol.48, pp.101-110, 2000.

S. Db, V. G. , and W. S. , Expression of Fas ligand in arteries of hypercholesterolemic rabbits accelerates atherosclerotic lesion formation, Arterioscler Thromb Vasc Biol, vol.20, pp.298-308, 2000.

I. T. and M. J. Ho-q, Expression of cellular FLICEinhibitory protein in human coronary arteries and in a rat vascular injury model, Am J Pathol, vol.156, pp.125-137, 2000.

Y. Wc, H. R. Woo-m, and M. Tw, Gene targeting in the analysis of mammalian apoptosis and TNF receptor superfamily signaling, Immunol Rev, vol.169, pp.283-302, 1999.

Y. Wc, P. Jl, and M. Me, FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis, Science, vol.279, pp.1954-1958, 1998.

K. Kw and V. B. , Lessons from hereditary colorectal cancer, Cell, vol.87, issue.10, pp.159-170, 1996.

L. C. , K. Kw, and V. B. , Genetic instabilities in human cancers, Nature, vol.396, pp.643-649, 1998.

T. K. and H. Y. Smyth-mj, Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells, Nat Med, vol.7, pp.94-100, 2001.

T. K. , S. Mj, and C. E. , Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development, J Exp Med, vol.195, pp.161-169, 2002.

T. K. , S. Mj, and C. E. , Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-gammadependent suppression of subcutaneous tumor growth, Cell Immunol, vol.214, pp.194-200, 2001.

S. Mj, C. E. , and T. K. , Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis, J Exp Med, vol.193, pp.661-670, 2001.

K. Sk and H. L. Xie-d, Preclinical studies to predict the disposition of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand in humans: characterization of in vivo efficacy, pharmacokinetics, and safety, J Pharmacol Exp Ther, vol.299, pp.31-38, 2001.

F. Le and T. J. , Defective death receptor signaling as a cause of tumor immune escape, Semin Cancer Biol, vol.12, pp.51-55, 2002.

F. Le and T. J. , Inhibition of death receptor signaling by FLICEinhibitory protein as a mechanism for immune escape of tumors, J Exp Med, vol.190, pp.891-894, 1999.

I. M. and P. J. Bonnefoix-t, Resistance to CD95-mediated apoptosis through constitutive c-FLIP expression in a non-Hodgkin's lymphoma B cell line, Leukemia, vol.14, pp.2149-2158, 2000.

T. Cg and S. Mf, Modulation of caspase-8 and FLICE-inhibitory protein expression as a potential mechanism of Epstein-Barr virus tumorigenesis in Burkitt's lymphoma, Blood, vol.94, pp.1727-1737, 1999.

T. Rk and K. A. Wickenhauser-c, Constitutive expression of c-FLIP in Hodgkin and Reed-Sternberg cells, Am J Pathol, vol.160, pp.1521-1528, 2002.

M. Jp, J. J. De, M. Van-hall-t, and O. R. Cj, Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein, J Exp Med, vol.190, pp.1033-1038, 1999.

R. Bk, L. Mg, C. Sg, K. Yw, and P. Jh, Increased expression of cFLIP(L) in colonic adenocarcinoma, J Pathol, vol.194, pp.15-19, 2001.

G. Ts, C. Wa, J. Gc, L. Dh, and K. Mz, Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells, J Immunol, vol.161, pp.2833-2840, 1998.

B. Rr, H. B. , and V. , Selective expression of FLIP in malignant melanocytic skin lesions, J Invest Dermatol, vol.117, pp.360-364, 2001.

R. M. Bektas-m and W. T. , Resistance to CD95/Fas-induced and ceramide-mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome c release, FEBS Lett, vol.473, pp.27-32, 2000.

Z. Xd and F. A. Myers-k, Relation of TNF-related apoptosisinducing ligand (TRAIL) receptor and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of melanoma, Cancer Res, vol.59, pp.2747-2753, 1999.

C. S. and A. Jm, The Bcl2 family: regulators of the cellular life-or-death switch, Nat Rev Cancer, vol.2, pp.647-656, 2002.

S. V. Wallin-rp, L. Hg, and G. A. , A central role for death receptor-mediated apoptosis in the rejection of tumors by NK cells, J Immunol, vol.167, pp.2068-2073, 2001.

T. Ma, C. Pm, and K. J. , Inhibition of the death receptor pathway by cFLIP confers partial engraftment of MHC class I-deficient stem cells and reduces tumor clearance in perforin-deficient mice, J Immunol, vol.167, pp.4230-4237, 2001.

S. Mj, T. K. , and H. Y. , Nature's TRAIL-On a Path to Cancer Immunotherapy, Immunity, vol.18, pp.1-6, 2003.

F. S. , K. Mu, and M. E. , Sensitization for death receptor-or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer, Oncogene, vol.20, pp.5865-5877, 2001.

K. Sh and E. Wc, Induction of apoptosis by cancer chemotherapy, Exp Cell Res, vol.256, pp.42-49, 2000.

L. Th, G. Mc, and D. Ws, Selection for drug resistance results in resistance to Fas-mediated apoptosis, Blood, vol.89, issue.10, pp.1854-1861, 1997.

E. A. and B. S. Atkins-gj, Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to Apo2L/TRAIL-induced apoptosis, Int J Cancer, vol.99, pp.491-504, 2002.

H. A. , W. Qd, S. Sa, and E. Bm, Sensitization of human colon cancer cells to TRAIL-mediated apoptosis, J Gastrointest Surg, vol.5, pp.56-65, 2001.

K. Mm, E. Sa, N. Mm, R. Ek, and L. S. , Chemotherapy augments TRAIL-induced apoptosis in breast cell lines, Cancer Res, vol.59, pp.734-741, 1999.

L. S. and H. A. Wotawa, Anticancer agents sensitize tumor cells to tumor necrosis factor-related apoptosis-inducing ligand-mediated caspase-8 activation and apoptosis, Cancer Res, vol.61, pp.1645-1651, 2001.

N. T. , S. K. , and H. Bl, Effects of tumor necrosis factor-related apoptosis-inducing ligand alone and in combination with chemotherapeutic agents on patients' colon tumors grown in SCID mice, Cancer Res, vol.62, pp.5800-5806, 2002.

F. S. Brunner-t, G. M. , and U. A. Schmid-ra, Enhancement of Apo2L/TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-induced apoptosis in non-small cell lung cancer cell lines by chemotherapeutic agents without correlation to the expression level of cellular protease caspase-8 inhibitory protein, J Thorac Cardiovasc Surg, vol.123, pp.168-174, 2002.

L. W. , B. E. , and C. Jy, Tumor necrosis factor-related apoptosisinducing ligand and chemotherapy cooperate to induce apoptosis in mesothelioma cell lines, Am J Respir Cell Mol Biol, vol.25, pp.111-118, 2001.

N. M. and P. G. Weddle-jj, Increased death receptor 5 expression by chemotherapeutic agents in human gliomas causes synergistic cytotoxicity with tumor necrosis factor-related apoptosis-inducing ligand in vitro and in vivo, Cancer Res, vol.60, pp.847-853, 2000.

M. A. Mcdonnell-tj and M. Re, Chemotherapeutic agents enhance TRAIL-induced apoptosis in prostate cancer cells, Cancer Chemother Pharmacol, vol.50, issue.10, pp.46-52, 2002.

C. M. , E. Sa, N. Mm, and L. S. , Synergistic induction of apoptosis by the combination of trail and chemotherapy in chemoresistant ovarian cancer cells, Gynecol Oncol, vol.81, pp.380-390, 2001.

M. Ae, P. Dh, and . Hodgkin-ea, Induction of apoptosis by chemotherapeutic drugs: the role of FADD in activation of caspase-8 and synergy with death receptor ligands in ovarian carcinoma cells, Cell Death Differ, vol.9, pp.287-300, 2002.

A. A. Pai-rc and . Fong-s, Safety and antitumor activity of recombinant soluble Apo2 ligand, J Clin Invest, vol.104, pp.155-162, 1999.

H. Ml, S. S. , and K. Y. , Downregulation of c-FLIP Sensitizes DU145 Prostate Cancer Cells to Fas-Mediated Apoptosis, Cancer Biol Ther, vol.1, pp.401-406, 2002.

P. V. , M. Cs, and K. V. , Regulation of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in thyroid carcinoma cells, Am J Pathol, vol.161, issue.10, pp.643-654, 2002.

S. D. , H. P. , P. K. , V. Hp, and W. H. , Selective Inhibition of FLICE-like Inhibitory Protein Expression With Small Interfering RNA Oligonucleotides Is Sufficient to Sensitize Tumor Cells for TRAIL-Induced Apoptosis, Mol Med, vol.8, pp.725-732, 2002.

M. O. , S. E. , H. A. , M. F. , and D. Mt, Sensitization of cancer cells treated with cytotoxic drugs to fasmediated cytotoxicity, J Natl Cancer Inst, vol.89, pp.783-789, 1997.

C. D. and S. I. Krueger-a, Induction of apoptosis in 9- nitrocamptothecin-treated DU145 human prostate carcinoma cells correlates with de novo synthesis of CD95 and CD95 ligand and down-regulation of c- FLIP(short), Cancer Res, vol.61, pp.7148-7154, 2001.

M. H. , E. M. , G. Af, and C. Pm, Role of MRIT/cFLIP in protection against chemotherapy-induced apoptosis, Cancer Biol Ther, vol.6, pp.652-660, 2002.

M. O. , S. E. , H. A. , and D. Mt, Fas ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs, J Biol Chem, vol.274, pp.7987-7992, 1999.

E. A. , G. Ma, and Z. Tj, Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression, Cancer Res, vol.61, pp.1314-1319, 2001.

E. Ih and S. A. Stroh-c, Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis, Oncogene, vol.19, pp.4563-4573, 2000.

K. Pk, M. R. , and S. Dw, The role of caspase-8 in resistance to cancer chemotherapy, Drug Resist Updat, vol.4, pp.293-296, 2001.

H. , B. Jl, and . Bourloud-kb, Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates 10, 2010.

Z. Tj, S. Df, and S. Ln, Loss of caspase-8 mRNA expression is common in childhood primitive neuroectodermal brain tumour/medulloblastoma, Eur J Cancer, vol.38, pp.83-91, 2002.

H. K. and T. S. Shivapurkar-n, Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines, Cancer Res, vol.62, pp.5897-5901, 2002.

S. N. and T. S. Eby-mt, Differential inactivation of caspase-8 in lung cancers, Cancer Biol Ther, vol.1, pp.65-69, 2002.