V. Fodale, L. Santamaria, D. Schifilliti, and P. Mandal, Anaesthetics and postoperative cognitive dysfunction: a pathological mechanism mimicking Alzheimer???s disease, Anaesthesia, vol.26, issue.4, pp.388-395, 2010.
DOI : 10.1111/j.1365-2044.2010.06244.x

L. Evered, B. Silbert, D. Scott, P. Maruff, K. Laughton et al., Plasma Amyloid ??42 and Amyloid ??40 Levels Are Associated With Early Cognitive Dysfunction After Cardiac Surgery, The Annals of Thoracic Surgery, vol.88, issue.5, pp.1426-1432, 2009.
DOI : 10.1016/j.athoracsur.2009.07.003

X. Run, Z. Liang, L. Zhang, K. Iqbal, I. Grundke-iqbal et al., Anesthesia Induces Phosphorylation of Tau, Journal of Alzheimer's Disease, vol.16, issue.3, pp.619-626, 2009.
DOI : 10.3233/JAD-2009-1003

S. Newman, J. Stygall, S. Hirani, S. Shaefi, and M. Maze, Postoperative Cognitive Dysfunction after Noncardiac Surgery, Anesthesiology, vol.106, issue.3, pp.572-590, 2007.
DOI : 10.1097/00000542-200703000-00023

C. Hanning, Postoperative cognitive dysfunction, British Journal of Anaesthesia, vol.95, issue.1, pp.82-87, 2005.
DOI : 10.1093/bja/aei062

C. Wu, W. Hsu, J. Richman, S. Raja, P. Williams-russo et al., Postoperative cognitive function as an outcome of regional anesthesia and analgesia Cognitive effects after epidural vs general anesthesia in older adults: a randomized trial, Reg Anesth Pain Med. JAMA, vol.297, issue.274, pp.257-268, 1995.

L. Rasmussen, Postoperative cognitive dysfunction: Incidence and prevention, Best Practice & Research Clinical Anaesthesiology, vol.20, issue.2, pp.315-330, 2006.
DOI : 10.1016/j.bpa.2005.10.011

L. Rasmussen, T. Johnson, H. Kuipers, D. Kristensen, V. Siersma et al., Does anaesthesia cause postoperative cognitive dysfunction? A randomised study of regional versus general anaesthesia in 438 elderly patients, Acta Anaesthesiologica Scandinavica, vol.66, issue.3, pp.260-266, 2003.
DOI : 10.1136/bmj.321.7275.1493

C. Hirsch, When your patient needs surgery: How planning can avoid complications, Geriatrics, vol.50, pp.39-44, 1995.

S. Parikh and F. Chung, Postoperative delirium in elderly, Anesth. Analg, vol.80, pp.1223-1232, 1995.

M. Goldstein, B. Young, B. Fogel, and R. Benedict, Occurrence and Predictors of Short-Term Mental and Functional Changes in Older Adults Undergoing Elective Surgery Under General Anesthesia, American Journal of Geriatric Psychiatry, vol.6, issue.1, pp.42-52, 1998.
DOI : 10.1097/00019442-199800610-00006

E. Corder, A. Saunders, W. Strittmatter, D. Schmechel, P. Gaskell et al., Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families, Science, vol.261, issue.5123, pp.921-923, 1993.
DOI : 10.1126/science.8346443

J. Poirier, J. Davignon, D. Bouthillier, S. Kogan, P. Bertrand et al., Apolipoprotein E polymorphism and Alzheimer's disease, The Lancet, vol.342, issue.8873, pp.697-699, 1993.
DOI : 10.1016/0140-6736(93)91705-Q

W. Strittmatter, A. Saunders, D. Schmechel, M. Pericak-vance, J. Enghild et al., Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease., Proceedings of the National Academy of Sciences, vol.90, issue.5, 1977.
DOI : 10.1073/pnas.90.5.1977

J. Nicoll, G. Roberts, and D. Graham, Apolipoprotein E ??4 allele is associated with deposition of amyloid ??-protein following head injury, Nature Medicine, vol.3, issue.2, pp.135-137, 1995.
DOI : 10.1016/0140-6736(91)92823-K

G. Teasdale, J. Nicoll, G. Murray, and M. Fiddes, Association of apolipoprotein E polymorphism with outcome after head injury, The Lancet, vol.350, issue.9084, pp.1069-1071, 1997.
DOI : 10.1016/S0140-6736(97)04318-3

K. Horsburgh, M. Mccarron, F. White, and J. Nicoll, The role of apolipoprotein E in Alzheimer???s disease, acute brain injury and cerebrovascular disease: evidence of common mechanisms and utility of animal models, Neurobiology of Aging, vol.21, issue.2, pp.245-255, 2000.
DOI : 10.1016/S0197-4580(00)00097-X

B. Tardiff, M. Newman, A. Saunders, W. Strittmatter, J. Blumenthal et al., Preliminary Report of a Genetic Basis for Cognitive Decline After Cardiac Operations 11The members of the Neurologic Outcome Research Group of the Duke Heart Center are listed in Appendix A., The Annals of Thoracic Surgery, vol.64, issue.3, pp.715-720, 1997.
DOI : 10.1016/S0003-4975(97)00757-1

R. Lelis, J. Krieger, A. Pereira, A. Schmidt, M. Carmona et al., Apolipoprotein E4 genotype increases the risk of postoperative cognitive dysfunction in patients undergoing coronary artery bypass graft surgery, J Cardiovasc Surg, vol.47, pp.451-456, 2006.

E. Heyer, D. Wilson, D. Sahlein, J. Mocco, S. Williams et al., APOE-??4 predisposes to cognitive dysfunction following uncomplicated carotid endarterectomy, Neurology, vol.65, issue.11, pp.1759-1763, 2005.
DOI : 10.1212/01.wnl.0000184579.23624.6b

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1524823

L. Steed, R. Kong, J. Stygall, J. Acharya, M. Bolla et al., The role of apolipoprotein E in cognitive decline after cardiac operation, The Annals of Thoracic Surgery, vol.71, issue.3, pp.823-826, 2001.
DOI : 10.1016/S0003-4975(00)02511-X

J. Mathew, M. Podgoreanu, H. Grocott, W. White, R. Morris et al., Genetic Variants in P-Selectin and C-Reactive Protein Influence Susceptibility to Cognitive Decline After Cardiac Surgery, Journal of the American College of Cardiology, vol.49, issue.19, pp.1934-1942, 2007.
DOI : 10.1016/j.jacc.2007.01.080

B. Silbert, L. Evered, D. Scott, and T. Cowie, The Apolipoprotein E ??4 Allele is not Associated With Cognitive Dysfunction in Cardiac Surgery, The Annals of Thoracic Surgery, vol.86, issue.3, pp.841-847, 2008.
DOI : 10.1016/j.athoracsur.2008.04.085

H. Abildstrom, M. Christiansen, V. Siersma, and L. Rasmussen, Apolipoprotein E Genotype and Cognitive Dysfunction after Noncardiac Surgery, Anesthesiology, vol.101, issue.4, pp.855-861, 2004.
DOI : 10.1097/00000542-200410000-00009

D. Mcdonagh, J. Mathew, W. White, B. Phillips-bute, D. Laskowitz et al., Cognitive Function after Major Noncardiac Surgery, Apolipoprotein E4 Genotype, and Biomarkers of Brain Injury, Anesthesiology, vol.112, issue.4, pp.852-859, 2010.
DOI : 10.1097/ALN.0b013e3181d31fd7

K. Ritchie, M. Allard, F. Huppert, C. Nargeot, B. Pinet et al., Computerized cognitive examination of the elderly (ECO): The development of a neuropsychological examination for clinic and population use, International Journal of Geriatric Psychiatry, vol.34, issue.11, pp.899-914, 1993.
DOI : 10.1002/gps.930081104

K. Ritchie and R. Fuhrer, The validation of an informant screening test for irreversible cognitive decline in the elderly: performance characteristics within a general population sample, International Journal of Geriatric Psychiatry, vol.17, issue.2, pp.149-156, 1995.
DOI : 10.1002/(SICI)1099-1166(199602)11:2<149::AID-GPS298>3.0.CO;2-5

L. Radloff, The CES-D Scale: A Self-Report Depression Scale for Research in the General Population, Applied Psychological Measurement, vol.1, issue.3, pp.385-401, 1977.
DOI : 10.1177/014662167700100306

K. Ritchie and B. Ledesert, The measurement of incapacity in the severely demented elderly: The validation of a behavioural assessment scale, International Journal of Geriatric Psychiatry, vol.21, issue.4, pp.217-226, 1991.
DOI : 10.1002/gps.930060406

A. Dupuy, I. Carriere, J. Scali, J. Cristol, K. Ritchie et al., Lipid levels and cardiovascular risk in elderly women: a general population study of the effects of hormonal treatment and lipid-lowering agents, Climacteric, vol.5, issue.1, pp.74-83, 2008.
DOI : 10.1161/CIRCULATIONAHA.106.642280

URL : https://hal.archives-ouvertes.fr/inserm-00243077

M. Ancelin, D. Roquefeuil, G. Ledesert, B. Bonnel, F. Cheminal et al., Exposure to anaesthetic agents, cognitive functioning and depressive symptomatology in the elderly, The British Journal of Psychiatry, vol.178, issue.4, pp.360-366, 2001.
DOI : 10.1192/bjp.178.4.360

I. Iachini, A. Iavarone, V. Senese, F. Ruotolo, and G. Ruggiero, Visuospatial Memory in Healthy Elderly, AD and MCI: A Review, Current Aging Science, vol.2, issue.1, pp.43-59, 2009.
DOI : 10.2174/1874609810902010043

J. Murphy and J. Kaye, Trajectory of mild cognitive impairment onset, J Int Neuropsychol Soc, vol.14, pp.192-198, 2008.

A. Nordlund, S. Rolstad, O. Klang, K. Lind, S. Hansen et al., Cognitive profiles of mild cognitive impairment with and without vascular disease., Neuropsychology, vol.21, issue.6, pp.706-712, 2007.
DOI : 10.1037/0894-4105.21.6.706

Y. Shim, B. Yoon, Y. Shon, K. Ahn, and D. Yang, Difference of the hippocampal and white matter microalterations in MCI patients according to the severity of subcortical vascular changes: Neuropsychological correlates of diffusion tensor imaging, Clinical Neurology and Neurosurgery, vol.110, issue.6, pp.552-561, 2008.
DOI : 10.1016/j.clineuro.2008.02.021

G. Greendale, D. Kritz-silverstein, T. Seeman, and E. Barrett-connor, Higher Basal Cortisol Predicts Verbal Memory Loss in Postmenopausal Women: Rancho Bernardo Study, Journal of the American Geriatrics Society, vol.338, issue.12, pp.1655-1658, 2000.
DOI : 10.1111/j.1532-5415.2000.tb03878.x

G. Li, M. Cherrier, D. Tsuang, E. Petrie, E. Colasurdo et al., Salivary cortisol and memory function in human aging, Neurobiology of Aging, vol.27, issue.11, pp.1705-1714, 2006.
DOI : 10.1016/j.neurobiolaging.2005.09.031

T. Seeman, B. Mcewen, B. Singer, M. Albert, and J. Rowe, Increase in Urinary Cortisol Excretion and Memory Declines: MacArthur Studies of Successful Aging, Journal of Clinical Endocrinology & Metabolism, vol.82, issue.8, pp.2458-2465, 1997.
DOI : 10.1210/jc.82.8.2458

I. Beluche, I. Carriere, K. Ritchie, and M. Ancelin, A prospective study of diurnal cortisol and cognitive function in community-dwelling elderly people, Psychological Medicine, vol.48, issue.06, pp.1039-1050, 2010.
DOI : 10.1192/bjp.123.4.467

URL : https://hal.archives-ouvertes.fr/inserm-00489050

P. Keenan, M. Jacobson, R. Soleymani, and J. Newcomer, Commonly Used Therapeutic Doses of Glucocorticoids Impair Explicit Memory, Annals of the New York Academy of Sciences, vol.14, issue.1, pp.400-402, 1995.
DOI : 10.1111/j.1749-6632.1995.tb31402.x

A. Young, B. Sahakian, T. Robbins, and P. Cowen, The effects of chronic administration of hydrocortisone on cognitive function in normal male volunteers, Psychopharmacology, vol.145, issue.3, pp.260-266, 1999.
DOI : 10.1007/s002130051057

P. Mandal and J. Pettegrew, A?? peptide interactions with isoflurane, propofol, thiopental and combined thiopental with halothane: A NMR study, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1778, issue.11, pp.2633-2639, 2008.
DOI : 10.1016/j.bbamem.2008.07.002

P. Mandal, V. Simplaceanu, and V. Fodale, Intravenous Anesthetic Diazepam Does Not Induce Amyloid-?? Peptide Oligomerization but Diazepam Co-administered with Halothane Oligomerizes Amyloid-?? Peptide: An NMR Study, Journal of Alzheimer's Disease, vol.20, issue.1, pp.127-134, 2010.
DOI : 10.3233/JAD-2010-1350

J. Perucho, I. Rubio, M. Casarejos, A. Gomez, J. Rodriguez-navarro et al., Anesthesia with Isoflurane Increases Amyloid Pathology in Mice Models of Alzheimer'S Disease, Journal of Alzheimer's Disease, vol.19, issue.4, pp.1245-1257, 2010.
DOI : 10.3233/JAD-2010-1318

P. Mandal, D. Schifilliti, F. Mafrica, and V. Fodale, Inhaled anesthesia and cognitive performance, Drugs of Today, vol.45, issue.1, pp.47-54, 2009.
DOI : 10.1358/dot.2009.45.1.1315075