R. Corradetti, J. L. Ga?¨arsaga?¨arsa, and Y. Ben-ari, D-Aminophosphonovaleric acid-sensitive spontaneous giant EPSPs in immature rat hippocampal neurones, European Journal of Pharmacology, vol.154, issue.2, pp.221-222, 1988.
DOI : 10.1016/0014-2999(88)90103-3

M. C. Malenka, R. C. Desarmenien, M. G. Spitzer, N. C. Durand, G. M. Kovalchuk et al., A critical period for long-term scope Karl Zeiss microscope (water immersion objective 40) that potentiation at thalamocortical synapses allows recognition of neurons in slices. The neurons were then ap Role of calcium and proached with the Fluo3-AM containing pipette for loading. The use protein kinase C in development of the delayed rectifier potassium of a calibrated map to correlate fluorescence spots and the visual current in xenopus spinal neurons Long-term nated from the selected neurons. potentiation and functional synapse induction in developing hippo- Solutions and Drugs campus, Nature Neuron Nature, vol.375, issue.381, pp.325-328, 1991.

M. B. Feller, D. P. Wellis, D. Stellwagen, F. S. Werblin, and S. , Requirement for Cholinergic Synaptic Transmission in the Propagation of Spontaneous Retinal Waves, Fluo 3-AM and DIDS were first dissolved in DMSO, pp.1182-1187, 1996.
DOI : 10.1126/science.272.5265.1182

A. Bath-fiszman, M. L. Novotny, E. A. Lange, and G. D. Barker, In some experiments, isoguvacine was applied locally by pressure ejection from a micropipette using a, J.L, 1990.

I. Picospritzer and . Valve, Drugs used were purchased Embryonic and early postnatal hippocampal cells respond to nanofrom Sigma (NMDA, tetrodotoxin, D-600, DIDS, and protease XXIII), molar concentrations of muscimol, Dev. Brain Res, vol.0, pp.1-8

K. Fox, The critical period for long-term potentiation in primary sensory cortex, Neuron, vol.15, issue.3, pp.485-488, 1995.
DOI : 10.1016/0896-6273(95)90136-1

K. Fox, H. Sato, and N. Daw, The location and function of NMDA receptors in cat and kitten visual cortex, J. Neurosci, vol.9, pp.2443-2454, 1989.

A. Fukuda, I. Mody, P. , D. A. Miles, K. Krnjevic et al., Differential ontogenesis We thank Drs of presynaptic and postsynaptic GABA B inhibition in the rat somato- Holmes, and H. A. McLean for useful discussions and critical reading sensory cortex analysis; and B. Martin and S. Weiler for technical assistance in Modulation of GABA-mediated synaptic potentials by glutamatergic Ca 2 images processing, of the manuscript; Dr. A. Bakhramov for the help in single channels Ga?¨arsaGa?¨arsa, This work was supported by grants from agonists in neonatal CA3 rat hippocampal neurons, pp.448-452, 1990.

I. and M. Re-de-la-recherche-et-de-l-'espace, Socié té de Sec- 3, ours des Amis des Sciences, and Association Nationale de Recherche sur le SIDA (AIDS), pp.301-309

J. L. Ga?¨arsaga?¨arsa, H. Mclean, P. Congar, X. Leinekugel, R. Khazipov et al., Postnatal maturation of gamma-aminobutyric acidA and B-mediated inhibition in the CA3 hippocampal region of the rat, Journal of Neurobiology, vol.6, issue.3, pp.339-349, 1995.
DOI : 10.1002/neu.480260306

C. S. Goodman, C. J. Shatz, A. Agmon, O. Dowd, and D. K. , Developmental mechanisms NMDA receptor?mediated curthat generate precise patterns of neuronal connectivity. Cell/Neuron rents are prominent in the thalamocortical synaptic response before 72 maturation of inhibition, J. Neurophysiol, vol.10, issue.68, pp.77-98, 1992.

A. Artola and . Singer, Long-term potentiation and NMDA receptors in rat visual cortex, Nature, vol.330, issue.6149, pp.649-652, 1987.
DOI : 10.1038/330649a0

G. Barbin, H. Pollard, J. L. Ga?¨arsaga?¨arsa, Y. Ben-ari, T. G. Hales et al., Involvement of GABAA receptors in the outgrowth of cultured hippocampal neurons, Neuroscience Letters, vol.152, issue.1-2, pp.150-154, 1993.
DOI : 10.1016/0304-3940(93)90505-F

T. B. Behar, Y. Li, H. T. Tran, W. Ma, V. Dunlap et al., Early network GABA stimulates chemotaxis and chemokinesis oscillations in the developing hippocampus, Soc. Neurosci, vol.26, 1996.

M. Hara, M. Inoue, T. Yasukura, S. Ohnishi, Y. Mikami et al., Uneven distribution of intracellular Cl??? in rat hippocampal neurons, Neuroscience Letters, vol.143, issue.1-2, pp.135-138, 1988.
DOI : 10.1016/0304-3940(92)90250-B

S. Hestrin, Y. Ben-ari, E. Cherubini, R. Corradetti, and J. L. Ga?¨arsaga?¨arsa, Developmental regulation of NMDA receptor-mediated synaptic currents at a central synapse, Nature, vol.357, issue.6380, pp.686-689, 1989.
DOI : 10.1038/357686a0

K. -kaila and J. Voipio, Ionic basis of GABAA receptor channel rones function in the nervous system, Giant synaptic potentials in immature rat CA3 hippocampal neu, pp.303-325, 1994.

Y. Ben-ari, V. Tseeb, D. Raggozzino, R. Khazipov, . Ga?¨arsaga?¨arsa et al., Neuronal coupling and uncoupling -Aminobutyric acid (GABA): a fast excitatory transmitter in the developing nervous system, J.L. Curr. Opin. Neurobiol. Brain Res, vol.5, issue.102, pp.98-105, 1994.

E. D. Kanter and L. D. Haberly, Associative long-term potentiation in piriform cortex slices requires GABAA blockade, J. Neurosci, 1993.

G. Carmignoto and S. Vicini, Activity-dependent decrease in 13, pp.2477-2482, 1992.

E. D. Kanter, A. Kapur, and L. B. Haberly, A dendritic GABA Amediated IPSP regulates facilitation of NMDA-mediated responses, 1996.

G. Chen, P. Trombley, and A. N. Van-den-pol, Excitatory to burst stimulation of afferent fibers in piriform cortex actions of GABA in developing rat hypothalamic neurones, J. Neurosci. J. Phys, vol.16, issue.494, pp.307-312, 1996.

E. Cherubini, J. L. Ga?¨arsaga?¨arsa, and Y. Ben-ari, GABA: an excitcally generated cytosolic calcium pulses and their detection by atory transmitter in early postnatal life, Trends Neurosci. J. Biol. Chem, vol.14, issue.264, pp.8179-8184, 1991.

L. C. Katz, Coordinate activity in retinal and cortical, 1993.

M. Constantine-paton, H. T. Cline, and E. Debski, Patterned ment activity, synaptic convergence, and the NMDA receptor in developing visual pathways, Curr. Opin. Neurobiol. Annu. Rev. Neurosci, vol.3, issue.13, pp.93-99, 1990.

L. Nowak, P. Bregestovski, P. Ascher, A. Herbert, . Prochiantz et al., Magnesium gates glutamate-activated channels in mouse and Mg 2 block of N-Methyl-D-Aspartate receptor channels during central neurons, Kinetics A. Nature Neuroscience, vol.307, issue.69, pp.462-465, 1984.

O. Donovan, M. J. Sernagor, E. Sholomenko, G. Ho, S. Antal et al., Development of spinal motor networks in the chick embryo, Journal of Experimental Zoology, vol.21, issue.3, pp.261-273, 1992.
DOI : 10.1002/jez.1402610306

Y. , K. Van-den-pol, and A. N. , Synchronization of GABAergic interneuronal network in CA 3 subfield of neonatal rat hippocampal slices GABA neurotransmission in press. in the hypothalamus: developmental reversal from Ca elevating to depressing, Obrietan, pp.5065-5077, 1995.

A. Kirkwood, H. Lee, and M. F. Bear, Co-regulation of, 1993.

Y. Komatsu, M. Iwakiri, P. Rakic, and H. Komuro, Long-term modification of inhibi The role of receptor-channel activtory synaptic transmission in developing visual cortex. Neuroreport ity in neuronal cell migration, J. Neurobiol, vol.26, issue.4, pp.299-315, 1993.

D. Redburn and A. Schousboe, Neurotrophic activity of Lauder Neurotransmitters as growth regulatory signals: GABA during development, J.M. Neurol. Neurobiol, vol.32, pp.1-227, 1987.

W. G. Regher, D. W. Tank, X. Tseeb, V. Ben-ari, Y. Bregestovski et al., Calcium concentration dynamics produced by synaptic activation of CA1 hippocampal pyramidal Leinekugel, J. Neurosci, vol.12, pp.4202-4223, 1992.

S. A. Kater and S. B. , Mechanisms of GABA and glycine depolarization-induced calcium (Lond transients in rat dorsal horn neurons Neurotransmitter regulation, J. Physiol. J. Physiol. (Lond.), vol.487, issue.476, pp.319-329, 1989.

J. J. Loturco, M. G. Blanton, A. R. Kriegstein, J. Spitzer, and N. C. , Initial ex- Neurosci pression and endogenous activation of NMDA channels in early Rohrbough Regulation of intracellular neocortical development Cl levels by Na -dependent Cl cotransport distinguishes depolar- LoTurco, and izing from hyperpolarizing GABA A receptor-mediated responses in Kriegstein GABA and glutamate depolarize cortical prospinal neurons genitor cells and inhibit DNA synthesis, Lett. J. Neurosci. A.R. J. Neurosci. Neuron, vol.99, issue.15, pp.61-66, 1991.

G. Rusanescu, H. Qi, S. M. Thomas, J. S. Brugge, . Halegoua et al., Postnatal maturation of the S Calcium influx induces neurite growth through a Src-Ras GABAergic system in rat neocortex, J. Neurophysiol. Neuron, vol.65, issue.15, pp.247-263, 1991.

R. C. Malenka, R. A. Nicoll, W. S. Scherer, and S. B. Udin, NMDA-receptor-dependent N-methyl-D-aspartate antagosynaptic plasticity: multiple forms and mechanisms. Trends Neunists prevent interaction of binocular maps in Xenopus tectum, J. rosci, vol.16, issue.9, pp.521-527, 1989.
DOI : 10.1016/0166-2236(93)90197-t

L. Sivilotti, A. Nistri, M. L. Mayer, G. L. Westbrook, G. et al., GABA receptor mechanisms in the central nervous system, embryonic chic brain and retina. Synapse, pp.35-92, 1984.
DOI : 10.1016/0301-0082(91)90036-Z

C. Mcbain, R. Dingledine, K. J. Staley, and I. Mody, Dual-component miniature Shunting of excitatory input to excitatory synaptic currents in rat hippocampal CA3 pyramidal neudentate gyrus granule cells by a depolarizing GABAA receptor? rons, J. Neurophysiol. J. Neurophysiol, vol.68, issue.68, pp.16-27, 1992.

K. J. Staley, B. L. Soldo, and W. R. Proctor, Ionic mechanisms NMDA-dependent GABA-A-mediated polysynaptic potentials in the of neuronal excitation by inhibitory GABAA receptors. Science 269, neonatal rat hippocampal CA3 region, Eur. J. Neurosci, vol.7, pp.1442-977, 1995.

G. J. Strecker, M. B. Jackson, and F. E. Dudek, Blockade, 1994.

H. A. Mclean, O. Caillard, Y. Ben-ari, and J. L. Ga?¨arsaga?¨arsa, Bidiof NMDA-activated channels by magnesium in the immature rat rectional plasticity expressed by GABAergic synapses in the neonahippocampus, J. Neurophysiol, vol.72, pp.1538-1548, 1996.

E. Tremblay, M. Roisin, A. Represa, C. Charriaut-marlange, I. Medina et al., Transient increased density of NMDA binding P Intracellular Ca 2 inactivates NMDA currents, J. Neurosites in the developing rat hippocampus. Brain Res, vol.461, pp.393-396, 1988.

T. Tsumoto, K. Hagihara, H. Sato, Y. Hata, H. Ross et al., NMDA receptors in the visual cortex of young kittens are more effective than those of adult cats, Nature, vol.327, issue.6122, pp.513-514, 1987.
DOI : 10.1038/327513a0

N. Lisman, J. E. Johnston, D. Wang, J. Reichling, D. B. Kyrozis et al., Synaptically activated increases in Ca concentration in hippocampal CA1 cells are primarily due to voltage-gated Ca channels. Neuron 9, Developmental loss of GABA-and glycine-induced depolarization 1163?1173. and Ca transients in embryonic rat dorsal horn neurons in culture, Eur. J. Neurosci, vol.6, pp.1275-1280, 1992.

H. Monyer, N. Burnashev, D. Laurie, B. Sakmann, P. H. Seeburg et al., Developmental and regional expression in the rat brain Wigstrom Facilitated induction of and functional properties of four NMDA receptors. Neuron 12, hippocampal long-lasting potentiation during blockade of inhibition, Nature, vol.270, pp.529-540, 1983.

R. O. Wong, M. Meister, C. J. Shatz, W. , C. et al., Transient period of correlated bursting activity during development of the mammalian retina, Neuron, vol.11, issue.5, pp.923-938, 1991.
DOI : 10.1016/0896-6273(93)90122-8

W. L. Wu, L. Ziskind-conhaim, and M. A. Sweet, Early development of glycine-and GABA-mediated synapses in rat spinal cord, J. Neurosci, vol.12, pp.3935-3945, 1992.

R. Yuste and L. C. Katz, Control of postsynaptic Ca2+ influx in developing neocortex by excitatory and inhibitory neurotransmitters, Neuron, vol.6, issue.3, pp.333-344, 1991.
DOI : 10.1016/0896-6273(91)90243-S

R. Yuste, D. A. Nelson, W. W. Rubin, and L. C. Katz, Neuronal domains in developing neocortex: Mechanisms of coactivation, Neuron, vol.14, issue.1, pp.7-17, 1995.
DOI : 10.1016/0896-6273(95)90236-8

L. Zhang, I. Spigelman, C. , and P. L. , Development of GABA-mediated, chloride-dependent inhibition in CA1 pyramidal neurones of immature rat hippocampal slices., The Journal of Physiology, vol.444, issue.1, pp.25-49, 1991.
DOI : 10.1113/jphysiol.1991.sp018864