V. Anantharam, R. Panchal, A. Wilson, W. Kolchine, S. Treistman et al., Combinatorial RNA splicing alters the surface charge on the NMDA receptor, FEBS Letters, vol.15, issue.1, pp.27-30, 1992.
DOI : 10.1016/0014-5793(92)80648-Z

Y. Ben-ari and M. Gho, Long-lasting modification of the synaptic properties of rat CA3 hippocampal neurones induced by kainic acid., The Journal of Physiology, vol.404, issue.1, 1988.
DOI : 10.1113/jphysiol.1988.sp017294

S. Cornish and H. Wheal, Long-term loss of paired pulse inhibition in the kainic acid-lesioned hippocampus of the rat, Neuroscience, vol.28, issue.3, pp.563-71, 1989.
DOI : 10.1016/0306-4522(89)90005-5

G. Durand, P. Gregor, X. Zheng, M. Bennett, G. Uhl et al., Cloning of an apparent splice variant of the rat N-methyl-Daspartate receptor NMDAR1 with altered sensitivity to polyamines and activators of protein kinase C, Proc. Natl. Acad. Sci. USA, pp.9359-63, 1992.

M. Ehlers, W. Tingley, and R. Huganir, Regulated subcellular distribution of the NR1 subunit of the NMDA receptor, Science, vol.269, issue.5231, pp.1734-1741, 1995.
DOI : 10.1126/science.7569904

M. Ehlers, S. Zhang, J. Bernhardt, and R. Huganir, Inactivation of NMDA Receptors by Direct Interaction of Calmodulin with the NR1 Subunit, Cell, vol.84, issue.5, pp.745-55, 1996.
DOI : 10.1016/S0092-8674(00)81052-1

L. Friedman, D. Pellegrini-giampietro, E. Sperber, M. Bennett, S. Moshé et al., KA-induced status epilepticus alters glutamate and GABA A receptor gene expression in adult rat hippocampus: an in situ hybridization study, J. Neuroscience, vol.14, pp.2697-707, 1994.

C. Gall, K. Sumikawa, and G. Lynch, Levels of mRNA for a putative KA receptor are affected by seizures, Proc. Natl. Acad. Sci. USA, pp.113-136, 1990.

M. Gilbert, The NMDA-receptor antagonist, MK-801, suppresses limbic kindling and kindled seizures, Brain Research, vol.463, issue.1, pp.90-99, 1988.
DOI : 10.1016/0006-8993(88)90530-6

M. Hollmann, J. Boulter, C. Maron, L. Beasley, J. Sullivan et al., Zinc potentiates agonist-lnduced currents at certain splice variants of the NMDA receptor, Neuron, vol.10, issue.5, pp.943-954, 1993.
DOI : 10.1016/0896-6273(93)90209-A

M. Hollmann and S. Heinemann, Cloned Glutamate Receptors, Annual Review of Neuroscience, vol.17, issue.1, pp.31-108, 1994.
DOI : 10.1146/annurev.ne.17.030194.000335

D. Hosford, B. Crain, Z. Cao, D. Bonhaus, A. Friedman et al., Increased AMPAsensitive quisqualate receptor binding and reduced NMDA receptor binding in epileptic human hippocampus, J. Neurosci, vol.11, pp.428-462, 1991.

D. Johnston and T. Brown, Mechanisms of neuronal burst generation, Electrophysiology of Epilepsy, pp.227-301, 1984.

W. Kamphuis, H. Monyer, T. De-rijk, and F. Lopes-da-silva, Hippocampal kindling increases the expression of glutamate receptor-A flip and -B flip mRNA in dentate granule cells, Neuroscience Letters, vol.148, issue.1-2, pp.51-55, 1992.
DOI : 10.1016/0304-3940(92)90802-E

M. Khrestchatisky, L. Ferhat, G. Charton, A. Bernard, H. Pollard et al., Molecular correlates between reactive and developmental plasticity in the rat hippocampus, Journal of Neurobiology, vol.9, issue.3, pp.426-462, 1995.
DOI : 10.1002/neu.480260314

J. Kraus, G. Yeh, D. Bonhaus, J. Nadler, and J. Mcnamara, Kindling induces the long-lasting expression of a novel population of NMDA receptors in hippocampal region CA3, J. Neurosci, vol.14, pp.4196-205, 1994.

D. Laurie and P. Seeburg, Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA, J. Neurosci, vol.14, pp.3180-94, 1994.

Z. Magloczky and T. Freund, Delayed cell death in the contralateral hippocampus following kainate injection into the CA3 subfield, Neuroscience, vol.66, issue.4, pp.847-60, 1995.
DOI : 10.1016/0306-4522(94)00613-A

D. Martin, J. Mcnamara, and J. Nadler, Kindling enhances sensitivity of CA3 hippocampal pyramidal cells to NMDA, J. Neurosci, vol.12, pp.1928-1963, 1992.

J. Mcdonald, E. Garofalo, T. Hood, J. Sackellares, S. Gilman et al., Altered excitatory and inhibitory amino acid receptor binding in hippocampus of patients with temporal lobe epilepsy, Annals of Neurology, vol.13, issue.5, pp.529-570, 1991.
DOI : 10.1002/ana.410290513

J. Mcnamara, R. Russel, L. Rigsbee, and D. Bonhaus, Anticonvulsant and antiepileptogenic actions of MK-801 in the kindling and electroshock models, Neuropharmacology, vol.27, issue.6, pp.563-571, 1988.
DOI : 10.1016/0028-3908(88)90176-1

I. Medina, N. Filipova, A. Bakhramov, and P. Bregestovski, Calcium-induced inactivation of NMDA receptor-channels evolves independently of run-down in cultured rat brain neurones., The Journal of Physiology, vol.495, issue.2, pp.411-438, 1996.
DOI : 10.1113/jphysiol.1996.sp021603

I. Medina, N. Filipova, G. Barbin, Y. Ben-ari, and P. Bregestovski, Kainate-induced inactivation of NMDA currents via an elevation of intracellular Ca 2 in hippocampal neurons, J. Neurophysiol, vol.72, pp.456-65, 1994.

I. Medina, N. Filipova, G. Charton, S. Rougeole, Y. Ben-ari et al., Calcium-dependent inactivation of heteromeric NMDA receptor-channels expressed in human embryonic kidney cells., The Journal of Physiology, vol.482, issue.3, pp.567-73, 1995.
DOI : 10.1113/jphysiol.1995.sp020540

I. Mody and U. Heinemann, NMDA receptors of dentate gyrus granule cells participate in synaptic transmission following kindling, Nature, vol.326, issue.6114, pp.701-705, 1987.
DOI : 10.1038/326701a0

J. Nadler, B. C. Perry, and C. W. Cotman, Selective reinnervation of © hippocampal area CA1 and the fascia dentata after destruction of CA3- CA4 afferents with kainic acid, European Neuroscience Association, European Journal of Neuroscience Brain Res, vol.10, issue.182, pp.497-507, 1980.

J. Nadler, B. Perry, C. Gentry, and C. Cotman, Loss and reacquisition of hippocampal synapses after selective destruction of CA3???CA4 afferents with kainic acid, Brain Research, vol.191, issue.2, pp.387-403, 1980.
DOI : 10.1016/0006-8993(80)91289-5

S. Nakajima, J. Franck, D. Bilkey, and P. Schwartzkroin, Local circuit synaptic interactions between CA1 pyramidal cells and interneurons in the kainate-lesioned hyperexcitable hippocampus, Hippocampus, vol.49, issue.1, pp.67-78, 1991.
DOI : 10.1002/hipo.450010107

N. Nakanishi, R. Axel, and N. Shneider, Alternative splicing generates functionally distinct N-methyl-D-aspartate receptors., Proc. Natl Acad. Sci. USA, pp.8552-8558, 1992.
DOI : 10.1073/pnas.89.18.8552
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC49958

E. Nedivi, D. Hevroni, D. Naot, D. Israeli, and Y. Citri, Numerous candidate plasticity-related genes revealed by differential cDNA cloning, Nature, vol.363, issue.6431, pp.718-740, 1993.
DOI : 10.1038/363718a0

R. Neuman, Y. Ben-ari, and E. Cherubini, Antagonism of spontaneous and evoked bursts by 6-cyano-7-nitroquinoxaline-2, 3-dione (CNQX) in the CA3 region of the in vitro hippocampus, Brain Research, vol.474, issue.1, pp.201-204, 1988.
DOI : 10.1016/0006-8993(88)90686-5

R. Neuman, Y. Ben-ari, and E. Cherubini, Epileptiform bursts elicited in CA3 hippocampal neurons by a variety of convulsants are not blocked by N-methyl-d-aspartate antagonists, Brain Research, vol.459, issue.2, pp.265-74, 1988.
DOI : 10.1016/0006-8993(88)90642-7

M. Okazaki, D. Evenson, and J. Nadler, Hippocampal mossy fiber sprouting and synapse formation after status epilepticus in rats: Visualization after retrograde transport of biocytin, The Journal of Comparative Neurology, vol.76, issue.4, pp.515-549, 1995.
DOI : 10.1002/cne.903520404

M. Paupard, L. Friedman, and R. Zukin, Developmental regulation and cell-specific expression of N-methyl-d-aspartate receptor splice variants in rat hippocampus, Neuroscience, vol.79, issue.2, pp.399-409, 1997.
DOI : 10.1016/S0306-4522(96)00677-X

D. Pellegrini-giampetro, W. Pulsinelli, and S. Zukin, NMDA and Non-NMDA Receptor Gene Expression Following Global Brain Ischemia in Rats: Effect of NMDA and Non-NMDA Receptor Antagonists, Journal of Neurochemistry, vol.252, issue.3, pp.1067-73, 1994.
DOI : 10.1046/j.1471-4159.1994.62031067.x

D. Peterson, J. Collins, and H. Bradford, The kindled amygdala model of epilepsy: anticonvulsant action of amino acid antagonists, Brain Research, vol.275, issue.1, pp.169-72, 1983.
DOI : 10.1016/0006-8993(83)90431-6

S. Phelps, J. Mitchell, and H. Wheal, Changes to synaptic ultrastructure in field CA1 of the rat hippocampus following intracerebroventricular injection of kainic acid, Neuroscience, vol.40, issue.3, pp.687-99, 1991.
DOI : 10.1016/0306-4522(91)90005-9

H. Pollard, S. Cantagrel, C. Charriaut-marlangue, J. Moreau, and Y. Ben-ari, Apoptosis associated DNA fragmentation in epileptic brain damage, NeuroReport, vol.5, issue.9, pp.1053-1058, 1994.
DOI : 10.1097/00001756-199405000-00009

H. Pollard, C. Charriaut-marlangue, S. Cantagrel, A. Represa, O. Robain et al., Kainate-induced apoptotic cell death in hippocampal neurons, Neuroscience, vol.63, issue.1, pp.7-18, 1994.
DOI : 10.1016/0306-4522(94)90003-5

H. Pollard, A. Héron, Y. Ben-ari, and M. Khrestchatisky, Alterations of the GluR-B AMPA receptor subunit flip/flop expression in kainate-induced epilepsy and ischemia, Neuroscience, vol.57, issue.3, pp.545-54, 1993.
DOI : 10.1016/0306-4522(93)90004-Y

H. Pollard, M. Khrestchatisky, J. Moreau, Y. Ben-ari, and A. Represa, Correlation between reactive sprouting and microtubule protein expression in epileptic hippocampus, Neuroscience, vol.61, issue.4, pp.61-773, 1994.
DOI : 10.1016/0306-4522(94)90401-4

G. Pratt, M. Kokaia, J. Bengzon, Z. Kokaia, J. Fritschy et al., Differential regulation of N-methyl-d-aspartate receptor subunit messenger RNAs in kindling-induced epileptogenesis, Neuroscience, vol.57, issue.2, pp.307-325, 1993.
DOI : 10.1016/0306-4522(93)90064-M

A. Rafiki, H. Gozlan, Y. Ben-ari, M. Khrestchatisky, and I. Medina, The calcium-dependent transient inactivation of recombinant NMDA receptor-channel does not involve the high affinity calmodulin binding site of the NR1 subunit, Neuroscience Letters, vol.223, issue.2, pp.137-146, 1997.
DOI : 10.1016/S0304-3940(97)13413-9

A. Represa and Y. Ben-ari, Sprouting and synaptogenesis of hippocampal mossy fibers in epileptic rats, Epileptic Seizures and Syndromes, pp.539-584, 1994.

A. Represa, I. Jorquera, L. Gal-la-salle, G. Ben-ari, and Y. , Epilepsy induced collateral sprouting of hippocampal mossy fibers: Does it induce the development of ectopic synapses with granule cell dendrites?, Hippocampus, vol.5, issue.3, pp.257-68, 1993.
DOI : 10.1002/hipo.450030303

A. Represa, E. Tremblay, and Y. Ben-ari, Kainate binding sites in the hippocampal mossy fibers: Localization and plasticity, Neuroscience, vol.20, issue.3, pp.739-787, 1987.
DOI : 10.1016/0306-4522(87)90237-5

A. Represa, L. Gall-la-salle, G. Ben-ari, and Y. , Hippocampal plasticity in the kindling model of epilepsy in rats, Neuroscience Letters, vol.99, issue.3, pp.345-50, 1989.
DOI : 10.1016/0304-3940(89)90471-0

A. Represa, O. Robain, E. Tremblay, and Y. Ben-ari, Hippocampal plasticity in childhood epilepsy, Neuroscience Letters, vol.99, issue.3, pp.351-356, 1989.
DOI : 10.1016/0304-3940(89)90472-2

A. Represa, J. Niquet, H. Pollard, and Y. Ben-ari, Cell death, gliosis, and synaptic remodeling in the hippocampus of epileptic rats, Journal of Neurobiology, vol.90, issue.3, pp.413-438, 1995.
DOI : 10.1002/neu.480260313

S. Rivera, E. Tremblay, S. Timsit, O. Canals, Y. Ben-ari et al., Tissue inhibitor of metalloproteases-1 (TIMP-1) is differentially induced in neurons and astrocytes after seizures: evidence for developmental, immediate early gene, and lesion response, J. Neurosci, vol.17, pp.4223-4258, 1997.

L. Simpson, H. Wheal, and R. Williamson, The contribution of non-NMDA and NMDA receptors to graded bursting activity in the CA1 region of the hippocampus in a chronic model of epilepsy, Canadian Journal of Physiology and Pharmacology, vol.69, issue.7, pp.1091-1099, 1991.
DOI : 10.1139/y91-161

R. Sloviter, Possible functional consequences of synaptic reorganization in the dentate gyrus of kainate-treated rats, Neuroscience Letters, vol.137, issue.1, pp.91-97, 1992.
DOI : 10.1016/0304-3940(92)90306-R

H. Sugihara, K. Moriyoshi, T. Ishii, M. Masu, and S. Nakanishi, Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing, Biochemical and Biophysical Research Communications, vol.185, issue.3, pp.826-858, 1992.
DOI : 10.1016/0006-291X(92)91701-Q

L. Sundstrom, J. Mitchell, and H. Wheal, Bilateral reorganisation of mossy fibres in the rat hippocampus after a unilateral intracerebroventricular kainic acid injection, Brain Research, vol.609, issue.1-2, pp.321-327, 1993.
DOI : 10.1016/0006-8993(93)90890-Y

M. Sussman, S. Sakhi, G. Tocco, I. Najm, M. Baudry et al., Neural tropomodulin: developmental expression and effect of seizure activity, Developmental Brain Research, vol.80, issue.1-2, pp.45-53, 1994.
DOI : 10.1016/0165-3806(94)90088-4

D. Tauck and J. Nadler, Evidence for functional mossy fiber © sprouting in hippocampal formation of kainic acid treated rats, European Neuroscience Association, European Journal of Neuroscience J. Neuroscience, vol.10, issue.5, pp.497-507, 1985.

D. Turner and H. Wheal, Excitatory synaptic potentials in kainic acid-denervated rat CA1 pyramidal neurons, J. Neurosci, vol.11, pp.2786-94, 1991.

A. Vezzani, C. Speciale, D. Vedova, F. Tamburin, M. Benatti et al., Alternate splicing at the C-terminal but not at the N-terminal domain of the NMDA receptor NR1 is altered in the kindling hippocampus, 1995.

H. Wheal, Function of synapses in the CA1 region of the hippocampus: Their contribution to the generation or control of epileptiform activity, Comparative Biochemistry and Physiology Part A: Physiology, vol.93, issue.1, pp.211-231, 1989.
DOI : 10.1016/0300-9629(89)90209-0

H. Wheal, L. Simpson, S. Phelps, and E. Stockley, Excitatory amino acid receptor subtypes and their roles in epileptiform synaptic potentials in the hippocampus, Excitatory Amino Acids and Synaptic Function, pp.239-64, 1991.

M. Yamazaki, H. Mori, K. Araki, K. Mori, and M. Mishina, Cloning, expression and modulation of a mouse NMDA receptor subunit, FEBS Letters, vol.252, issue.1, pp.39-45, 1992.
DOI : 10.1016/0014-5793(92)80160-I

G. Yeh, D. Bonhaus, J. Nadler, and J. Mcnamara, Nmethyl-D-aspartate receptor plasticity in kindling: quantitative and qualitative alterations. in the N-methyl-D-aspartate receptor-channel complex, Proc. Natl Acad. Sci.USA, pp.8157-60, 1989.