J. Glessner-31 and N. M. Goldberg, Hakon Hakonarson 31 Gillian Hughes 1 , Vanessa Hus 19 , Roberta Igliozzi 13

J. R. Parr, Abdul Noor 51 , Gudrun Nygren 30, Melhem Barbara Parrini Aparna Prasad Jiannis Ragoussis Jessica Rickaby Rice, vol.2, issue.58

L. Sheffield-59 and . Soorya, Raffaella Tancredi 13 , Katherine Tansey 1 , Bhooma Thiruvahindrapduram 3 , Ann P. Thompson 32

G. Autism, . Group, and J. W. Psychotherapy, 3 The Centre for Applied Genomics and Program in The Hospital for Sick Children and Department of Molecular Genetics 4 School of Medicine and Medical Science University College, Dublin 4, Ireland. 5 Instituto Nacional de Saude Dr Ricardo Jorge and Instituto Gulbenkian de Cîencia, 1649-016 Lisbon, Portugal. 6 BioFIG -Center for Biodiversity, Functional & Integrative Genomics, Campus da FCUL, C2.2.12, Campo Grande, 8 Wellcome Trust Centre for Human Genetics. 13 Stella Maris Institute for Child and Adolescent Neuropsychiatry Italy. 14 Child and Adolescent Mental Health, pp.1749-1765

. Pasteur, The Hospital for Sick Children and Bloorview Kids Rehabilitation 22 Autism Speaks 23 Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, 27599, USA. 24 Department of Child Psychiatry The Netherlands. 25 APHP, Hôpital Robert Debré, Child and Adolescent Psychiatry, 75019 Paris, France. 26 Department of Speech and Hearing Sciences 27 Disciplines of Genetics and Medicine, Memorial University of Newfoundland, St. John's Newfoundland, A1B 3V6, Canada. 28 The John P. Hussman Institute for Human Genomics 30 Department of Child and Adolescent Psychiatry 31 The Center for Applied Genomics, Division of Human Genetics, The Children's Hospital of Philadelphia 33 Academic Department of Child Psychiatry, Booth Hall of Children's Hospital 35 Department of Pediatrics, Children's Hospital of Philadelphia 37 The Seaver Autism Center for Research and Treatment, 17 Human Genetics and Cognitive Functions. 36 Division of Molecular Genome Analysis Nathan Kline Institute for Psychiatric Research (NKI), pp.39-90036, 19104.

. Old-orangeburg-road and . Orangeburg, 47 Psychiatry Department, University of Utah Medical School, Salt Lake City, Utah 84108, USA. 48 Departments of Psychiatry and Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213. 49 Department of Psychiatry and Behavioral Sciences 50 Department of Human Genetics, University of California -Los Angeles School of Medicine 51 Centre for Addiction and Mental Health Agia Sophia Children's Hospital, 115 27 Athens, Greece. 53 Institutes of Neuroscience and Health and Society, 55 Carolina Institute for Developmental Disabilities Social, Genetic and Developmental Psychiatry Centre, pp.27599-3366

S. Louis, . Of-medicine, . St, and . Louis, 61 Child Study Centre 62 Department of Psychiatry, Carver College of Medicine, Iowa City, Iowa 52242, USA. 63 Department of Pediatrics The Research Institute at Nationwide Children's Hospital and The Ohio State University § Lead AGP investigators who contributed equally to this project. X Deceased *Correspondence should be addressed to Bernie Devlin, 68 Departments of Biostatistics and Medicine, pp.412-246, 19104.