W. T. Beck, Mechanisms of multidrug resistance in human tumor cells. The roles of P-glycoprotein, DNA topoisomerase II, and others factors, Cancer Treat Rev, vol.17, pp.11-20, 1990.

Y. A. Hannun, Apoptosis and the dilemma of cancer chemotherapy, Blood, vol.89, pp.1845-1853, 1997.

P. Borst, R. Evers, M. Kool, and J. Winjholds, A family of drug transporters: the multidrug resistance-associated proteins, J Natl Cancer Inst, vol.92, issue.16, pp.1295-1302, 2000.

M. M. Gottesman, T. Fojo, and S. E. Bates, Multidrug resistance in cancer: Role of ATP-dependant transporters, Nature, vol.2, pp.48-58, 2002.

M. M. Gottesman and I. Pastan, Biochemistry of multidrug resistance mediated by the multidrug transporter, Ann Rev Biochem, vol.62, pp.385-427, 1993.

R. L. Juliano and V. Ling, A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants, Biochim Biophys Acta, vol.455, pp.152-162, 1976.

K. Ueda, M. M. Cornwell, M. M. Gottesman, I. Pastan, I. B. Roninson et al., The MDR1 gene, reponsible for multidrug resistance, codes for P-glycoprotein, Biochim Biophys Res Comm, vol.141, issue.3, pp.956-962, 1986.

C. J. Chen, J. E. Chin, K. Ueda, D. P. Clark, I. Pastan et al., Internal duplication and homology with bacterial transport proteins in the MDR1 (P-glycoprotein) gene from multidrug-resistant human cells, Cell, vol.47, pp.381-389, 1986.

S. P. Cole, G. Bhardwaj, J. H. Gerlach, J. E. Mackie, C. E. Grant et al., Overexpression of a transporter gene in a multidrug-resistance human lung cancer line, Science, vol.258, pp.1650-1654, 1992.

C. E. Grant, G. Valdimarsson, D. R. Hipfner, K. C. Almquist, C. Spc et al., Overexpression of multidrug resistanceassociated protein (MRP) increases resistance to natural drugs, Cancer Res, vol.54, pp.357-361, 1994.

P. Borst, R. Evers, M. Kool, and J. Winjholds, The multidrug resistance protein family, Biochim Biophys Acta, vol.1461, pp.347-357, 1999.

Z. Benderra, A. M. Faussat, L. Sayada, J. Y. Perrot, D. Chaoui et al., Breast cancer resistance protein and Pglycoprotein in 149 adult acute myeloid leukemias, Clin Cancer Res, vol.10, pp.7896-7902, 2004.

T. Litman, T. E. Druley, W. D. Stein, and S. E. Bates, From MDR to MXR; new understanding of multidrug resistance systems, their properties and clinical signifiance, Cell Mol Life Sci, vol.58, pp.931-959, 2001.

I. Klein, B. Sarkadi, and A. Varadi, An inventory of the human ABC proteins, Biochim Biophys Acta, vol.1461, pp.237-262, 1999.

E. Teodori, S. Dei, S. Scapecchi, and F. Gualtieri, The medicinal chemistry of multi-drug resistance (MDR) reversing drugs, Il Farmaco, vol.57, pp.385-415, 2002.

T. Tsuruo, H. Iida, and S. Tsukagoshi, Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil, Cancer Res, vol.41, 1967.

A. Grossi and M. Biscardi, Reversal of MDR by verapamil analogues, Hematology, vol.9, issue.1, pp.47-56, 2004.

G. Toffoli, F. Simone, G. Corona, M. Raschack, B. Cappelletto et al., Structure-activity relationship of verapamil analogs and reversal of multidrug resistance, Biochem Pharmacol, vol.50, issue.8, pp.1245-1255, 1995.

D. Berger, R. Citarella, M. Dutia, L. Greenberger, W. Hallett et al., Novel multidrug resistance reversal agents, J Med Chem, vol.42, pp.2145-2161, 1999.

E. Pereira, E. Teodori, S. Dei, F. Gualtieri, and . Garnier-suillerot, A: Reversal of multidrug resistance by verapamil analogues, Biochem Pharmacol, vol.50, issue.4, pp.451-457, 1995.

E. Teodori, S. Dei, P. Quidu, R. Budriesi, A. Chiarini et al., Design, synthesis and in vitro activity of catamphilic reverters of multidrug resistance: Discovery of a selective, highly efficacious chemosensitizer with potency in the nanomolar range, J Med Chem, vol.42, pp.1687-1697, 1999.

S. Dei, E. Teodori, A. Garnier-suillerot, F. Gualtieri, S. Scapecchi et al., Structure-activity relationships 2-(3,4-dimethoxyphenyl)-5-(9-fluorenylamino)-2-(methylethyl) pentanenitrile and its N-methyl derivative, Bioorg Med Chem, vol.9, pp.2673-2682, 2001.

M. Biscardi, E. Teodori, R. Caporale, R. Budriesi, F. Balestri et al., Multidrug reverting activity toward leukemia cells in a group of new verapamil analogues with low cardiovascular activity, Leukemia Res, vol.30, pp.1-8, 2006.

R. Barattin, Synthèse et évaluation biologique de nouveaux inhibiteurs de Pgp et MRP-1, 2003.

F. Bois, C. Beney, A. Boumendjel, A. M. Mariotte, G. Conseil et al., Halogenated chalcones with high affinity binding to P-glycoprotein: potential modulators of multidrug resistance, J Med Chem, vol.41, pp.4161-4164, 1998.
URL : https://hal.archives-ouvertes.fr/hal-00313626

D. S. Im, C. S. Cheong, S. H. Lee, H. Park, and B. H. Youn, Enzymecatalyzed improved resolution of (RS)-4-cyano-4-(3,4-dimethoxyphenyl)-4-isopropyl-1-butanol, Tet Assym, vol.10, pp.3759-3767, 1999.

T. Gajda, A. Koziara, S. Zawadzki, and A. Zwierzak, Phasetransfer-catalyzed N-alkylation of N-substitued formamidesalternative procedure for the Ritter reaction, Synth Comm, vol.79, pp.549-552, 1979.

G. D. Yadav and Y. B. Jadhav, Novelties of solid-liquid phase transfer catalysed synthesis of ?-isopropyl-p-chlorophenyl acetonitrile from p-chlorophenyl acetonitrile, Org Proc Res Dev, vol.7, issue.4, pp.588-598, 2003.

T. Kometani, D. S. Watt, and J. T. , Iodination of phenols using chloramine T and sodium iodide, Tet Lett, vol.26, issue.17, pp.2043-2046, 1985.

T. Anmann, R. Guzun, N. Beraud, S. Pelloux, A. V. Kuznetsov et al., Different kinetics of the regulation of respiration in permeabilized cardiomyocytes and in HL-1 cardiac cells. Importance of cell structure/organization for respiration regulation, Biochim Biophys Acta, vol.1757, pp.1597-1606, 2006.

Y. Lu, T. Shi, Y. Wang, H. Yang, X. Yan et al., Halogen bondings-a novel interaction for rational drug design, J Med Chem, vol.52, pp.2854-2862, 2009.