J. Botto, J. Chabry, P. Sarret, J. Vincent, and J. Mazella, Stable Expression of the Mouse Levocabastine-Sensitive Neurotensin Receptor in HEK 293 Cell Line: Binding Properties, Photoaffinity Labeling, and Internalization Mechanism, Biochemical and Biophysical Research Communications, vol.243, issue.2
DOI : 10.1006/bbrc.1997.8071

J. Botto, E. Guillemare, J. Vincent, and J. Mazella, Effect of SR 48692 on neurotensininduced calcium-activated chloride currents in the Xenopus oocyte expression system: agonist-like activity on the levocabastine-sensitive neurotensin receptor and absence of antagonist effect on the levocabastine-insensitive neurotensin receptor

J. Bozou, S. Amar, J. Vincent, and P. Kitabgi, Neurotensin-mediated inhibition of cyclic AMP formation in neuroblastoma N1E115 cells: involvement of the inhibitory GTP-binding component of adenylate cyclase, Mol Pharmacol, vol.29, pp.489-96, 1986.

J. Bozou, F. De-nadai, J. Vincent, and P. Kitabgi, Neurotensin, bradykinin and somatostatin inhibit cAMP production in neuroblastoma N1E115 cells via both pertussis toxin sensitive and insensitive mechanisms, Biochemical and Biophysical Research Communications, vol.161, issue.3, pp.1144-50, 1989.
DOI : 10.1016/0006-291X(89)91361-2

J. Bozou, N. Rochet, I. Magnaldo, J. Vincent, P. Kitabgi et al., Neurotensin stimulates inositol trisphosphate-mediated calcium mobilization but not protein kinase C activation in HT29 cells Involvement of a G-protein The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalamus, Biochem J J. Biol. Chem, vol.26413, issue.248, pp.871-879, 1973.

R. Carraway and S. Mitra, Neurotensin enhances agonist-induced cAMP accumulation in PC3 cells via Ca 2+ -dependent adenylyl cyclase(s), Mol. Cell

E. Dicou, J. Vincent, and J. Mazella, Involvement of the neurotensin receptor subtype NTR3 in the growth effect of neurotensin on cancer cell lines Neurotensin receptor-3/sortilin mediates neurotensin-induced cytokine/chemokine expression in a murine microglial cell line, Int. J. Cancer J, vol.9218, pp.505-514, 2001.

P. Gailly and M. Najimi, Hermans E Evidence for the dual coupling of the rat neurotensin receptor with pertussis toxin sensitive and insensitive G-proteins, FEBS Lett, vol.20483, pp.109-122, 2000.

L. Gendron, A. Perron, M. Payet, N. Gallo-payet, P. Sarret et al., Lowaffinity neurotensin signaling: internalisation-dependent activation of ERK1

M. Goedert, R. Pinnock, C. Downes, P. Mantyh, and P. Emson, Neurotensin stimulates inositol phospholipid hydrolysis in rat brain slices, Brain Research, vol.323, issue.1, pp.1421-1451, 1984.
DOI : 10.1016/0006-8993(84)90288-9

E. Hermans, M. Geurts, and J. Maloteaux, Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors Agonist and antagonist modulation of, GTP?S binding in transfected CHO cells expressing the neurotensin receptor. Br, pp.25-44, 2003.

E. Hermans, J. Octave, and J. Maloteaux, Interaction of the COOH-terminal domain of the neurotensin receptor with a G protein does not control the phospholipase C activation but is involved in the agonist-induced internalization

B. Holst, N. Holliday, A. Bach, C. Elling, H. Cox et al., Common structural basis for constitutive activity of the ghrelin receptor family Neurotensin regulates growth of human pancreatic cancer, J. Biol. Chem. Ann. Surg, vol.27931, issue.217, pp.53806-53823, 1993.

T. Kenakin, Agonist-receptor efficacy II: agonist trafficking of receptor signals, Trends in Pharmacological Sciences, vol.16, issue.7
DOI : 10.1016/S0165-6147(00)89032-X

T. Kenakin, Inverse, protean, and ligand-selective agonism: matters of receptor conformation, The FASEB Journal, vol.15, issue.3, pp.598-611, 2001.
DOI : 10.1096/fj.00-0438rev

T. Kenakin and O. Onaran, The ligand paradox between affinity and efficacy: can you be there and not make a difference?, Trends in Pharmacological Sciences, vol.23, issue.6, pp.275-80, 2002.
DOI : 10.1016/S0165-6147(02)02036-9

C. Labbe-jullie, S. Barroso, D. Nicolas-eteve, J. Reversat, J. Botto et al., Mutagenesis and Modeling of the Neurotensin Receptor NTR1: IDENTIFICATION OF RESIDUES THAT ARE CRITICAL FOR BINDING SR 48692, A NONPEPTIDE NEUROTENSIN ANTAGONIST, Journal of Biological Chemistry, vol.273, issue.26
DOI : 10.1074/jbc.273.26.16351

C. Labbe-jullie, I. Dubuc, A. Brouard, S. Doulut, E. Bourdel et al., In vivo and in vitro structure-activity studies with peptide and pseudopeptide neurotensin analogs suggest the existence of distinct central neurotensin receptor subtypes

P. Leff, C. Scaramellini, C. Law, and K. Mckechnie, A three-state receptor model of agonist action, Trends in Pharmacological Sciences, vol.18, issue.4, pp.355-62, 1997.
DOI : 10.1016/S0165-6147(97)90664-7

H. Maeno, K. Yamada, Y. Santo-yamada, K. Aoki, and Y. Sun, Comparison of mice deficient in the high- or low-affinity neurotensin receptors, Ntsr1 or Ntsr2, reveals a novel function for Ntsr2 in thermal nociception, Brain Research, vol.998, issue.1, pp.122-131, 2004.
DOI : 10.1016/j.brainres.2003.11.039

S. Martin, J. Botto, J. Vincent, and J. Mazella, Pivotal role of an aspartate residue in sodium sensitivity and coupling to G proteins of neurotensin receptors

S. Martin, V. Navarro, J. Vincent, and J. Mazella, Neurotensin receptor-1, p.3

J. Mazella, J. Botto, E. Guillemare, T. Coppola, P. Sarret et al., Structure, functional expression and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor, J. Neurosci. J, vol.1550, pp.5613-5633, 1996.

W. Miller, R. Lefkowitz, S. Mitra, R. Carraway, R. Blute et al., Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and trafficking Agonist induced conformation alteration of neurotensin receptor and the mechanism behind inhibition of 125I-NT binding, Biol. Chem. Curr. Opin. Cell Biol. J. Rec. & Sig. Trans. Res, vol.27352, pp.26273-26279, 1998.

M. Najimi, P. Gailly, and J. Maloteaux, Distinct regions of C-terminus of the high affinity neurotensin receptor mediate the functional coupling with pertussis toxin sensitive and insensitive G-proteins, FEBS Letters, vol.55, issue.1-3, pp.329-362, 2002.
DOI : 10.1016/S0014-5793(02)02285-8

A. Nykjaer, R. Lee, K. Teng, P. Jansen, P. Madsen et al., Sortilin is essential for proNGF-induced neuronal cell death Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis, Nature J. Biol. Chem, vol.4275556, issue.276, pp.798-807, 2001.

Y. Pang, B. Cusack, K. Groshan, and E. Richelson, Proposed ligand binding site of the transmembrane receptor for neurotensin (8-13), [58] Petersen CM, pp.15060-15068, 1996.

J. Reubi, Peptide Receptors as Molecular Targets for Cancer Diagnosis and Therapy, Endocrine Reviews, vol.24, issue.4, pp.389-427, 2003.
DOI : 10.1210/er.2002-0007

F. Richard, S. Barroso, J. Martinez, C. Labbe-jullie, and P. Kitabgi, Agonism, inverse agonism, and neutral antagonism at the constitutively active human neurotensin receptor 2, Mol Pharmacol, vol.60, pp.1392-1400, 2001.

F. Richard, S. Barroso, D. Nicolas-etheve, P. Kitabgi, and C. Labbe-jullie, Impaired G protein coupling of the neurotensin receptor 1 by mutations in extracellular loop 3, European Journal of Pharmacology, vol.433, issue.1, pp.63-71, 2001.
DOI : 10.1016/S0014-2999(01)01496-0

P. Samama, S. Cotecchia, T. Costa, and R. Lefkowitz, A mutation-induced activated state of the ?2-adrenergic receptor; Extending the ternary complex model, J. Biol

A. Leysen, J. Laduron, P. Schotte, A. Rostene, W. Laduron et al., Evidence for a displaceable non-specific [3H]neurotensin binding site in rat brain Different subcellular localization of neurotensin-receptor and neurotensin-acceptor sites in the rat brain dopaminergic system Differential involvement of intracellular domains of the rat NTS1 neurotensin receptor in coupling to G proteins: a molecular basis for agonist-directed trafficking of receptor stimulus, Naunyn Schmiedeberg's Arch Pharmacol. J. Neurochem. Mol Pharmacol, vol.3336869, issue.64, pp.400-51026, 1986.

R. Snider, C. Forray, M. Pfenning, E. Richelson, R. Steinberg et al., Neurotensin stimulates inositol phospholipid metabolism and calcium mobilization in murine neuroblastoma clone N1E-115 SR 48692, a non-peptide neurotensin receptor antagonist differentially affects neurotensin-induced behaviour and changes in dopaminergic transmission, Masu M, Nakanishi S. Structure and functional expression of the cloned rat neurotensin receptor, pp.1214-8921, 1986.

S. Terrillon and M. Bouvier, Receptor-activity-independent recruitment of ?arrestin-2 reveals specific signaling modes, The EMBO J, vol.23, pp.3850-61, 2004.

N. Vita, P. Laurent, S. Lefort, P. Chalon, X. Dumont et al., Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor, FEBS Letters, vol.140, issue.1-2, pp.139-181, 1993.
DOI : 10.1016/0014-5793(93)81509-X

H. Wang and T. Wu, mediates neurotensin excitation of substantia nigra dopaminergic neurons, Molecular Brain Research, vol.36, issue.1, pp.29-36, 1996.
DOI : 10.1016/0169-328X(95)00235-K

M. Yamada, M. Yamada, A. Lombet, P. Forgez, and W. Rostene, Distinct functional characteristics of levocabastine sensitive rat neurotensin NT2 receptor expressed in Chinese hamster ovary cells, Life Sciences, vol.62, issue.23, pp.375-80, 1998.
DOI : 10.1016/S0024-3205(98)00192-1

M. Yamada, M. Yamada, M. Watson, and E. Richelson, Neurotensin stimulates cyclic AMP formation in CHO-rNTR-10 cells expressing the cloned rat neurotensin receptor, European Journal of Pharmacology: Molecular Pharmacology, vol.244, issue.1, pp.99-101, 1993.
DOI : 10.1016/0922-4106(93)90064-G

M. Yamada, M. Yamada, M. Watson, and R. , Deletion mutation in the putative third intracellular loop of the rat neurotensin receptor abolishes polyphosphoinositide hydrolysis but not cyclic AMP formation in CHO-K1 cells

R. Yamauchi, S. Sonoda, Y. Jinsmaa, and M. Yoshikawa, Antinociception induced by ??-lactotensin, a neurotensin agonist peptide derived from ??-lactoglobulin, is mediated by NT2 and D1 receptors, Life Sciences, vol.73, issue.15, pp.1917-1940, 2003.
DOI : 10.1016/S0024-3205(03)00546-0