Maintenance of red blood cell integrity by AMP-activated protein kinase alpha1 catalytic subunit.

Abstract : AMP-activated protein kinase (AMPK) plays a pivotal role in regulating cellular energy metabolism. We previously showed that AMPKalpha1-/- mice develop moderate anemia associated with splenomegaly and high reticulocytosis. Here, we report that splenectomy of AMPKalpha1-/- mice worsened anemia supporting evidence that AMPKalpha1-/- mice developed a compensatory response through extramedullary erythropoiesis in the spleen. Transplantation of bone marrow from AMPKalpha1-/- mice into wild-type recipients recapitulated the hematologic phenotype. Further, AMPKalpha1-/- red blood cells (RBC) showed less deformability in response to shear stress limiting their membrane flexibility. Thus, our results highlight the crucial role of AMPK to preserve RBC integrity.
Type de document :
Article dans une revue
FEBS Letters, Wiley, 2010, 584 (16), pp.3667-71. 〈10.1016/j.febslet.2010.07.041〉
Liste complète des métadonnées

Littérature citée [8 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00514852
Contributeur : Benoit Viollet <>
Soumis le : vendredi 3 septembre 2010 - 14:14:48
Dernière modification le : mercredi 25 juillet 2018 - 10:52:02
Document(s) archivé(s) le : samedi 4 décembre 2010 - 02:50:03

Fichiers

ms_RBC_alpha1_FEBSLett_HAL.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Marc Foretz, Soizic Guihard, Jocelyne Leclerc, Véronique Fauveau, Jean-Pierre Couty, et al.. Maintenance of red blood cell integrity by AMP-activated protein kinase alpha1 catalytic subunit.. FEBS Letters, Wiley, 2010, 584 (16), pp.3667-71. 〈10.1016/j.febslet.2010.07.041〉. 〈inserm-00514852〉

Partager

Métriques

Consultations de la notice

332

Téléchargements de fichiers

390