Synthesis and antioxidant activity evaluation of a syringic hydrazones family.

Abstract : A novel series of hydrazones derived from syringaldehyde and their antioxidant properties have been explored. Several employed methods such as scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS(+)) radical cation expressed as Trolox equivalent antioxidant capacity (TEAC), inhibition of superoxide anion (O(2)(-)) generation and of human cell-mediated low-density lipoprotein oxidation (monitored by the formation of TBARS) exhibited their potent antioxidant properties. The carbonyl scavenger efficacy was also evaluated by measuring the ability to decrease the protein carbonyl content in cells challenged with oxidized LDL. In this report, we discuss about the synthesis of hydrazones and their dual biological role, antioxidant and carbonyl scavenger for further application in atherosclerosis.
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European Journal of Medicinal Chemistry, Elsevier, 2010, 45 (7), pp.3019-26. 〈10.1016/j.ejmech.2010.03.031〉
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http://www.hal.inserm.fr/inserm-00504802
Contributeur : Marie Francoise Simon <>
Soumis le : mercredi 21 juillet 2010 - 15:04:12
Dernière modification le : jeudi 11 janvier 2018 - 06:15:23

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Nadji Belkheiri, Benaissa Bouguerne, Florence Bedos-Belval, Hubert Duran, Corinne Bernis, et al.. Synthesis and antioxidant activity evaluation of a syringic hydrazones family.. European Journal of Medicinal Chemistry, Elsevier, 2010, 45 (7), pp.3019-26. 〈10.1016/j.ejmech.2010.03.031〉. 〈inserm-00504802〉

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