FAN (factor associated with neutral sphingomyelinase activation), a moonlighting protein in TNF-R1 signaling.

Abstract : TNF-alpha is a pleiotropic cytokine involved in the regulation of various biological effects, including cell survival and proliferation, cell differentiation, and cell death. Moreover, TNF-alpha triggers proinflammatory responses, essentially through its ability to promote the expression of various proinflammatory genes. Most of the biological effects initiated by TNF-alpha rely on its ability to bind to and activate TNF-R1. As a consequence, molecular complexes are being formed, resulting from the recruitment of multiple adaptor proteins to the intracellular TNF-R1 DD. The adaptor protein FAN constitutively binds to a proximal membrane domain of TNF-R1 called NSD. Herein, the role of FAN in TNF-alpha-induced cell signaling and biological responses is discussed.
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Article dans une revue
Journal of Leukocyte Biology, Society for Leukocyte Biology, 2010, epub ahead of print. 〈10.1189/jlb.0410188〉
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Contributeur : Marie Francoise Simon <>
Soumis le : mercredi 21 juillet 2010 - 11:44:36
Dernière modification le : jeudi 22 juillet 2010 - 11:20:59

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Anne Montfort, Pascal Martin, Thierry Levade, Hervé Benoist, Bruno Ségui. FAN (factor associated with neutral sphingomyelinase activation), a moonlighting protein in TNF-R1 signaling.. Journal of Leukocyte Biology, Society for Leukocyte Biology, 2010, epub ahead of print. 〈10.1189/jlb.0410188〉. 〈inserm-00504725〉

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