Maternal fine particulate matter exposure, polymorphism in xenobiotic-metabolizing genes and offspring birth weight. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Reproductive Toxicology Année : 2010

Maternal fine particulate matter exposure, polymorphism in xenobiotic-metabolizing genes and offspring birth weight.

Résumé

We aimed to describe if polymorphisms in xenobiotics-metabolizing genes modify the effect of maternal exposure to fine particulate matter (PM(2.5)) on offspring birth weight. Among newborns from LISA cohort, we tested if polymorphisms of GSTT1, GSTP1, GSTM1, and CYP2D6 genes modified the effect measure of PM(2.5) on term birth weight. Subsequently, we tested if polymorphisms modified the effect of other exposure factors with possibly similar pathways of action (active or passive smoking). PM (2.5) exposure above the median value (reference, below) was associated with birth weight changes by 76 g in the homozygous wild type genotype (n=161), -90 g in the heterozygous genotype (n=154) and -168 g in children with GSTP1 *1B/*1B mutant genotype (n=39, interaction test, p=0.05). No effect measure modification with PM(2.5) was detected for GSTT1, GSTM1 or CYP2D6 polymorphisms (p≥ 0.12). No effect measure modification with GSTP1 polymorphism was detected for active (p=0.71) nor for passive smoking effects on birth weight (p=0.13).
Fichier principal
Vignette du fichier
PM25_genes_and_birth_weight_in_LISA-Reprod_Toxicol-submitted-2010_02_25.pdf (1.82 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

inserm-00503997 , version 1 (04-04-2011)

Identifiants

Citer

Rémy Slama, Carolin Gräbsch, Johanna Lepeule, Valérie Siroux, Josef Cyrys, et al.. Maternal fine particulate matter exposure, polymorphism in xenobiotic-metabolizing genes and offspring birth weight.: Air pollution, genes and birthweight. Reproductive Toxicology, 2010, 30 (4), pp.600-12. ⟨10.1016/j.reprotox.2010.07.001⟩. ⟨inserm-00503997⟩

Collections

INSERM UGA U823
704 Consultations
1245 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More