Cystic fibrosis transmembrane conductance regulator (CFTR) regulates the production of osteoprotegerin (OPG) and prostaglandin (PG) E2 in human bone.

Abstract : Bone loss is an important clinical issue in patients with cystic fibrosis (CF). Whether the cystic fibrosis transmembrane conductance regulator (CFTR) plays a direct role in bone cell function is yet unknown. In this study, we provide evidence that inhibition of CFTR-Cl(-) channel function results in a significant decrease of osteoprotegerin (OPG) secretion accompanied with a concomitant increase of prostaglandin (PG) E(2) secretion of primary human osteoblast cultures (n=5). Our data therefore suggest that in bone cells of CF patients, the loss of CFTR activity may result in an increased inflammation-driven bone resorption (through both the reduced OPG and increased PGE(2) production), and thus might contribute to the early bone loss reported in young children with CF.
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http://www.hal.inserm.fr/inserm-00501818
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Soumis le : lundi 12 juillet 2010 - 16:14:40
Dernière modification le : jeudi 11 janvier 2018 - 06:21:21
Document(s) archivé(s) le : jeudi 1 décembre 2016 - 10:03:43

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Louis Le Heron, Christine Guillaume, Frédéric Velard, Julien Braux, Lhousseine Touqui, et al.. Cystic fibrosis transmembrane conductance regulator (CFTR) regulates the production of osteoprotegerin (OPG) and prostaglandin (PG) E2 in human bone.. Journal of Cystic Fibrosis, Elsevier, 2010, 9 (1), pp.69-72. 〈10.1016/j.jcf.2009.11.005〉. 〈inserm-00501818〉

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