Polycyclic aromatic hydrocarbons potentiate high-fat diet effects on intestinal inflammation.

Abstract : We demonstrate that intestinal inflammation caused by high-fat diet is increased by the environmental contaminant benzo[a]pyrene. Our in vivo results indicate that a high-fat diet (HFD) induces a pre-diabetic state in mice compared with animals fed normal chow. HFD increased IL-1betamRNA concentration in the jejunum, colon, and liver, and TNFalpha was increased in the colon and strongly increased in the liver. HFD also increased the expression of other genes related to type 2 diabetes, such as the uncoupling protein UCP2, throughout the bowel and liver, but not in the colon. The treatment of HFD with BaP enhanced the expression of IL-1beta in the liver and TNFalpha throughout the bowel and in the liver. Adding BaP to the diet also caused a significant decrease in the expression of the incretin glucagon-like peptide 1, which plays an important role in insulin secretion. Our results suggest that intestinal inflammation may be involved in the onset of type 2 diabetes and that chronic exposure to environmental polycyclic aromatic hydrocarbons can increase the risk of type 2 diabetes by inducing pro-inflammatory cytokine production.
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Toxicology Letters, Elsevier, 2010, 196 (3), pp.161-7. 〈10.1016/j.toxlet.2010.04.010〉
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Soumis le : mardi 15 juin 2010 - 15:41:43
Dernière modification le : jeudi 18 janvier 2018 - 02:00:50

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Ayman Khalil, Pierre-Henri Villard, Mai Anh Dao, Rémy Burcelin, Serge Champion, et al.. Polycyclic aromatic hydrocarbons potentiate high-fat diet effects on intestinal inflammation.. Toxicology Letters, Elsevier, 2010, 196 (3), pp.161-7. 〈10.1016/j.toxlet.2010.04.010〉. 〈inserm-00492275〉

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