M. Morille, C. Passirani, A. Vonarbourg, A. Clavreul, and J. P. Benoit, Progress in developing cationic vectors for non-viral systemic gene therapy against cancer, Biomaterials, vol.29, issue.24-25, pp.3477-96, 2008.
DOI : 10.1016/j.biomaterials.2008.04.036

URL : https://hal.archives-ouvertes.fr/inserm-00353462

D. C. Drummond, C. O. Noble, M. E. Hayes, J. W. Park, and D. B. Kirpotin, Pharmacokinetics and in vivo drug release rates in liposomal nanocarrier development, Journal of Pharmaceutical Sciences, vol.97, issue.11, pp.4696-740, 2008.
DOI : 10.1002/jps.21358

S. M. Moghimi, A. C. Hunter, and J. C. Murray, Long-circulating and target-specific nanoparticles: theory to practice, Pharmacol Rev, vol.53, pp.283-318, 2001.

C. Passiraniand and J. P. Benoit, Complement activation by injectable colloidal drug carriers, Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids, pp.187-230, 2005.

H. J. Muller-eberhard, Molecular Organization and Function of the Complement System, Annual Review of Biochemistry, vol.57, issue.1, pp.321-343, 1988.
DOI : 10.1146/annurev.bi.57.070188.001541

M. Mayer, Complement and Complement fixation Experimental immunochemistry; énd edn, pp.133-156, 1961.

A. L. Klibanov, K. Maruyama, V. P. Torchilin, and L. Huang, Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes, FEBS Letters, vol.3, issue.1, pp.235-242, 1990.
DOI : 10.1016/0014-5793(90)81016-H

T. M. Allenand and A. Chonn, Large unilamellar liposomes with low uptake into the reticuloendothelial system, FEBS Letters, vol.557, issue.1, pp.42-48, 1987.
DOI : 10.1016/0014-5793(87)80506-9

A. Gabizon, R. Isacson, E. Libson, B. Kaufman, B. Uziely et al., Clinical Studies of Liposome-Encapsulated Doxorubicin, Acta Oncologica, vol.100, issue.7, pp.779-786, 1994.
DOI : 10.1073/pnas.85.18.6949

H. Maeda, J. Wu, T. Sawa, Y. Matsumura, and K. Hori, Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review, Journal of Controlled Release, vol.65, issue.1-2, pp.271-84, 2000.
DOI : 10.1016/S0168-3659(99)00248-5

Y. Matsumuraand and H. Maeda, A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs, Cancer Res, vol.46, pp.6387-92, 1986.

A. Vonarbourg, C. Passirani, P. Saulnier, P. Simard, J. C. Leroux et al., Evaluation of pegylated lipid nanocapsules versus complement system activation and macrophage uptake, Journal of Biomedical Materials Research Part A, vol.21, issue.3, pp.620-628, 2006.
DOI : 10.1002/jbm.a.30711

Y. Jallouli, A. Paillard, J. Chang, E. Sevin, and D. Betbeder, Influence of surface charge and inner composition of porous nanoparticles to cross blood???brain barrier in vitro, International Journal of Pharmaceutics, vol.344, issue.1-2, pp.103-112, 2007.
DOI : 10.1016/j.ijpharm.2007.06.023

P. M. Loiseau, L. Imbertie, C. Bories, D. Betbeder, and I. Miguel, Design and Antileishmanial Activity of Amphotericin B-Loaded Stable Ionic Amphiphile Biovector Formulations, Antimicrobial Agents and Chemotherapy, vol.46, issue.5, pp.1597-601, 2002.
DOI : 10.1128/AAC.46.5.1597-1601.2002

A. Debin, R. Kravtzoff, J. V. Santiago, L. Cazales, S. Sperandio et al., Intranasal immunization with recombinant antigens associated with new cationic particles induces strong mucosal as well as systemic antibody and CTL responses, Vaccine, vol.20, issue.21-22, pp.2752-63, 2002.
DOI : 10.1016/S0264-410X(02)00191-3

S. El-mir, A. Casanova, D. Betbeder, and F. Triebel, A combination of interleukin-2 and 60 nm cationic supramolecular biovectors for the treatment of established tumours by subcutaneous or intranasal administration, European Journal of Cancer, vol.37, issue.8, pp.1053-60, 2001.
DOI : 10.1016/S0959-8049(01)00084-3

B. C. Baudner, O. Balland, M. M. Giuliani, P. Von-hoegen, R. Rappuoli et al., Enhancement of Protective Efficacy following Intranasal Immunization with Vaccine Plus a Nontoxic LTK63 Mutant Delivered with Nanoparticles, Infection and Immunity, vol.70, issue.9, pp.4785-90, 2002.
DOI : 10.1128/IAI.70.9.4785-4790.2002

D. Betbeder, S. Sperandio, J. P. Latapie, J. De-nadai, A. Etienne et al., Biovector nanoparticles improve antinociceptive efficacy of nasal morphine, Pharmaceutical Research, vol.17, issue.6, pp.743-751, 2000.
DOI : 10.1023/A:1007594602449

A. Razafindratsita, N. Saint-lu, L. Mascarell, N. Berjont, T. Bardon et al., Improvement of sublingual immunotherapy efficacy with a mucoadhesive allergen formulation, Journal of Allergy and Clinical Immunology, vol.120, issue.2, pp.278-85, 2007.
DOI : 10.1016/j.jaci.2007.04.009

L. Fenart, A. Casanova, B. Dehouck, C. Duhem, S. Slupek et al., Evaluation of effect of charge and lipid coating on ability of 60-nm nanoparticles to cross an in vitro model of the blood-brain barrier, J Pharmacol Exp Ther, vol.291, pp.1017-1039, 1999.
URL : https://hal.archives-ouvertes.fr/hal-00534808

M. Major, E. Prieur, J. F. Tocanne, D. Betbeder, and A. M. Sautereau, Characterisation and phase behaviour of phospholipid bilayers adsorbed on spherical polysaccharidic nanoparticles, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1327, issue.1, pp.32-40, 1997.
DOI : 10.1016/S0005-2736(97)00041-2

M. C. Woodleand and D. Papahadjopoulos, [9] Liposome preparation and size characterization, Methods Enzymol, vol.171, pp.193-217, 1989.
DOI : 10.1016/S0076-6879(89)71012-0

J. P. Siguier, M. Major, and O. Balland, Development of a new method to characterize (SMBV???) antigen formulations using surface plasmon resonance technology, International Journal of Pharmaceutics, vol.242, issue.1-2, pp.411-416, 2002.
DOI : 10.1016/S0378-5173(02)00227-2

M. M. Domingues, P. S. Santiago, M. A. Castanho, and N. C. Santos, What can light scattering spectroscopy do for membrane-active peptide studies?, Journal of Peptide Science, vol.107, issue.4, pp.394-400, 2008.
DOI : 10.1002/psc.1007

E. Serefoglou, J. Oberdisse, and G. Staikos, Characterization of the Soluble Nanoparticles Formed through Coulombic Interaction of Bovine Serum Albumin with Anionic Graft Copolymers at Low pH, Biomacromolecules, vol.8, issue.4, pp.1195-1199, 2007.
DOI : 10.1021/bm061094t

URL : https://hal.archives-ouvertes.fr/hal-00149285

H. Ohshima, Electrokinetics of soft particles, Colloid and Polymer Science, vol.21, issue.80, pp.1411-1421, 2007.
DOI : 10.1007/s00396-007-1740-7

A. Vonarbourg, P. Saulnier, C. Passirani, and J. P. Benoit, Electrokinetic properties of noncharged lipid nanocapsules: Influence of the dipolar distribution at the interface, ELECTROPHORESIS, vol.15, issue.11, pp.2066-75, 2005.
DOI : 10.1002/elps.200410145

K. Matsuzaki, M. Harada, S. Funakoshi, N. Fujii, and K. Miyajima, Physicochemical determinants for the interactions of magainins 1 and 2 with acidic lipid bilayers, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1063, issue.1, pp.162-70, 1991.
DOI : 10.1016/0005-2736(91)90366-G

I. De-miguel, L. Imbertie, V. Rieumajou, M. Major, R. Kravtzoff et al., Proofs of the structure of lipid coated nanoparticles (SMBV) used as drug carriers, Pharmaceutical Research, vol.17, issue.7, pp.817-841, 2000.
DOI : 10.1023/A:1007504124603

H. Ohshima, Electrophoretic Mobility of Soft Particles, Journal of Colloid and Interface Science, vol.163, issue.2, pp.474-483, 1994.
DOI : 10.1006/jcis.1994.1126

V. Ducel, P. Saulnier, J. Richard, and F. Boury, Plant protein???polysaccharide interactions in solutions: application of soft particle analysis and light scattering measurements, Colloids and Surfaces B: Biointerfaces, vol.41, issue.2-3, pp.95-102, 2005.
DOI : 10.1016/j.colsurfb.2004.10.031

K. Makino, N. Yamamoto, K. Higuchi, N. Harada, H. Ohshima et al., Phagocytic uptake of polystyrene microspheres by alveolar macrophages: effects of the size and surface properties of the microspheres, Colloids and Surfaces B: Biointerfaces, vol.27, issue.1, pp.33-39, 2003.
DOI : 10.1016/S0927-7765(02)00042-5

K. Makino, M. Umetsu, Y. Goto, A. Nakayama, T. Suhara et al., Interaction between charged soft microcapsules and red blood cells: effects of PEGylation of microcapsule membranes upon their surface properties, Colloids and Surfaces B: Biointerfaces, vol.13, issue.6, pp.287-297, 1999.
DOI : 10.1016/S0927-7765(99)00041-7

A. Beduneau, P. Saulnier, N. Anton, F. Hindre, C. Passirani et al., Pegylated Nanocapsules Produced by an Organic Solvent-Free Method: Evaluation of their Stealth Properties, Pharmaceutical Research, vol.134, issue.109, pp.2190-2199, 2006.
DOI : 10.1007/s11095-006-9061-y

D. Labarre, B. Montdargent, M. Carreno, and F. Maillet, Strategy forin vitro evaluation of the interactions between biomaterials and complement system, Journal of Applied Biomaterials, vol.9, issue.3, pp.231-240, 1993.
DOI : 10.1002/jab.770040304

C. Passirani, G. Barratt, J. P. Devissaguet, and D. Labarre, Long-circulating nanoparticles bearing heparin or dextran covalently bound to poly(methyl methacrylate), Pharmaceutical Research, vol.15, issue.7, pp.1046-50, 1998.
DOI : 10.1023/A:1011930127562

M. Roser, D. Fischer, and T. Kissel, Surface-modified biodegradable albumin nano- and microspheres. II: effect of surface charges on in vitro phagocytosis and biodistribution in rats, European Journal of Pharmaceutics and Biopharmaceutics, vol.46, issue.3, pp.255-63, 1998.
DOI : 10.1016/S0939-6411(98)00038-1

A. Vonarbourg, C. Passirani, P. Saulnier, and J. P. Benoit, Parameters influencing the stealthiness of colloidal drug delivery systems, Biomaterials, vol.27, issue.24, pp.4356-73, 2006.
DOI : 10.1016/j.biomaterials.2006.03.039

C. D. Blackand and G. Gregoriadis, Interaction of liposomes with blood plasma proteins, Biochem Soc Trans, vol.4, pp.253-259, 1976.

J. Toufikand and D. Labarre, Relationship between reduction of complement activation by polysaccharide surfaces bearing diethylaminoethyl groups and their degree of substitution, Biomaterials, vol.16, issue.14, pp.1081-1089, 1995.
DOI : 10.1016/0142-9612(95)98904-S

M. P. Carreno, D. Labarre, M. Jozefowicz, and M. D. Kazatchkine, The ability of sephadex to activate human complement is suppressed in specifically substituted functional sephadex derivatives, Molecular Immunology, vol.25, issue.2, pp.165-71, 1988.
DOI : 10.1016/0161-5890(88)90064-8

S. K. Law, T. M. Minich, and R. P. Levine, Binding reaction between the third human complement protein and small molecules, Biochemistry, vol.20, issue.26, pp.7457-63, 1981.
DOI : 10.1021/bi00529a020

D. Labarre, A. Laurent, A. Lautier, S. Bouhni, L. Kerbellec et al., Complement activation by substituted polyacrylamide hydrogels for embolisation and implantation, Biomaterials, vol.23, issue.11, pp.2319-2346, 2002.
DOI : 10.1016/S0142-9612(01)00366-0

D. E. Owens and N. A. Peppas, Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles, International Journal of Pharmaceutics, vol.307, issue.1, pp.93-102, 2006.
DOI : 10.1016/j.ijpharm.2005.10.010

A. Gabizonand and D. Papahadjopoulos, The role of surface charge and hydrophilic groups on liposome clearance in vivo, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1103, issue.1, pp.94-100, 1992.
DOI : 10.1016/0005-2736(92)90061-P

C. L. Villiers, M. B. Villiers, and P. N. Marche, [Role of the complement C3 protein in the control of the specific immune response], Ann Biol Clin, vol.57, pp.127-162, 1999.

C. Jérôme and . Jérôme, PEO coated magnetic nanoparticles for biomedical application, European Polymer Journal, vol.44, pp.3191-3199, 2008.

C. Jérôme and . Jérôme, pH-Responsive Flower-Type Micelles Formed by a Biotinylated Poly(2-vinylpyridine)-block-poly(ethylene oxide)-block-poly(?caprolactone ) Triblock Copolymer, Advanced Functional Materials, vol.19, pp.1416-1425, 2009.

C. Jerome and . Jerome, Synthesis and pH-dependent micellization of diblock copolymer mixtures, J Colloid Interface Sci, vol.329, pp.235-278, 2009.
URL : https://hal.archives-ouvertes.fr/inserm-00343572

A. Layre, P. Couvreur, H. Chacun, J. Richard, C. Passirani et al., Novel composite core-shell nanoparticles as busulfan carriers, Journal of Controlled Release, vol.111, issue.3, pp.271-80, 2006.
DOI : 10.1016/j.jconrel.2006.01.002

J. Rieger, C. Passirani, J. Benoit, K. Van-butsele, R. Jérôme et al., Synthesis of Amphiphilic Copolymers of Poly(ethylene oxide) and Poly(??-caprolactone) with Different Architectures, and Their Role in the Preparation of Stealthy Nanoparticles, Advanced Functional Materials, vol.98, issue.11, pp.1506-1514, 2006.
DOI : 10.1002/adfm.200500110