B. J. Albala, S. L. Moshe, and R. Okada, Kainic-acid-induced seizures: A developmental study, Developmental Brain Research, vol.13, issue.1, pp.139-148, 1984.
DOI : 10.1016/0165-3806(84)90085-3

Y. Ben-ari, Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy, Neuroscience, vol.14, issue.2, pp.14-375, 1985.
DOI : 10.1016/0306-4522(85)90299-4

Y. Ben-ari, E. Cherubini, R. Corradetti, and J. L. Gaiarsa, Giant synaptic potentials in immature rat CA3 hippocampal neurones., The Journal of Physiology, vol.416, issue.1, pp.416-303, 1989.
DOI : 10.1113/jphysiol.1989.sp017762

Y. Ben-ari, R. Khazipov, X. Leinekugel, O. Caillard, and J. L. Gaiarsa, GABAA, NMDA and AMPA receptors: a developmentally regulated 'm??nage ?? trois', Trends in Neurosciences, vol.20, issue.11, pp.523-529, 1997.
DOI : 10.1016/S0166-2236(97)01147-8

M. S. Berry and V. W. Penthreath, Criteria for distinguishing between monosynaptic and polysynaptic transmission, Brain Research, vol.105, issue.1, pp.1-20, 1976.
DOI : 10.1016/0006-8993(76)90919-7

A. Bragin, J. Csicsvari, M. Penttonen, and G. Buzsaki, Epileptic afterdischarge in the hippocampal???entorhinal system: current source density and unit studies, Neuroscience, vol.76, issue.4, pp.76-1187, 1997.
DOI : 10.1016/S0306-4522(96)00446-0

G. Buzsaki and J. J. Chrobak, Temporal structure in spatially organized neuronal ensembles: a role for interneuronal networks, Current Opinion in Neurobiology, vol.5, issue.4, pp.504-510, 1995.
DOI : 10.1016/0959-4388(95)80012-3

P. E. Castillo, R. C. Malenka, and R. A. Nicoll, Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons, Nature, vol.388, pp.182-186, 1997.

E. Cherubini, M. R. De-feo, O. Mecarelli, and G. F. Ricci, Behavioral and electrographic patterns induced by systemic administration of kainic acid in developing rats, Developmental Brain Research, vol.9, issue.1, pp.69-77, 1983.
DOI : 10.1016/0165-3806(83)90110-4

M. Constantine-paton, H. T. Cline, and E. Debski, Patterned Activity, Synaptic Convergence, and the NMDA Receptor in Developing Visual Pathways, Annual Review of Neuroscience, vol.13, issue.1, pp.129-154, 1990.
DOI : 10.1146/annurev.ne.13.030190.001021

F. Dessi, A. Respera, and Y. Ben-ari, Effects of neonatal gamma-ray irradiation on rat hippocampus. II. Development of excitatory amino acid binding sites, Neuroscience, pp.42-151, 1991.

M. B. Feller, D. P. Wellis, D. Stellwagen, F. S. Werblin, and C. J. Shatz, Requirement for Cholinergic Synaptic Transmission in the Propagation of Spontaneous Retinal Waves, Science, vol.272, issue.5265, pp.1182-1187, 1996.
DOI : 10.1126/science.272.5265.1182

R. S. Fisher and B. E. Alger, Elecrophysiological mechanisms of kainic acid-induced epileptiform activity in the rat hippocampal slice, J. Neurosci, vol.4, 1984.

A. C. Foster, E. E. Mena, D. T. Monaghan, and C. W. Cotman, Synaptic localization of kainic acid binding sites, Nature, vol.31, issue.5793, pp.73-75, 1981.
DOI : 10.1038/289073a0

M. Frerking, R. C. Malenka, and R. Nicol, Synaptic activation of kainate receptors on hippocampal interneurons, Nature Neuroscience, vol.1, issue.6, pp.479-486, 1998.
DOI : 10.1038/2194

J. L. Gaiarsa, M. Beaudoin, and Y. Ben-ari, Effect of neonatal degranulation on the morphological development of rat CA3 pyramidal neurons: Inductive role of mossy fibers on the formation of thorny excrescences, The Journal of Comparative Neurology, vol.179, issue.4, pp.612-625, 1992.
DOI : 10.1002/cne.903210408

J. L. Gaiarsa, L. Zagrean, and Y. Ben-ari, Neonatal irradiation prevents the formation of hippocampal mossy ®bers and the epileptic action of kainate on rat CA3 pyramidal neurons, J. Neurophysiol, vol.71, pp.204-215, 1994.

C. S. Goodman and C. J. Shatz, Developmental mechanisms that generate precise patterns of neuronal connectivity, Cell, vol.72, issue.10, pp.77-98, 1993.
DOI : 10.1016/S0092-8674(05)80030-3

W. A. Hauser, Epidemiology of epilepsy in children, Cleveland Clinic Journal of Medicine, vol.56, issue.Supplement, pp.419-429, 1995.
DOI : 10.3949/ccjm.56.s1.185

U. Heinemann, H. D. Lux, and M. J. Gutnick, Extracellular free calcium Seizure in rat neonatal limbic system in vitro 3479, 1977.

G. Holmes, Epilepsy in the Developing Brain: Lessons from the Laboratory and Clinic, Epilepsia, vol.14, issue.1, pp.38-50, 1997.
DOI : 10.1002/ana.410360314

G. L. Holmes and Y. Ben-ari, Seizures in the Developing Brain, Neuron, vol.21, issue.6, pp.1231-1234, 1998.
DOI : 10.1016/S0896-6273(00)80642-X

G. L. Holmes, J. L. Gaiarsa, N. Chevassus-au-louis, Y. Yang, and Y. Ben-ari, Consequences of neonatal seizures in the rat: Morphological and behavioral effects, Annals of Neurology, vol.97, issue.6, pp.845-857, 1998.
DOI : 10.1002/ana.410440602

J. G. Jefferys, Nonsynaptic modulation of neuronal activity in the brain: electric currents and extracellular ions, Physiol. Rev, vol.75, pp.689-723, 1995.

I. Khalilov, M. Esclapez, R. Khazipov, D. Aggoun, K. Lamsa et al., A Novel In Vitro Preparation: the Intact Hippocampal Formation, Neuron, vol.19, issue.4, pp.743-749, 1997.
DOI : 10.1016/S0896-6273(00)80956-3

URL : https://hal.archives-ouvertes.fr/inserm-00522462

I. Khalilov, R. Khazipov, M. Esclapez, and Y. Ben-ari, Bicuculline induces ictal-like seizures in the intact rat hippocampus in vitro, Eur. J. Pharmacol, vol.38, pp.11-13, 1997.

R. Khazipov, L. Desfreres, I. Khalilov, and Y. Ben-ari, A three compartment independent chamber to study commissural synapses in vitro, J. Neurophysiol, vol.81, pp.921-924, 1999.

R. Khazipov, X. Leinekugel, I. Khalilov, J. L. Gaiarsa, and Y. Ben-ari, Synchronization of GABAergic interneuronal network in CA3 sub®eld of neonatal rat hippocampal slices, J. Physiol, pp.498-763, 1997.

H. Komuro and P. Rakic, Intracellular Ca 2+ ¯uctuations modulate the rate of neuronal migration, Neuron, pp.17-275, 1996.

X. Leinekugel, I. Khalilov, Y. Ben-ari, and R. Khazipov, Giant depolarising potentials: the septal pole of hippocampus paces the activity of the intact neonatal septo-hippocampal complex in vitro, J. Neurosci, vol.18, pp.6349-6357, 1998.

X. Leinekugel, V. Tseeb, Y. Ben-ari, and P. Bregestovski, Synaptic GABA-A activation induces Ca ++ rise in pyramidal cells and interneurons from rat neonatal hippocampal slices, J. Physiol, pp.487-319, 1995.

R. Linke, T. Pabst, and M. Frotscher, Development of the hippocamposeptal projection in the rat, The Journal of Comparative Neurology, vol.1, issue.4, pp.602-616, 1995.
DOI : 10.1002/cne.903510409

J. J. Loturco, D. F. Owens, M. J. Heath, M. B. Davis, and A. R. Kriegstein, GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis, Neuron, vol.15, issue.6, pp.1287-1298, 1995.
DOI : 10.1016/0896-6273(95)90008-X

H. Matsumoto and C. Ajmone-marsan, Cortical cellular phenomena in experimental epilepsy: Ictal manifestations, Experimental Neurology, vol.9, issue.4, pp.305-326, 1964.
DOI : 10.1016/0014-4886(64)90026-3

D. A. Mccormick and T. Bal, SLEEP AND AROUSAL: Thalamocortical Mechanisms, Annual Review of Neuroscience, vol.20, issue.1, pp.185-215, 1997.
DOI : 10.1146/annurev.neuro.20.1.185

R. Miles and R. K. Wong, Excitatory synaptic interactions between CA3 neurons in the guinea-pig hippocampus, J. Physiol, pp.373-397, 1986.

M. A. Mitaki, G. L. Holmes, A. Chronopoulos, P. Hyde, S. Thurber et al., Phenobarbital modi®es seizure-related brain injury in the developing brain, Ann. Neurol, vol.36, pp.425-433, 1994.

S. Moshe and M. Cornblath, Developmental aspects of epileptogenesis The Treatment of Epilepsy: Principles and Practice, Lea & Febiger, pp.99-110, 1993.

C. Mulle, A. Sailer, I. Perez-otano, H. Dickinson-anson, P. E. Castillo et al., Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-de®cient mice, Nature, vol.392, pp.601-605, 1998.

J. V. Nadler, Kainic acid: Neurophysiological and neurotoxic actions, Life Sciences, vol.24, issue.4, pp.289-299, 1979.
DOI : 10.1016/0024-3205(79)90325-4

J. V. Nadler, Kainic acid as a tool for the study of temporal lobe epilepsy, Life Sci, vol.29, 1981.

L. Nitecka, E. Tremblay, G. Charton, J. P. Bouillot, M. L. Berger et al., Maturation of kainic acid seizure-brain damage syndrome in the rat. II. Histopathological sequelae, Neuroscience, vol.13, issue.4, pp.1073-1094, 1984.
DOI : 10.1016/0306-4522(84)90289-6

T. Popovici, A. Represa, V. Crepel, G. Barbin, M. Beaudoin et al., Effects of kainic acid-induced seizures and ischemia on c-fos-like proteins in rat brain, Brain Research, vol.536, issue.1-2, pp.183-194, 1990.
DOI : 10.1016/0006-8993(90)90024-6

A. Represa, E. Tremblay, and Y. Ben-ari, Kainate binding sites in the hippocampal mossy fibers: Localization and plasticity, Neuroscience, vol.20, issue.3, pp.739-748, 1987.
DOI : 10.1016/0306-4522(87)90237-5

P. A. Rutecki, F. J. Lebeda, and D. Johnston, Epileptiform activity induced by changes in extracellular potassium in hippocampus, J. Neurophysiol, vol.54, pp.1363-1374, 1985.

S. Sawada, M. Higashima, and C. Yamamoto, Kainic acid induces long-lasting depolarizations in hippocampal neurons only when applied to stratum lucidum, Experimental Brain Research, vol.24, issue.1, pp.135-140, 1988.
DOI : 10.1007/BF00248508

K. L. Smith, D. H. Szarowski, J. N. Turner, and J. W. Swann, Diverse populations of neurons mediated by local circuit excitation in developing hippocampus, J. Neurophysiol, vol.74, pp.650-672, 1995.

C. E. Stafstrom, J. L. Thompson, and G. L. Holmes, Kainic acid seizures in the developing brain: status epilepticus and spontaneous recurrent seizures, Developmental Brain Research, vol.65, issue.2, pp.227-236, 1992.
DOI : 10.1016/0165-3806(92)90184-X

M. Steriade, Corticothalamic networks, oscillations, and plasticity, Adv. Neurol, vol.77, pp.105-134, 1998.

H. Super and E. Soriano, The organization of the embronic and early postnatal murine hippocampus. II. Development of entorhinal, commissural, and septal connections studied with the lipophilic tracer DiI, Journal of Comparative Neurology, vol.179, issue.3, pp.101-120, 1994.
DOI : 10.1002/cne.903440108

J. W. Swann, Synaptogenesis and epileptogenesis in developing neuronal networks, pp.195-234, 1995.

J. W. Swann and R. J. Brady, Penicillin-induced epileptogenesis in immature rat CA3 hippocampal pyramidal cells, Developmental Brain Research, vol.12, issue.2, pp.243-254, 1984.
DOI : 10.1016/0165-3806(84)90046-4

J. W. Swann and S. L. Moshe, Developmental issues in animal models, Epilepsy: a Comprehensive Textbook, pp.467-479, 1997.

R. D. Traub, R. Miles, and R. K. Wong, Models of synchronized hippocampal bursts in the presence of inhibition. I. Single population events, J. Neurophysiol, vol.58, pp.739-751, 1987.

E. Tremblay, L. Nitecka, M. L. Berger, and Y. Ben-ari, Maturation of kainic acid seizure-brain damage syndrome in the rat. i. clinical, electrographic and metabolic observations, Neuroscience, vol.13, issue.4, pp.1051-1072, 1984.
DOI : 10.1016/0306-4522(84)90288-4

M. Vignes and G. L. Collingridge, The synaptic activation of kainate receptors, Nature, pp.388-179, 1997.
URL : https://hal.archives-ouvertes.fr/hal-00659452

L. E. White and J. L. Price, The functional anatomy of limbic status epilepticus in the rat. II. The effects of focal deactivation, J. Neurosci, vol.13, pp.4810-4830, 1993.

H. Xie and L. Ziskind-conhaim, Blocking Ca(2+)-dependent synaptic release delays motoneuron differentiation in the rat spinal cord, J. Neurosci, vol.15, pp.5900-5911, 1995.

R. Yuste, D. A. Nelson, W. W. Rubin, and L. C. Katz, Neuronal domains in developing neocortex: Mechanisms of coactivation, Neuron, vol.14, issue.1, pp.7-17, 1995.
DOI : 10.1016/0896-6273(95)90236-8