Theory for epithelial-mesenchymal transformation based on the ?fixed cortex? cell motility model, Cell Motility and the Cytoskeleton, vol.108, issue.4, pp.455-462, 1989. ,
DOI : 10.1002/cm.970140403
Cutaneous wound healing: a partial and reversible EMT. Rise and fall of epithelial phenotype: Concepts of epithelialmesenchymal transition, Landes Biosciences, 2004. ,
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells, Cell, vol.133, issue.4, pp.704-719, 2008. ,
DOI : 10.1016/j.cell.2008.03.027
Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition, PLoS ONE, vol.133, issue.8, p.2888, 2008. ,
DOI : 10.1371/journal.pone.0002888.g005
The epithelial???mesenchymal transition: new insights in signaling, development, and disease, The Journal of Cell Biology, vol.63, issue.7, pp.973-81, 2006. ,
DOI : 10.1038/ncb1173
Epithelial-Mesenchymal Transition, The American Journal of Pathology, vol.174, issue.5, pp.1588-93, 2009. ,
DOI : 10.2353/ajpath.2009.080545
URL : https://hal.archives-ouvertes.fr/inserm-00377343
A causal role for E-cadherin in the transition from adenoma to carcinoma, Nature, vol.10, issue.6672, pp.190-193, 1998. ,
DOI : 10.1038/32433
E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells, The Journal of Cell Biology, vol.113, issue.1, pp.173-85, 1991. ,
DOI : 10.1083/jcb.113.1.173
Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role, Cell, vol.66, issue.1, pp.107-126, 1991. ,
DOI : 10.1016/0092-8674(91)90143-M
Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, vol.1198, issue.1, pp.11-26, 1994. ,
DOI : 10.1016/0304-419X(94)90003-5
The transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulation, Journal of Cell Science, vol.117, issue.9, pp.1675-85, 2004. ,
DOI : 10.1242/jcs.01004
E-cadherin controls beta-catenin and NF-kappaB transcriptional activity in mesenchymal gene expression, J Cell Sci, vol.121, pp.2224-2258, 2008. ,
Mechanisms identified in the transcriptional control of epithelial gene expression, J Biol Chem, vol.271, issue.1, pp.595-602, 1996. ,
[Mechanisms of cell adhesion and migration ,
Recycling of E-Cadherin, The Journal of Cell Biology, vol.95, issue.1, pp.219-251, 1999. ,
DOI : 10.1083/jcb.144.2.351
Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis, Developmental Cell, vol.14, issue.6, pp.818-847, 2008. ,
DOI : 10.1016/j.devcel.2008.05.009
Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia, The Journal of Cell Biology, vol.130, issue.2, pp.461-71, 1995. ,
DOI : 10.1083/jcb.130.2.461
Cell Adhesion Molecule L1 Disrupts E-Cadherin-Containing Adherens Junctions and Increases Scattering and Motility of MCF7 Breast Carcinoma Cells, Cancer Research, vol.66, issue.23, pp.11370-80, 2006. ,
DOI : 10.1158/0008-5472.CAN-06-2106
The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells, Nature Cell Biology, vol.17, issue.2, pp.84-93, 2000. ,
DOI : 10.1083/jcb.111.3.1265
The transcription factor Snail controls epithelial???mesenchymal transitions by repressing E-cadherin expression, Nature Cell Biology, vol.51, issue.2, pp.76-83, 2000. ,
DOI : 10.1006/dbio.1998.9047
Kruppellike factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion ,
The SLUG zinc-finger protein represses Ecadherin in breast cancer, Cancer Res, vol.62, issue.6, pp.1613-1621, 2002. ,
The Two-Handed E Box Binding Zinc Finger Protein SIP1 Downregulates E-Cadherin and Induces Invasion, Molecular Cell, vol.7, issue.6, pp.1267-78, 2001. ,
DOI : 10.1016/S1097-2765(01)00260-X
Crystal structure of transcription factor E47: E-box recognition by a basic region helix-loop-helix dimer., Genes & Development, vol.8, issue.8, pp.970-80, 1994. ,
DOI : 10.1101/gad.8.8.970
The role of the ZEB family of transcription factors in development and disease, Cellular and Molecular Life Sciences, vol.66, issue.5, pp.773-87, 2009. ,
DOI : 10.1007/s00018-008-8465-8
SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions, Nucleic Acids Research, vol.33, issue.20, pp.6566-78, 2005. ,
DOI : 10.1093/nar/gki965
Evidence for a function of CtBP in epithelial gene regulation and anoikis, Oncogene, vol.19, issue.33, pp.3823-3831, 2000. ,
DOI : 10.1038/sj.onc.1203721
Coordinated histone modifications mediated by a CtBP co-repressor complex, Nature, vol.10, issue.6933, pp.735-743, 2003. ,
DOI : 10.1038/nature01550
Nuclear Speckle-Associated Protein Pnn/DRS Binds to the Transcriptional Corepressor CtBP and Relieves CtBP- Mediated Repression of the E-Cadherin Gene, Molecular and Cellular Biology, vol.24, issue.23, pp.10223-10258, 2004. ,
DOI : 10.1128/MCB.24.23.10223-10235.2004
THE SNAIL SUPERFAMILY OF ZINC-FINGER TRANSCRIPTION FACTORS, Nature Reviews Molecular Cell Biology, vol.3, issue.3, pp.155-66, 2002. ,
DOI : 10.1038/nrm757
The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors, Journal of Cell Science, vol.116, issue.3, pp.499-511, 2003. ,
DOI : 10.1242/jcs.00224
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?, Nature Reviews Cancer, vol.176, issue.6, pp.415-443, 2007. ,
DOI : 10.1038/nrc2131
Snail blocks the cell cycle and confers resistance to cell death Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress, Genes Dev Mol Cell Biol, vol.1824, issue.3817, pp.1131-437559, 2004. ,
Cancer Metastasis Is Accelerated through Immunosuppression during Snail-Induced EMT of Cancer Cells, Cancer Cell, vol.15, issue.3 ,
DOI : 10.1016/j.ccr.2009.01.023
Snail mediates E-cadherin repression by the recruitment of the Sin3A, HDAC1)/HDAC2 complex, pp.306-325, 2004. ,
Polycomb Complex 2 Is Required for E-cadherin Repression by the Snail1 Transcription Factor, Molecular and Cellular Biology, vol.28, issue.15, pp.4772-81, 2008. ,
DOI : 10.1128/MCB.00323-08
Interaction of short-range repressors with ,
Snail promotes Wnt target gene expression and interacts with ??-catenin, Oncogene, vol.3, issue.37, pp.5075-80, 2008. ,
DOI : 10.1038/ncb1173
Dual regulation of Snail by GSK-3??-mediated phosphorylation in control of epithelial???mesenchymal transition, Nature Cell Biology, vol.60, issue.10, pp.931-971, 2004. ,
DOI : 10.1002/(SICI)1097-0142(19991201)86:11<2259::AID-CNCR13>3.0.CO;2-2
Small C-terminal Domain Phosphatase Enhances Snail Activity through Dephosphorylation, Journal of Biological Chemistry, vol.284, issue.1, pp.640-648, 2009. ,
DOI : 10.1074/jbc.M806916200
Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMPactivated kinase protein kinase A, Mol Biol Cell, vol.21, issue.2, pp.244-53 ,
Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions, Cancer Res, vol.65, issue.8, pp.3179-84, 2005. ,
A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression, EMBO J, vol.24, pp.3446-58, 2005. ,
The Hypoxia-controlled FBXL14 Ubiquitin Ligase Targets SNAIL1 for Proteasome Degradation, Journal of Biological Chemistry, vol.285, issue.6, pp.3794-805 ,
DOI : 10.1074/jbc.M109.065995
Human Slug is a repressor that localizes to sites of active transcription Slug stability is dynamically regulated during neural crest development by the F-box protein Ppa, Mol Cell Biol Development, vol.20133, issue.5517, pp.5087-953359, 2000. ,
p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug, Nature Cell Biology, vol.17, issue.6, pp.694-704, 2009. ,
DOI : 10.1158/1078-0432.CCR-06-1743
A novel Snail-related transcription factor Smuc regulates basic helix-loop-helix transcription factor activities via specific E-box motifs, Nucleic Acids Research, vol.28, issue.2, pp.626-659, 2000. ,
DOI : 10.1093/nar/28.2.626
Slug Antagonizes p53-Mediated Apoptosis of Hematopoietic Progenitors by Repressing puma, Cell, vol.123, issue.4, pp.641-53, 2005. ,
DOI : 10.1016/j.cell.2005.09.029
Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK, J Cell Biol, vol.163, issue.4, pp.847-57, 2003. ,
URL : https://hal.archives-ouvertes.fr/inserm-00148047
Erk5 Controls Slug Expression and Keratinocyte Activation during Wound Healing, Molecular Biology of the Cell, vol.19, issue.11, pp.4738-4787, 2008. ,
DOI : 10.1091/mbc.E07-10-1078
URL : https://hal.archives-ouvertes.fr/inserm-00318681
Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail, The EMBO Journal, vol.65, issue.15 ,
DOI : 10.1038/ncb1173
A 3' Enhancer Controls Snail Expression in Melanoma Cells, Cancer Research, vol.67, issue.13, pp.6113-6133, 2007. ,
DOI : 10.1158/0008-5472.CAN-06-4256
Snail1 transcriptional repressor binds to its own promoter and controls its expression, Nucleic Acids Research, vol.34, issue.7, pp.2077-84, 2006. ,
DOI : 10.1093/nar/gkl141
Feedback control of intercellular signalling in development, Nature, vol.408, issue.6810, pp.313-322, 2000. ,
DOI : 10.1038/35042500
Cooperative action of Sox9, Snail2 and PKA signaling in early neural crest development, Development, vol.133, issue.7, pp.1323-1356, 2006. ,
DOI : 10.1242/dev.02297
Genetic Profiling of Epithelial Cells Expressing E-Cadherin Repressors Reveals a Distinct Role for Snail, Slug, and E47 Factors in Epithelial-Mesenchymal Transition, Cancer Research, vol.66, issue.19 ,
DOI : 10.1158/0008-5472.CAN-06-0479
SPARC Represses E-Cadherin and Induces Mesenchymal Transition during Melanoma Development, Cancer Research, vol.66, issue.15, pp.7516-7539, 2006. ,
DOI : 10.1158/0008-5472.CAN-05-3189
URL : http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.322.8079
Activation of NF-??B by Akt upregulates Snail expression and induces epithelium mesenchyme transition, Oncogene, vol.6, issue.53, pp.7445-56, 2007. ,
DOI : 10.1038/sj.onc.1210546
Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition, Oncogene J Cell Biol, vol.23168, issue.721, pp.7345-5429, 2004. ,
Loss of E-cadherin leads to upregulation of NF??B activity in malignant melanoma, Oncogene, vol.23, issue.52, pp.8509-8528, 2004. ,
DOI : 10.1038/sj.onc.1207831
A Signaling Pathway Involving TGF-??2 and Snail in Hair Follicle Morphogenesis, PLoS Biology, vol.6, issue.1, p.11, 2005. ,
DOI : 10.1371/journal.pbio.0030011.g006
The Transcription Factor Snail Mediates Epithelial to Mesenchymal Transitions by Repression of Estrogen Receptor-??, Molecular Endocrinology, vol.21, issue.12, pp.2907-2925, 2007. ,
DOI : 10.1210/me.2007-0293
Unraveling signalling cascades for the Snail family of transcription factors, Cellular Signalling, vol.17, issue.5, pp.535-582, 2005. ,
DOI : 10.1016/j.cellsig.2004.10.011
Snail Induction of Epithelial to Mesenchymal Transition in Tumor Cells Is Accompanied by MUC1 Repression andZEB1 Expression, Journal of Biological Chemistry, vol.277, issue.42, pp.39209-39225, 2002. ,
DOI : 10.1074/jbc.M206400200
A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition, Genes & Development, vol.22, issue.6, pp.756-69, 2008. ,
DOI : 10.1101/gad.455708
Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling, Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells, pp.369-871398, 2001. ,
Stabilization of Snail by NF-??B Is Required for Inflammation-Induced Cell Migration and Invasion, Cancer Cell, vol.15, issue.5, pp.416-444, 2009. ,
DOI : 10.1016/j.ccr.2009.03.016
Key stages in mammary gland development: the mammary end bud as a motile organ Kouros-Mehr H, Werb Z. Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis, Breast Cancer Res Dev Dyn, vol.7235, issue.8512, pp.245-513404, 2005. ,
pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up, Histopathology, vol.9, issue.5, pp.403-413, 1991. ,
DOI : 10.1016/0277-5379(88)90171-X
Requirement of the Akt/??-Catenin Pathway for Uterine Carcinosarcoma Genesis, Modulating E-Cadherin Expression Through the Transactivation of Slug, The American Journal of Pathology, vol.174, issue.6, pp.2107-2122, 2009. ,
DOI : 10.2353/ajpath.2009.081018
Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas, Am J Pathol Perou CM, vol.143, issue.91, pp.1731-1773, 1993. ,
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications, Proceedings of the National Academy of Sciences, vol.98, issue.19, pp.10869-74, 2001. ,
DOI : 10.1073/pnas.191367098
Breast cancer, stem/progenitor cells and the estrogen receptor, Trends in Endocrinology & Metabolism, vol.15, issue.5, pp.193-200, 2004. ,
DOI : 10.1016/j.tem.2004.05.011
Overexpression of c-myc induces epithelial mesenchymal transition in mammary epithelial cells. Cancer Lett. 95 A positive role for Myc in TGFbeta-induced Snail transcription and epithelial-to-mesenchymal transition, Oncogene, vol.28, issue.3, pp.422-452, 2009. ,
gene expression, The Journal of Pathology, vol.12, issue.1, pp.25-37, 2008. ,
DOI : 10.1002/path.2254
Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype, Cancer Res, vol.68, issue.4, pp.989-97, 2008. ,
Triple-negative breast carcinoma in women from Vietnam and the United States: characterization of differential marker expression by tissue microarray, Human Pathology, vol.40, issue.8, pp.1176-81, 2009. ,
DOI : 10.1016/j.humpath.2009.01.003
Breast Cancer Stem Cells and Intrinsic Subtypes: Controversies Rage On, Current Stem Cell Research & Therapy, vol.4, issue.1, pp.50-60, 2009. ,
DOI : 10.2174/157488809787169110
A Novel Lung Metastasis Signature Links Wnt Signaling with Cancer Cell Self-Renewal and Epithelial-Mesenchymal Transition in Basal-like Breast Cancer, Cancer Research, vol.69, issue.13, pp.5364-73, 2009. ,
DOI : 10.1158/0008-5472.CAN-08-4135
Proceedings of the Third International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: Conference Summary Statement, Proceedings of the Third International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: conference summary statement, pp.327-330, 2004. ,
DOI : 10.1158/1078-0432.CCR-031213
Snail1 Protein in the Stroma as a New Putative Prognosis Marker for Colon Tumours, PLoS ONE, vol.67, issue.5, p.5595, 2009. ,
DOI : 10.1371/journal.pone.0005595.t002
Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors, Genome Biology, vol.8, issue.5, p.76, 2007. ,
DOI : 10.1186/gb-2007-8-5-r76
Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer, Cancer Research, vol.68, issue.3, pp.937-982, 2008. ,
DOI : 10.1158/0008-5472.CAN-07-2148
Expression profiling of epithelial plasticity in tumor progression, Oncogene, vol.22, issue.46, pp.7155-69, 2003. ,
DOI : 10.1038/sj.onc.1206887
p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo, Proceedings of the National Academy of Sciences, vol.106, issue.45, pp.19035-19044, 2009. ,
DOI : 10.1073/pnas.0910009106
Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer, Biochemical and Biophysical Research Communications, vol.385, issue.3, pp.307-320, 2009. ,
DOI : 10.1016/j.bbrc.2009.05.048
Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells, Stem Cells, vol.26, issue.9, pp.2059-68, 2009. ,
DOI : 10.1002/stem.154
Opinion: Migrating cancer stem cells ??? an integrated concept of malignant tumour progression, Nature Reviews Cancer, vol.18, issue.9, pp.744-753, 2005. ,
DOI : 10.1038/nrm757
Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1, Proceedings of the National Academy of Sciences, vol.106, issue.48 ,
DOI : 10.1073/pnas.0910962106
Targeted therapies in control of EMT in carcinoma and fibrosis, Drug Discovery Today: Disease Mechanisms, vol.4, issue.4, 2008. ,
DOI : 10.1016/j.ddmec.2008.06.002