Mechanisms of induction and expression of long-term depression at GABAergic synapses in the neonatal rat hippocampus.

Abstract : Synaptic plasticity at excitatory glutamatergic synapses is believed to be instrumental in the maturation of neuronal networks. Using whole-cell patch-clamp recordings, we have studied the mechanisms of induction and expression of long-term depression at excitatory GABAergic synapses in the neonatal rat hippocampus (LTD(GABA-A)). We report that the induction of LTD(GABA-A) requires a GABA(A) receptor-mediated membrane depolarization, which is necessary to remove the Mg(2+) block from postsynaptic NMDA receptors. LTD(GABA-A) is associated with an increase in the coefficient of variation of evoked GABA(A) receptor-mediated synaptic currents and a decrease in the frequency, but not amplitude, of Sr(2+)-induced asynchronous GABA(A) quantal events. We conclude that LTD(GABA-A) induction requires the activation of both GABA(A) and NMDA postsynaptic receptors and that its expression is likely presynaptic.
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Journal of Neuroscience, Society for Neuroscience, 1999, 19 (17), pp.7568-77
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http://www.hal.inserm.fr/inserm-00484950
Contributeur : Olivier Caillard <>
Soumis le : mercredi 19 mai 2010 - 15:38:44
Dernière modification le : mercredi 19 mai 2010 - 18:00:43

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  • HAL Id : inserm-00484950, version 1
  • PUBMED : 10460263

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Olivier Caillard, Yehezkel Ben-Ari, Jean-Luc Gaïarsa. Mechanisms of induction and expression of long-term depression at GABAergic synapses in the neonatal rat hippocampus.. Journal of Neuroscience, Society for Neuroscience, 1999, 19 (17), pp.7568-77. 〈inserm-00484950〉

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