Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy.

Abstract : Impaired inhibition is thought to be important in temporal lobe epilepsy (TLE), the most common form of epilepsy in adult patients. We report that, in experimental TLE, spontaneous GABAergic inhibition was increased in the soma but reduced in the dendrites of pyramidal neurons. The former resulted from the hyperactivity of somatic projecting interneurons, whereas the latter was probably due to the degeneration of a subpopulation of dendritic projecting interneurons. A deficit in dendritic inhibition could reduce seizure threshold, whereas enhanced somatic inhibition would prevent the continuous occurrence of epileptiform activity.
Type de document :
Article dans une revue
Nature Neuroscience, Nature Publishing Group, 2001, 4 (1), pp.52-62. 〈10.1038/82900〉
Liste complète des métadonnées

Littérature citée [48 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00484880
Contributeur : Roman Tyzio <>
Soumis le : mercredi 19 mai 2010 - 13:46:29
Dernière modification le : vendredi 2 février 2018 - 01:21:43
Document(s) archivé(s) le : jeudi 1 décembre 2016 - 00:53:30

Fichier

 Accès restreint
Fichier visible le : jamais

Connectez-vous pour demander l'accès au fichier

Identifiants

Collections

Citation

Rosa Cossart, Céline Dinocourt, June Hirsch, A. Merchan-Perez, J. De Felipe, et al.. Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy.. Nature Neuroscience, Nature Publishing Group, 2001, 4 (1), pp.52-62. 〈10.1038/82900〉. 〈inserm-00484880〉

Partager

Métriques

Consultations de la notice

86