Trophic actions of GABA on neuronal development.

Abstract : During brain development, transmitter-gated receptors are operative before synapse formation, suggesting that their action is not restricted to synaptic transmission. GABA, which is the principal excitatory transmitter in the developing brain, acts as an epigenetic factor to control processes including cell proliferation, neuroblast migration and dendritic maturation. These effects appear to be mediated through a paracrine, diffuse, non-synaptic mode of action that precedes the more focused, rapid mode of operation characteristic of synaptic connections. This sequential operation implies that GABA is used as an informative agent but in a unique context at an early developmental stage. This sequence also implies that by altering these effects, drugs acting on the GABA system could be pathogenic during pregnancy.
Type de document :
Article dans une revue
Trends in Neurosciences, Elsevier, 2005, 28 (6), pp.278-83. 〈10.1016/j.tins.2005.03.010〉
Liste complète des métadonnées

http://www.hal.inserm.fr/inserm-00484557
Contributeur : Roman Tyzio <>
Soumis le : mardi 18 mai 2010 - 15:48:11
Dernière modification le : lundi 19 janvier 2015 - 11:49:49
Document(s) archivé(s) le : mercredi 30 novembre 2016 - 22:00:14

Fichier

 Accès restreint
Fichier visible le : jamais

Connectez-vous pour demander l'accès au fichier

Identifiants

Collections

Citation

Alfonso Represa, Yehezkel Ben-Ari. Trophic actions of GABA on neuronal development.. Trends in Neurosciences, Elsevier, 2005, 28 (6), pp.278-83. 〈10.1016/j.tins.2005.03.010〉. 〈inserm-00484557〉

Partager

Métriques

Consultations de la notice

58