[Efficacy and safety of ixabepilone (BMS-247550), a novel epothilone B analogue]

Abstract : The epothilones are a new class of non-taxane tubulin polymerization agents obtained by natural fermentation of the myxobacteria Sorangium cellulosum. The cytotoxic activities of the epothilones, like those of the taxanes, have been linked to stabilization of microtubules, but they also have important differences. Among the epothilone family, ixabepilone (BMS247550) is a semisynthetic derivative of the natural product epothilone B. Ixabepilone was evaluated in vivo in a panel of human and rodent tumour models, the majority of which were chosen because of their known, well-characterized resistance to paclitaxel, and seems able to overcome the over-expression of multidrug resistance and to be unaffected by mutations in the beta tubulin gene. The interest of ixabepilone was clinically confirmed in clinical studies of phase II which demonstrated a strong activity at the patients with metastatic breast cancer resistant to taxanes and in patients suffering of other types of chemoresistant tumors.
Type de document :
Article dans une revue
Bulletin du Cancer, John Libbey Eurotext, 2008, 95 (2), pp.197-204. 〈10.1684/bdc.2008.0577〉
Liste complète des métadonnées

http://www.hal.inserm.fr/inserm-00484239
Contributeur : Philippe Saas <>
Soumis le : mardi 18 mai 2010 - 11:01:10
Dernière modification le : jeudi 15 février 2018 - 08:48:14

Identifiants

Collections

Citation

Cristian Villanueva, Armelle Dufresne, Xavier Pivot, Erika Viel. [Efficacy and safety of ixabepilone (BMS-247550), a novel epothilone B analogue]. Bulletin du Cancer, John Libbey Eurotext, 2008, 95 (2), pp.197-204. 〈10.1684/bdc.2008.0577〉. 〈inserm-00484239〉

Partager

Métriques

Consultations de la notice

60