P. Genton, When antiepileptic drugs aggravate epilepsy, Brain and Development, vol.22, issue.2, pp.75-80, 2000.
DOI : 10.1016/S0387-7604(99)00113-8

L. Holmes, E. Harvey, and B. Coull, The Teratogenicity of Anticonvulsant Drugs, New England Journal of Medicine, vol.344, issue.15, pp.1132-1138, 2001.
DOI : 10.1056/NEJM200104123441504

G. Anderson, A Mechanistic Approach to Antiepileptic Drug Interactions, Annals of Pharmacotherapy, vol.36, issue.3, pp.554-563, 1998.
DOI : 10.1016/S0009-9236(96)90130-7

E. Tanaka, Clinically significant pharmacokinetic drug interactions between antiepileptic drugs, Journal of Clinical Pharmacy and Therapeutics, vol.35, issue.2, pp.87-92, 1999.
DOI : 10.1046/j.1365-2710.1998.00086.x

N. Cazali, A. Tran, and J. Treluyer, Inhibitory effect of stiripentol on carbamazepine and saquinavir metabolism in human, British Journal of Clinical Pharmacology, vol.63, issue.5, pp.526-536, 2003.
DOI : 10.1046/j.0306-5251.2003.01919.x

C. Chiron, M. Marchand, and A. Tran, Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedicated trial, The Lancet, vol.356, issue.9242, pp.1638-1642, 2000.
DOI : 10.1016/S0140-6736(00)03157-3

R. Finnell, G. Bennett, and J. Slattery, Effect of treatment with phenobarbital and stiripentol on carbamazepine-induced teratogenicity and reactive metabolite formation, Teratology, vol.14, issue.6, pp.324-332, 1995.
DOI : 10.1002/tera.1420520603

R. Levy, A. Rettenmeier, and G. Anderson, Effects of polytherapy with phenytoin, carbamazepine, and stiripentol on formation of 4-ene-valproate, a hepatotoxic metabolite of valproic acid, Clinical Pharmacology & Therapeutics, vol.48, issue.3, pp.225-225, 1990.
DOI : 10.1038/clpt.1990.144

R. Levy, P. Loiseau, and M. Guyot, Stiripentol kinetics in epilepsy: Nonlinearity and interactions, Clinical Pharmacology and Therapeutics, vol.36, issue.5, pp.661-669, 1984.
DOI : 10.1038/clpt.1984.237

T. Thanh, C. Chiron, and G. Dellatolas, Efficacit?? et tol??rance ?? long terme du stiripentol dans le traitement de l?????pilepsie myoclonique s??v??re du nourrisson (syndrome de Dravet), Archives de P??diatrie, vol.9, issue.11, pp.1120-1127, 2002.
DOI : 10.1016/S0929-693X(02)00090-8

J. Perez, C. Chiron, and C. Musial, Stiripentol: Efficacy and Tolerability in Children with Epilepsy, Epilepsia, vol.61, issue.11, pp.1618-1626, 1999.
DOI : 10.1016/S0920-1211(96)00028-9

M. Poisson, F. Huguet, and A. Savattier, A new type of anticonvulsant , stiripentol: pharmacological profile and neurochemical study, Arzneimittelforschung, vol.34, pp.199-204, 1984.

D. Shen, R. Levy, and M. Moor, Efficacy of stiripentol in the intravenous pentylenetetrazol infusion seizure model in the rat, Epilepsy Research, vol.7, issue.1, pp.40-48, 1990.
DOI : 10.1016/0920-1211(90)90052-W

J. Lockard, R. Levy, and P. Rhodes, Stiripentol in Acute/Chronic Efficacy Tests in Monkey Model, Epilepsia, vol.23, issue.6, pp.704-712, 1985.
DOI : 10.1016/0006-2952(73)90383-3

R. Wegmann, A. Ilies, and M. Aurousseau, [Pharmaco-cellular enzymology of the mechanism of action of stiripentol in cardiazolinduced epilepsy, III: protein, nucleoprotein, lipid, and proteoglycan metabolism], Cell Mol Biol, vol.23, pp.455-480, 1978.

A. Tran, F. Vauzelle-kervroedan, and E. Rey, Effect of stiripentol on carbamazepine plasma concentration and metabolism in epileptic children, European Journal of Clinical Pharmacology, vol.50, issue.6, pp.497-500, 1996.
DOI : 10.1007/s002280050147

J. Farwell, G. Anderson, and B. Kerr, Stiripentol in Atypical Absence Seizures in Children: An Open Trial, Epilepsia, vol.33, issue.2, pp.305-311, 1993.
DOI : 10.1016/S0140-6736(85)90420-9

J. Solis and R. Nicoll, Postsynaptic action of endogenous GABA released by nipecotic acid in the hippocampus, Neuroscience Letters, vol.147, issue.1, pp.16-20, 1992.
DOI : 10.1016/0304-3940(92)90764-X

L. Borden, M. Dhar, T. Smith, and K. , Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1, European Journal of Pharmacology: Molecular Pharmacology, vol.269, issue.2, pp.219-224, 1994.
DOI : 10.1016/0922-4106(94)90089-2

P. Suzdak, K. Frederiksen, and K. Andersen, NNC-711, a novel potent and selective ??-aminobutyric acid uptake inhibitor: pharmacological characterization, European Journal of Pharmacology, vol.224, issue.2-3, pp.189-198, 1992.
DOI : 10.1016/0014-2999(92)90804-D

L. Borden, T. Dhar, and K. Smith, Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site, Receptor Channels, vol.2, pp.207-213, 1994.

G. Hofner and K. Wanner, Evaluation of GABA uptake in subcellular fractions of bovine frontal cortex and brainstem, Neuroscience Letters, vol.364, issue.1, pp.53-57, 2004.
DOI : 10.1016/j.neulet.2004.04.025

J. Isaacson, J. Solis, and R. Nicoll, Local and diffuse synaptic actions of GABA in the hippocampus, Neuron, vol.10, issue.2, pp.165-175, 1993.
DOI : 10.1016/0896-6273(93)90308-E

A. Draguhn and U. Heinemann, Different mechanisms regulate IPSC kinetics in early postnatal and juvenile hippocampal granule cells, J Neurophysiol, vol.76, pp.3983-3993, 1996.

S. Sipila, K. Huttu, and J. Voipio, GABA Uptake via GABA Transporter-1 Modulates GABAergic Transmission in the Immature Hippocampus, Journal of Neuroscience, vol.24, issue.26, pp.5877-5880, 2004.
DOI : 10.1523/JNEUROSCI.1287-04.2004

C. Frahm, D. Engel, and A. Draguhn, Efficacy of background GABA uptake in rat hippocampal slices, Neuroreport, vol.12, issue.8, pp.1593-1596, 2001.
DOI : 10.1097/00001756-200106130-00016

F. Nakamura, S. Suzuki, and S. Nishimura, Effects of Clobazam and Its Active Metabolite on GABA-Activated Currents in Rat Cerebral Neurons in Culture, Epilepsia, vol.5, issue.8, pp.728-735, 1996.
DOI : 10.1038/376122a0

M. Cunningham, G. Woodhall, and R. Jones, Valproate modifies spontaneous excitation and inhibition at cortical synapses in vitro, Neuropharmacology, vol.45, issue.7, pp.907-917, 2003.
DOI : 10.1016/S0028-3908(03)00270-3

G. Hollrigel and I. Soltesz, Slow kinetics of miniature IPSCs during early postnatal development in granule cells of the dentate gyrus, J Neurosci, vol.17, pp.5119-5147, 1997.

A. Cohen, D. Lin, and G. Quirk, receptors in epileptic hippocampus: enhanced synaptic efficacy and altered pharmacology, European Journal of Neuroscience, vol.85, issue.8, pp.1607-1616, 2003.
DOI : 10.1046/j.1460-9568.2003.02597.x

T. Defazio and J. Hablitz, Zinc and zolpidem modulate mIPSCs in rat neocortical pyramidal neurons, J Neurophysiol, vol.80, pp.1670-1677, 1998.

T. Otis and I. Mody, Modulation of decay kinetics and frequency of GABAA receptor-mediated spontaneous inhibitory postsynaptic currents in hippocampal neurons, Neuroscience, vol.49, issue.1, pp.13-32, 1992.
DOI : 10.1016/0306-4522(92)90073-B

C. Leroy, P. Poisbeau, and A. Keller, receptors at dentate gyrus synapses in a rat model of temporal lobe epilepsy, The Journal of Physiology, vol.50, issue.2, pp.473-487, 2004.
DOI : 10.1113/jphysiol.2003.059246
URL : https://hal.archives-ouvertes.fr/hal-00142909

D. Belelli and J. Lambert, Neurosteroids: endogenous regulators of the GABAA receptor, Nature Reviews Neuroscience, vol.50, issue.7, p.xx?xx, 2005.
DOI : 10.1016/j.bcp.2004.07.025

J. Lambert, D. Belelli, and D. Peden, Neurosteroid modulation of GABAA receptors, Progress in Neurobiology, vol.71, issue.1, pp.67-80, 2003.
DOI : 10.1016/j.pneurobio.2003.09.001

J. Lambert, D. Belelli, and C. Hill-venning, Neurosteroids and GABAA receptor function, Trends in Pharmacological Sciences, vol.16, issue.9, pp.295-303, 1995.
DOI : 10.1016/S0165-6147(00)89058-6

S. Harney, B. Frenguelli, and J. Lambert, Phosphorylation influences neurosteroid modulation of synaptic GABAA receptors in rat CA1 and dentate gyrus neurones, Neuropharmacology, vol.45, issue.6, pp.873-883, 2003.
DOI : 10.1016/S0028-3908(03)00251-X

M. Park-chung, A. Malayev, and R. Purdy, Sulfated and unsulfated steroids modulate ??-aminobutyric acidA receptor function through distinct sites, Brain Research, vol.830, issue.1, pp.72-87, 1999.
DOI : 10.1016/S0006-8993(99)01381-5

S. Sullivan and S. Moenter, Neurosteroids Alter ??-Aminobutyric Acid Postsynaptic Currents in Gonadotropin-Releasing Hormone Neurons: A Possible Mechanism for Direct Steroidal Control, Endocrinology, vol.144, issue.10, pp.4366-4375, 2003.
DOI : 10.1210/en.2003-0634

L. Zhang, J. Weiner, and P. Carlen, Potentiation of gammaaminobutyric acid type A receptor-mediated synaptic currents by pentobarbital and diazepam in immature hippocampal CA1 neurons, J Pharmacol Exp Ther, vol.266, pp.1227-1235, 1993.

C. Rovira and Y. Ben-ari, Developmental study of miniature IPSCs of CA3 hippocampal cells: modulation by midazolam, Developmental Brain Research, vol.114, issue.1, pp.79-88, 1999.
DOI : 10.1016/S0165-3806(99)00022-X
URL : https://hal.archives-ouvertes.fr/inserm-00486255

M. Lim, C. Lindquist, and B. Birnir, Effects of pentobarbital on GABA-activated currents in acutely-isolated rat dentate gyrus granule neurons, Neuroscience Letters, vol.353, issue.2, pp.139-142, 2003.
DOI : 10.1016/j.neulet.2003.09.025

J. Dalziel, G. Cox, and P. Gage, Mutant human ??1??1(T262Q) GABAA receptors are directly activated but not modulated by pentobarbital, European Journal of Pharmacology, vol.385, issue.2-3, pp.283-286, 1999.
DOI : 10.1016/S0014-2999(99)00710-4

J. Rho, S. Donevan, and M. Rogawski, Direct activation of GABAA receptors by barbiturates in cultured rat hippocampal neurons., The Journal of Physiology, vol.497, issue.2, pp.509-522, 1996.
DOI : 10.1113/jphysiol.1996.sp021784

S. Thompson, P. Whiting, and K. Wafford, Barbiturate interactions at the human GABAA receptor: dependence on receptor subunit combination, British Journal of Pharmacology, vol.270, issue.3, pp.521-528, 1996.
DOI : 10.1111/j.1476-5381.1996.tb15221.x

M. Eghbali, P. Gage, and B. Birnir, Pentobarbital modulates gammaaminobutyric acid-activated single-channel conductance in rat cultured hippocampal neurons, Mol Pharmacol, vol.58, pp.463-469, 2000.

D. Engel, D. Schmitz, and T. Gloveli, Laminar difference in GABA uptake and GAT-1 expression in rat CA1, The Journal of Physiology, vol.373, issue.3, pp.643-649, 1998.
DOI : 10.1111/j.1469-7793.1998.643bd.x

A. Lehmenkuhler, E. Sykova, and J. Svoboda, Extracellular space parameters in the rat neocortex and subcortical white matter during postnatal development determined by diffusion analysis, Neuroscience, vol.55, issue.2, pp.339-351, 1993.
DOI : 10.1016/0306-4522(93)90503-8

K. Holland, D. Canney, and S. Rothman, Physiological modulation of the GABA receptor by convulsant and anticonvulsant barbiturates in cultured rat hippocampal neurons, Brain Research, vol.516, issue.1, pp.147-150, 1990.
DOI : 10.1016/0006-8993(90)90910-4

R. Twyman, C. Rogers, and R. Macdonald, Differential regulation of ?-aminobutyric acid receptor channels by diazepam and phenobarbital, Annals of Neurology, vol.13, issue.3, pp.213-220, 1989.
DOI : 10.1002/ana.410250302

J. Bikker, J. Kubanek, and D. Weaver, Quantum Pharmacologic Studies Applicable to the Design of Anticonvulsants: Theoretical Conformational Analysis and Structure-Activity Studies of Barbiturates, Epilepsia, vol.77, issue.2, pp.411-425, 1994.
DOI : 10.1007/BF01557723

P. Fatt and B. Katz, Spontaneous subthreshold activity at motor nerve endings, J Physiol, vol.117, pp.109-128, 1952.

S. Duffy, P. Nguyen, and G. Baker, Phenylethylidenehydrazine, a novel GABA-transaminase inhibitor, reduces epileptiform activity in rat hippocampal slices, Neuroscience, vol.126, issue.2, pp.423-432, 2004.
DOI : 10.1016/j.neuroscience.2004.03.007

W. Loscher and D. Horstermann, Differential effects of vigabatrin, gamma-acetylenic GABA, aminooxyacetic acid, and valproate on levels of various amino acids in rat brain regions and plasma, Naunyn Schmiedebergs Arch Pharmacol, vol.349, pp.270-278, 1994.

J. Wood, E. Kurylo, and R. Lane, ?-Aminobutyric Acid Release from Synaptosomes Prepared from Rats Treated with Isonicotinic Acid Hydrazide and Gabaculine, Journal of Neurochemistry, vol.37, issue.6, pp.1839-1843, 1988.
DOI : 10.1016/0020-711X(81)90178-6

E. Carmona, C. Gomes, and G. Trolin, Effect of aminooxyacetic acid (AOAA) on GABA levels in some parts of the rat brain, Naunyn-Schmiedeberg's Archives of Pharmacology, vol.30, issue.1, pp.51-55, 1980.
DOI : 10.1007/BF00502574

P. Loiseau, E. Strube, and J. Tor, Neurophysiological and therapeutic evaluation of stiripentol in epilepsy: preliminary results], Rev Neurol (Paris), vol.144, pp.165-172, 1988.

C. Chiron, S. Tonnelier, and E. Rey, Stiripentol in Childhood Partial Epilepsy: Randomized Placebo-Controlled Trial with Enrichment and Withdrawal Design, Journal of Child Neurology, vol.49, issue.6, 2005.
DOI : 10.1177/08830738060210062101

S. Czuczwar and P. Patsalos, The New Generation of GABA Enhancers, CNS Drugs, vol.38, issue.5, pp.339-350, 2001.
DOI : 10.2165/00023210-200115050-00001

D. Treiman, GABAergic Mechanisms in Epilepsy, Epilepsia, vol.36, issue.suppl 6, pp.8-12, 2001.
DOI : 10.1046/j.1528-1157.2001.042suppl.3008.x

M. Gasior, J. Ungard, and J. Witkin, Preclinical evaluation of newly approved and potential antiepileptic drugs against cocaine-induced seizures, J Pharmacol Exp Ther, vol.290, pp.1148-1156, 1999.

D. Schulz and R. Macdonald, Barbiturate enhancement of GABA-mediated inhibition and activation of chloride ion conductance: correlation with anticonvulsant and anesthetic actions, Brain Research, vol.209, issue.1, pp.177-188, 1981.
DOI : 10.1016/0006-8993(81)91179-3