W. Gowers, Epilepsy and Other Chronic Convulsive Disorders: Their Causes, Symptoms and Treatment, p.1881

Y. Benari, Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy, Neuroscience, vol.14, issue.2, pp.375-403, 1985.
DOI : 10.1016/0306-4522(85)90299-4

B. Ari, Y. Cossart, and R. , Kainate, a double agent that generates seizures: two decades of progress, Trends Neurosci, vol.23, pp.580-587, 2000.
URL : https://hal.archives-ouvertes.fr/inserm-00485223

J. Nadler, The recurrent mossy fiber pathway of the epileptic brain, Neurochemical Research, vol.28, issue.11, pp.1649-1658, 2003.
DOI : 10.1023/A:1026004904199

V. Crepel, A. Represa, M. Beaudoin, and Y. Benari, Hippocampal damage induced by ischemia and intra-amygdaloid kainate injection: Effects on N-methyl-d-aspartate, N-(1-[2-thienyl]cyclohexyl)piperidine and glycine binding sites, Neuroscience, vol.31, issue.3, pp.605-612, 1989.
DOI : 10.1016/0306-4522(89)90426-0

R. Cossart, Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy, Nat Neurosci, vol.4, pp.52-62, 2001.
URL : https://hal.archives-ouvertes.fr/inserm-00484880

C. Dinocourt, Z. Petanjek, T. Freund, B. Ari, Y. Esclapez et al., Loss of interneurons innervating pyramidal cell dendrites and axon initial segments in the CA1 region of the hippocampus following pilocarpine-induced seizures, The Journal of Comparative Neurology, vol.459, issue.4, pp.407-425, 2003.
DOI : 10.1002/cne.10622

URL : https://hal.archives-ouvertes.fr/inserm-00484796

F. Dudek and L. Shao, Loss of GABAergic Interneurons in Seizure-induced Epileptogenesis, Epilepsy Currents, vol.3, issue.5, pp.159-161, 2003.
DOI : 10.1046/j.1535-7597.2003.03503.x

M. Kobayashi and P. Buckmaster, Reduced inhibition of dentate granule cells in a model of temporal lobe epilepsy, J Neurosci, vol.23, pp.2440-2452, 2003.

A. Obenaus, M. Esclapez, and C. Houser, Loss of glutamatedecarboxylase messenger-Rna containing neurons in the rat dentate gyrus following pilocarpine-induced seizures, J Neurosci, vol.13, pp.4470-4485, 1993.

P. Buckmaster and F. Dudek, Neuron loss, granule cell axon reorganization, and functional changes in the dentate gyrus of epileptic kainate???treated rats, The Journal of Comparative Neurology, vol.385, issue.3, pp.385-404, 1997.
DOI : 10.1002/(SICI)1096-9861(19970901)385:3<385::AID-CNE4>3.3.CO;2-Y

J. Epsztein, A. Represa, I. Jorquera, Y. Ben-ari, and V. Crepel, Recurrent Mossy Fibers Establish Aberrant Kainate Receptor-Operated Synapses on Granule Cells from Epileptic Rats, Journal of Neuroscience, vol.25, issue.36, pp.8229-8239, 2005.
DOI : 10.1523/JNEUROSCI.1469-05.2005

URL : https://hal.archives-ouvertes.fr/inserm-00484549

M. Esclapez, J. Hirsch, B. Ari, Y. Bernard, and C. , Newly formed excitatory pathways provide a substrate for hyperexcitability in experimental temporal lobe epilepsy, The Journal of Comparative Neurology, vol.851, issue.4, pp.449-460, 1999.
DOI : 10.1002/(SICI)1096-9861(19990614)408:4<449::AID-CNE1>3.0.CO;2-R

A. Represa, E. Tremblay, and Y. Benari, Kainate binding sites in the hippocampal mossy fibers: Localization and plasticity, Neuroscience, vol.20, issue.3, pp.739-748, 1987.
DOI : 10.1016/0306-4522(87)90237-5

T. Sutula, G. Cascino, J. Cavazos, I. Parada, and L. Ramirez, Hippocampal synaptic reorganization in partial complex epilepsy ? evidence for mossy fiber sprouting in epileptic human temporal-lobe, Ann Neurol, vol.24, pp.134-135, 1988.

D. Tauck and J. Nadler, Evidence of functional mossy fiber sprouting in hippocampal-formation of kainic acid-treated rats, J Neurosci, vol.5, pp.1016-1022, 1985.

A. Represa, O. Robain, E. Tremblay, B. Ari, and Y. , Hippocampal plasticity in childhood epilepsy, Neuroscience Letters, vol.99, issue.3, pp.351-355, 1989.
DOI : 10.1016/0304-3940(89)90472-2

S. Gabriel, Stimulus and Potassium-Induced Epileptiform Activity in the Human Dentate Gyrus from Patients with and without Hippocampal Sclerosis, Journal of Neuroscience, vol.24, issue.46, pp.10416-10430, 2004.
DOI : 10.1523/JNEUROSCI.2074-04.2004

A. Bragin, C. Wilson, J. Engel, and . Jr, Chronic Epileptogenesis Requires Development of a Network of Pathologically Interconnected Neuron Clusters: A Hypothesis, Epilepsia, vol.1, issue.s6, pp.144-152, 2000.
DOI : 10.1016/0301-0082(91)90011-O

J. Nadler, Kainic acid as a tool for the study of temporal lobe epilepsy, Life Sciences, vol.29, issue.20, pp.2031-2042, 1981.
DOI : 10.1016/0024-3205(81)90659-7

D. Monaghan and C. Cotman, The distribution of [3H]kainic acid binding sites in rat CNS as determined by autoradiography, Brain Research, vol.252, issue.1, pp.91-100, 1982.
DOI : 10.1016/0006-8993(82)90981-7

E. Tremblay, A. Represa, B. Ari, and Y. , Autoradiographic localization of kainic acid binding sites in the human hippocampus, Brain Research, vol.343, issue.2, pp.378-382, 1985.
DOI : 10.1016/0006-8993(85)90761-9

W. Wisden and P. Seeburg, A complex mosaic of high-affinity kainate receptors in rat-brain, J Neurosci, vol.13, pp.3582-3598, 1993.

I. Bureau, S. Bischoff, S. Heinemann, and C. Mulle, Kainate receptormediated responses in the CA1 field of wild-type and GluR6- deficient mice, J Neurosci, vol.19, pp.653-663, 1999.

M. Frerking and R. Nicoll, Synaptic kainate receptors, Current Opinion in Neurobiology, vol.10, issue.3, pp.342-351, 2000.
DOI : 10.1016/S0959-4388(00)00094-5

P. Castillo, R. Malenka, and R. Nicoll, Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons, Nature, vol.388, pp.182-186, 1997.

H. Li and M. Rogawski, GluR5 kainate receptor mediated synaptic transmission in rat basolateral amygdala in vitro, Neuropharmacology, vol.37, issue.10-11, pp.1279-1286, 1998.
DOI : 10.1016/S0028-3908(98)00109-9

S. Devries and E. Schwartz, Kainate receptors mediate synaptic transmission between cones and " off " bipolar cells in a mammalian retina, Nature, vol.397, issue.6715, pp.157-160, 1999.
DOI : 10.1038/16462

F. Kidd and J. Isaac, Developmental and activity-dependent regulation of kainate receptors at thalamocortical synapses, Nature, vol.400, pp.569-573, 1999.

R. Cossart, Quantal Release of Glutamate Generates Pure Kainate and Mixed AMPA/Kainate EPSCs in Hippocampal Neurons, Neuron, vol.35, issue.1, pp.147-159, 2002.
DOI : 10.1016/S0896-6273(02)00753-5

URL : https://hal.archives-ouvertes.fr/inserm-00484870

J. Lerma, Roles and rules of kainate receptors in synaptic transmission, Nature Reviews Neuroscience, vol.4, issue.6, pp.481-495, 2003.
DOI : 10.1038/nrn1118

H. Shinozaki and S. Konishi, Actions of several anthelmintics and insecticides on rat cortical neurones, Brain Research, vol.24, issue.2, pp.368-371, 1970.
DOI : 10.1016/0006-8993(70)90122-8

A. Represa, E. Tremblay, D. Schoevart, B. Ari, and Y. , Development of high affinity kainate binding sites in human and rat hippocampi, Brain Research, vol.384, issue.1, pp.170-174, 1986.
DOI : 10.1016/0006-8993(86)91234-5

J. Mcnamara, M. Byrne, R. Dasheiff, and J. Fitz, The kindling model of epilepsy: A review, Progress in Neurobiology, vol.15, issue.2, pp.139-159, 1980.
DOI : 10.1016/0301-0082(80)90006-4

D. Mcintyre and R. Racine, Kindling mechanisms: Current progress on an experimental epilepsy model, Progress in Neurobiology, vol.27, issue.1, pp.1-12, 1986.
DOI : 10.1016/0301-0082(86)90010-9

J. Olney, V. Rhee, and O. Ho, Kainic acid: a powerful neurotoxic analogue of glutamate, Brain Research, vol.77, issue.3, pp.507-512, 1974.
DOI : 10.1016/0006-8993(74)90640-4

J. Gaiarsa, L. Zagrean, and Y. Benari, Neonatal irradiation prevents the formation of hippocampal mossy fibers and the epileptic action of kainate on rat Ca3 pyramidal neurons, J Neurophysiol, vol.71, pp.204-215, 1994.

L. Nitecka, Maturation of kainic acid seizure-brain damage syndrome in the rat. II. Histopathological sequelae, Neuroscience, vol.13, issue.4, pp.1073-1094, 1984.
DOI : 10.1016/0306-4522(84)90289-6

E. Pinard, E. Tremblay, B. Ari, Y. Seylaz, and J. , Blood flow compensates oxygen demand in the vulnerable ca3 region of the hippocampus during kainate-induced seizures, Neuroscience, vol.13, issue.4, pp.1039-1049, 1984.
DOI : 10.1016/0306-4522(84)90287-2

G. Daoudal and D. Debanne, Long-Term Plasticity of Intrinsic Excitability: Learning Rules and Mechanisms, Learning & Memory, vol.10, issue.6, pp.456-465, 2003.
DOI : 10.1101/lm.64103

T. Wilding and J. Huettner, Differential antagonism of alpha- amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-preferring and kainate-preferring receptors by 2,3-benzodiazepines, Mol Pharmacol, vol.47, pp.582-587, 1995.

S. Donevan and M. Rogawski, GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses, Neuron, vol.10, issue.1, pp.51-59, 1993.
DOI : 10.1016/0896-6273(93)90241-I

C. Mulle, Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice, Nature, vol.392, pp.601-605, 1998.

A. Fisahn, Distinct Roles for the Kainate Receptor Subunits GluR5 and GluR6 in Kainate-Induced Hippocampal Gamma Oscillations, Journal of Neuroscience, vol.24, issue.43, pp.9658-9668, 2004.
DOI : 10.1523/JNEUROSCI.2973-04.2004

I. Khalilov, J. Hirsch, R. Cossart, B. Ari, and Y. , Paradoxical antiepileptic effects of a GluR5 agonist of kainate receptors, J Neurophysiol, vol.88, pp.523-527, 2002.
URL : https://hal.archives-ouvertes.fr/inserm-00484867

J. Wuarin and F. Dudek, Excitatory synaptic input to granule cells increases with time after kainate treatment, J Neurophysiol, vol.85, pp.1067-1077, 2001.

M. Khrestchatisky, Molecular correlates between reactive and developmental plasticity in the rat hippocampus, Journal of Neurobiology, vol.9, issue.3, pp.426-436, 1995.
DOI : 10.1002/neu.480260314

E. Nedivi, D. Hevroni, D. Naot, D. Israeli, and Y. Citri, Numerous candidate plasticity-related genes revealed by differential cDNA cloning, Nature, vol.363, issue.6431, pp.718-722, 1993.
DOI : 10.1038/363718a0

B. Longo, E. Sanabria, S. Gabriel, and L. Mello, Electrophysiologic Abnormalities of the Hippocampus in the Pilocarpine/Cycloheximide Model of Chronic Spontaneous Seizures, Epilepsia, vol.9, issue.suppl 6, pp.203-208, 2002.
DOI : 10.1046/j.1528-1157.43.s.5.4.x

W. Blume, The Progression of Epilepsy, Epilepsia, vol.62, issue.s1, pp.71-78, 2006.
DOI : 10.1002/ana.10692

B. Fritsch, M. Gasior, R. Kaminski, and M. Rowgawski, Role of kainate receptor subunits in seizure induction assessed with kainate receptor knockout mice, Epilepsia, vol.47, issue.4, p.305, 2006.