Apelin signalling: a promising pathway from cloning to pharmacology.

Abstract : The discovery of new signalling pathways is always followed by the development of pharmacological agents as drugs that can be used in the treatment of diseases resulting from a dysfunction of the signalling pathway in question. Apelin signalling plays a role in the central and peripheral regulation of the cardiovascular system, in water and food intake, and possibly in immune function. Up-regulation of ligand and receptor is also associated with pathophysiological states such as cardiac dysfunction and neovascularisation. Finally, the apelin receptor is a coreceptor for the entry of several HIV-1 and SIV strains. In view of these features, the apelin receptor constitutes a very interesting target for the design of new drugs for treating the prime causes of human mortality.
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Cellular Signalling, Elsevier, 2005, 17 (4), pp.415-26. 〈10.1016/j.cellsig.2004.09.018〉
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Contributeur : Marie Francoise Simon <>
Soumis le : mercredi 5 mai 2010 - 17:11:41
Dernière modification le : lundi 10 mai 2010 - 15:45:40

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B. Masri, B. Knibiehler, Y. Audigier. Apelin signalling: a promising pathway from cloning to pharmacology.. Cellular Signalling, Elsevier, 2005, 17 (4), pp.415-26. 〈10.1016/j.cellsig.2004.09.018〉. 〈inserm-00481022〉

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