Long-term follow-up of autologous stem cell transplantation after intensive chemotherapy in patients with myelodysplastic syndrome or secondary acute myeloid leukemia.

Abstract : We report on the outcomes of 53 patients with myelodysplastic syndromes (MDS) or acute myeloid leukemia secondary to MDS, autografted in first complete remission. Five (9.4%) died from the procedure whereas hematological reconstitution occurred in all the remaining patients. Forty patients (75%) relapsed, with 87.5% of the relapses occurring within 2 years of the autologous transplant. With a median follow-up of 6.2 years, the median actuarial disease-free survival and overall survival were 8 and 17 months after autograft, respectively. Karyotype was the only prognostic factor for disease-free and overall survival. The eight survivors (15%), including two patients with unfavorable or intermediate karyotype, remained in first complete remission 50+ to 119+ months after transplantation and are probably cured.
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Haematologica, Ferrata Storti Foundation, 2006, 91 (3), pp.373-6
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  • HAL Id : inserm-00473474, version 1
  • PUBMED : 16531261

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Sophie Ducastelle, Lionel Adès, Claude Gardin, Hervé Dombret, Thomas Prébet, et al.. Long-term follow-up of autologous stem cell transplantation after intensive chemotherapy in patients with myelodysplastic syndrome or secondary acute myeloid leukemia.. Haematologica, Ferrata Storti Foundation, 2006, 91 (3), pp.373-6. 〈inserm-00473474〉

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