3-D real-time motion correction in high-intensity focused ultrasound therapy.: Motion tracking for HIFU therapy

Abstract : A method for tracking the 3-D motion of tissues in real-time is combined with a 2-D high-intensity focused ultrasound (US), or HIFU, multichannel system to correct for respiratory motion during HIFU therapy. Motion estimation is based on an accurate ultrasonic speckle-tracking method. A pulse-echo sequence is performed for a subset of the transducers of the phased array. For each of these subapertures, the displacement is estimated by computing the 1-D cross-correlation of the backscattered signals acquired at two different times. The 3-D motion vector is then computed by a triangulation algorithm. This technique is experimentally validated in phantoms moving as fast as 40 mm s(-1), and combined with HIFU sequences. A real-time feedback correction of the HIFU beam is achieved by adjusting the delays of each channel. The sonications "locked on target" are interleaved with very short motion-estimation sequences. Finally, in vitro experiments of "locked on target" HIFU therapy are performed in fresh moving tissues.
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Ultrasound in Medicine and Biology, Elsevier, 2004, 30 (9), pp.1239-49. 〈10.1016/j.ultrasmedbio.2004.07.021〉
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Mathieu Pernot, Mickaël Tanter, Mathias Fink. 3-D real-time motion correction in high-intensity focused ultrasound therapy.: Motion tracking for HIFU therapy. Ultrasound in Medicine and Biology, Elsevier, 2004, 30 (9), pp.1239-49. 〈10.1016/j.ultrasmedbio.2004.07.021〉. 〈inserm-00468901〉

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