Symptom and quality of life results of an international randomised phase III study of adjuvant vaccination with Bec2/BCG in responding patients with limited disease small-cell lung cancer.

Abstract : AIMS: This study reports the symptom and HRQOL results in which standard treatment was compared to standard therapy plus Bec2, an anti-idiotypic antibody that mimics GD3, a ganglioside antigen. METHODS: Five hundred and fifteen LD SCLC patients were randomised to receive five vaccinations of Bec2 (2.5mg)/BCG vaccine arm (VA) or an observational arm (OA) administered over a 10-week period. Survival was the primary end-point; HRQOL was a secondary end-point, assessed using the EORTC QLQ-C30/LC 13. RESULTS: There was no improvement in survival or progression-free survival in the vaccination arm. At baseline patients in both arms demonstrated significantly impaired scores on the global QOL scale, when compared to a normative population. However, HRQOL and symptom scores between the two treatment arms were not statistically different at any time point. CONCLUSION: We found no benefits to patient HRQOL by additional vaccination with Bec2/BCG to LD SCLC for patients who have been undergoing standard therapy.
Type de document :
Article dans une revue
European Journal of Cancer, Elsevier, 2008, 44 (15), pp.2178-84. 〈10.1016/j.ejca.2008.06.036〉
Liste complète des métadonnées

http://www.hal.inserm.fr/inserm-00467793
Contributeur : Céline Breton <>
Soumis le : lundi 29 mars 2010 - 10:28:54
Dernière modification le : mardi 5 juin 2018 - 10:14:32

Identifiants

Collections

Citation

Andrew Bottomley, Channa Debruyne, Enriqueta Felip, Michael Millward, Luc Thiberville, et al.. Symptom and quality of life results of an international randomised phase III study of adjuvant vaccination with Bec2/BCG in responding patients with limited disease small-cell lung cancer.. European Journal of Cancer, Elsevier, 2008, 44 (15), pp.2178-84. 〈10.1016/j.ejca.2008.06.036〉. 〈inserm-00467793〉

Partager

Métriques

Consultations de la notice

98