PMID: identifiant
de la référence Pubmed : |
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 (20091325) |
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| titre : |
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Mineral maturity and crystallinity index are distinct characteristics of bone mineral. |
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| auteur(s) : |
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Delphine Farlay ( ) 1, Gérard Panczer2, Christian Rey3, Pierre Delmas1, Georges Boivin1 |
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| laboratoire : |
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| résumé : |
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The purpose of this study was to test the hypothesis that mineral maturity and crystallinity index are two different characteristics of bone mineral. To this end, Fourier transform infrared microspectroscopy (FTIRM) was used. To test our hypothesis, synthetic apatites and human bone samples were used for the validation of the two parameters using FTIRM. Iliac crest samples from seven human controls and two with skeletal fluorosis were analyzed at the bone structural unit (BSU) level by FTIRM on sections 2-4 mum thick. Mineral maturity and crystallinity index were highly correlated in synthetic apatites but poorly correlated in normal human bone. In skeletal fluorosis, crystallinity index was increased and maturity decreased, supporting the fact of separate measurement of these two parameters. Moreover, results obtained in fluorosis suggested that mineral characteristics can be modified independently of bone remodeling. In conclusion, mineral maturity and crystallinity index are two different parameters measured separately by FTIRM and offering new perspectives to assess bone mineral traits in osteoporosis. |
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| domaine : |
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Sciences du Vivant/Médecine humaine et pathologie/Rhumatologie et système ostéo-articulaire
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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0914-8779 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1007/s00774-009-0146-7 |
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| journal : |
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| Journal of Bone and Mineral Metabolism (J Bone Miner Metab) |
| Publisher |
Springer-Verlag |
| ISSN |
0914-8779 (eISSN : 1435-5604) |
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| Audience : |
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internationale |
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| date de publication : |
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22/01/2010 |
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date de publication
électronique : |
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22/01/2010 |
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| page, identifiant, ... : |
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epub ahead of print |
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| mots-clés auteur : |
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Bone mineral – Hydrated layer – FTIRM – Mineral maturity – Mineral crystallinity index |
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| contrat, financement : |
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This work was supported in part by an unrestricted educational grant from Eli Lilly to INSERM. |
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