PMID: identifiant
de la référence Pubmed : |
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 (19833631) |
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| titre : |
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Thymosin beta4 has tumor suppressive effects and its decreased expression results in poor prognosis and decreased survival in multiple myeloma. |
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| auteur(s) : |
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Jo Caers1, 2, Dirk Hose3, 4, Ine Kuipers1, Tomas Jan Bos1, Els Van Valckenborgh1, Eline Menu1, Elke De Bruyne1, Hartmut Goldschmidt3, 4, Ben Van Camp1, Bernard Klein5, Karin Vanderkerken ( ) 1 |
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| laboratoire : |
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| résumé : |
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Thymosin beta4 (Tbeta4) is a polypeptide involved in cellular proliferation, differentiation, and migration, over-expressed in several tumor entities. We evaluated its expression and function in 298 newly diagnosed multiple myeloma patients and the murine 5TMM model. Mean Tbeta4 expression was significantly lower in myeloma cells compared to normal plasma cells (P<0.001). The same observation can be made in the 5TMM-mouse model by qRT-PCR and ELISA. Here, Tbeta4 overexpression by lentiviral transduction of 5T33MMvt-cells led to significantly decreased proliferative and migratory capacities and increased sensitivity to apoptosis-induction. Mice injected with Tbeta4 over-expressing myeloma cells showed a longer survival compared to mice injected with controls (88,9 vs. 65,9 days, P<0.05). In 209 MM patients treated with high-dose therapy and autologous stem cell transplantation, expression of Tbeta4 below the median was associated with a significantly shorter event free survival (37.6 vs. 26.2 months, P<0.05). In conclusion, our results indicate a possible tumor suppressive function of Tbeta4. |
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| domaine : |
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Sciences du Vivant/Biochimie, Biologie Moléculaire
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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0390-6078 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.3324/haematol.2009.006411 |
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| journal : |
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| Haematologica (Haematologica) |
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0390-6078 (eISSN : 1592-8721) |
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| Audience : |
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internationale |
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| date de publication : |
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01/2010 |
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date de publication
électronique : |
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14/10/2009 |
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| volume : |
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95 |
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| numéro : |
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1 |
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| page, identifiant, ... : |
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163-7 |
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| mots-clés auteur : |
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thymosin beta – cellular proliferation – multiple myeloma |
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| contrat, financement : |
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the Fund for Scientific Research-Vlaanderen (FWO-Vlaanderen), the Association for International Cancer Research and by a grant from the European Commission FP6 to MSCNET. E Menu is a post-doctoral fellow of FWO-Vlaanderen. |
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