Therapy-induced tumor immunosurveillance involves IFN-producing killer dendritic cells.

Abstract : A unique class of IFN-producing killer dendritic cells (IKDC) resembling natural killer cells has been defined that can recognize and lyse tumor cells through a tumor necrosis factor-related apoptosis-inducing ligand-dependent mechanism. IKDC may mediate the host-dependent antitumor activity of Gleevec/STI571 and other therapeutics that can inhibit the c-kit tyrosine kinase. IKDC represent an important new component of the innate immune system responding to cancer.
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Cancer Research, American Association for Cancer Research, 2007, 67 (3), pp.851-3. 〈10.1158/0008-5472.CAN-06-3766〉
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http://www.hal.inserm.fr/inserm-00451703
Contributeur : Grégoire Mignot <>
Soumis le : vendredi 29 janvier 2010 - 17:37:46
Dernière modification le : vendredi 6 octobre 2017 - 11:44:05

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Evelyn Ullrich, Mathieu Bonmort, Grégoire Mignot, Nathalie Chaput, Julien Taieb, et al.. Therapy-induced tumor immunosurveillance involves IFN-producing killer dendritic cells.. Cancer Research, American Association for Cancer Research, 2007, 67 (3), pp.851-3. 〈10.1158/0008-5472.CAN-06-3766〉. 〈inserm-00451703〉

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