PMID: identifiant
de la référence Pubmed : |
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 (19804369)  |
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| titre : |
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Cartilage tissue engineering: towards a biomaterial-assisted mesenchymal stem cell therapy. |
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| auteur(s) : |
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Claire Vinatier1, 2, Carine Bouffi3, Christophe Merceron1, Jan Gordeladze3, Jean-Marc Brondello3, 4, Christian Jorgensen3, Pierre Weiss1, Jérôme Guicheux1, Danièle Noël ( ) 3 |
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| laboratoire : |
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| résumé : |
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Injuries to articular cartilage are one of the most challenging issues of musculoskeletal medicine due to the poor intrinsic ability of this tissue for repair. Despite progress in orthopaedic surgery, the lack of efficient modalities of treatment for large chondral defects has prompted research on tissue engineering combining chondrogenic cells, scaffold materials and environmental factors. The aim of this review is to focus on the recent advances made in exploiting the potentials of cell therapy for cartilage engineering. These include: 1) defining the best cell candidates between chondrocytes or multipotent progenitor cells, such as multipotent mesenchymal stromal cells (MSC), in terms of readily available sources for isolation, expansion and repair potential; 2) engineering biocompatible and biodegradable natural or artificial matrix scaffolds as cell carriers, chondrogenic factors releasing factories and supports for defect filling, 3) identifying more specific growth factors and the appropriate scheme of application that will promote both chondrogenic differentiation and then maintain the differentiated phenotype overtime and 4) evaluating the optimal combinations that will answer to the functional demand placed upon cartilage tissue replacement in animal models and in clinics. Finally, some of the major obstacles generally encountered in cartilage engineering are discussed as well as future trends to overcome these limiting issues for clinical applications. |
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| domaine : |
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Sciences du Vivant/Médecine humaine et pathologie/Rhumatologie et système ostéo-articulaire
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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1574-888X |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| journal : |
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| Current Stem Cell Research & Therapy |
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Bentham Science Publishers Ltd |
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| Audience : |
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internationale |
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| date de publication : |
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12/2009 |
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date de publication
électronique : |
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01/12/2009 |
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| volume : |
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4 |
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| numéro : |
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4 |
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| page, identifiant, ... : |
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318-29 |
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| Descripteur(s) MeSH : |
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Animals – Biocompatible Materials – Cartilage – Cartilage Diseases – Cell Differentiation – Chondrocytes – Guided Tissue Regeneration – Hematopoietic Stem Cell Mobilization – Humans – Intercellular Signaling Peptides and Proteins – Mesenchymal Stem Cell Transplantation – Stem Cell Niche – Tissue Engineering – Tissue Scaffolds – Animals |
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| contrat, financement : |
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This work was supported by grants from the "Fondation de l'Avenir pour la Recherche Médicale Appliquée", the "Fondation pour la Recherche Médicale", the "Arthritis-Fondation Courtin", the "Société Française de Rhumatologie", Graftys SARL and ANR "Scartifold" and ANR "Chondrograft". |
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