Cancer stem cells: Beyond Koch’s postulates - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Cancer Letters Année : 2009

Cancer stem cells: Beyond Koch’s postulates

Résumé

Until the last century, infectious diseases were the leading cause of human mortality. Therefore, our current medical reasoning is profoundly influenced by views that originated from medical microbiology. The notion that cancer growth is sustained by a sub-population of particular cells, the cancer stem cells, is highly reminiscent of the germ theory of disease as exemplified by Koch's postulates in the XIX th century. However, accumulating data underscore the importance of cell-cell interactions and tumor environment. Hence it is essential to critically review the basic tenets of the cancer stem cell concept on the light of their relationships with Koch's postulates. Shifting the pathogenic element from a special cellular entity (cancer stem cell or microorganism) to a " pathogenic field " could be critical for curing both cancer and drug-resistant infectious diseases.
Fichier principal
Vignette du fichier
Cancer Lett 2009 Jun 8 278(1) 3-8.pdf (394.12 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

inserm-01194481 , version 1 (07-09-2015)

Identifiants

Citer

Emmanuel Garcion, Philippe Naveilhan, François Berger, Didier Wion. Cancer stem cells: Beyond Koch’s postulates. Cancer Letters, 2009, 278 (1), pp.3-8. ⟨10.1016/j.canlet.2008.09.006⟩. ⟨inserm-01194481⟩
225 Consultations
667 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More