Interplay Between Human Adipocytes and T Lymphocytes in Obesity. CCL20 as an Adipochemokine and T Lymphocytes as Lipogenic Modulators.

Abstract : OBJECTIVE: Adipose tissue (AT) plays a major role in the low-grade inflammatory state associated with obesity. The aim of the present study was to characterize the human AT lymphocytes (ATLs) and to analyze their interactions with adipocytes. METHODS AND RESULTS: Human ATL subsets were characterized by flow cytometry in subcutaneous ATs from 92 individuals with body mass index (BMI) ranging from 19 to 43 kg/m(2) and in paired biopsies of subcutaneous and visceral AT from 45 class II/III obese patients. CD3(+) ATLs were composed of effector and memory CD4(+) helper and CD8(+) cytotoxic T cells. The number of ATLs correlated positively with BMI and was higher in visceral than subcutaneous AT. Mature adipocytes stimulated the migration of ATLs and released the chemokine CCL20, the receptor of which (CCR6) was expressed in ATLs. The expression of adipocyte CCL20 was positively correlated with BMI and increased in visceral compared to subcutaneous adipocytes. ATLs expressed inflammatory markers and released interferon gamma (IFNgamma). Progenitor and adipocyte treatment with ATL-conditioned media reduced the insulin-mediated upregulation of lipogenic enzymes, an effect involving IFNgamma. CONCLUSIONS: Therefore, crosstalk occurs between adipocytes and lymphocytes within human AT involving T cell chemoattraction by adipocytes and modulation of lipogenesis by ATLs.
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Article dans une revue
Arteriosclerosis, Thrombosis, and Vascular Biology, American Heart Association, 2009, epub ahead of print. 〈10.1161/ATVBAHA.109.192583〉
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http://www.hal.inserm.fr/inserm-00410481
Contributeur : Marie Francoise Simon <>
Soumis le : vendredi 21 août 2009 - 09:42:18
Dernière modification le : jeudi 9 novembre 2017 - 09:38:02

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Carine Duffaut, Alexia Zakaroff-Girard, Virginie Bourlier, Pauline Decaunes, Marie Maumus, et al.. Interplay Between Human Adipocytes and T Lymphocytes in Obesity. CCL20 as an Adipochemokine and T Lymphocytes as Lipogenic Modulators.. Arteriosclerosis, Thrombosis, and Vascular Biology, American Heart Association, 2009, epub ahead of print. 〈10.1161/ATVBAHA.109.192583〉. 〈inserm-00410481〉

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