Enhanced survival and cure of F98 glioma-bearing rats following intracerebral delivery of carboplatin in combination with photon irradiation.: Carboplatin CED and photon irradiation against glioma

Julia Rousseau 1 Caroline Boudou 2 Rolf Barth 3 Jacques Balosso 4 François Estève 4 Hélène Elleaume 4, *
* Auteur correspondant
1 INSERM U836, équipe 6, Rayonnement synchrotron et recherche médicale
GIN - Grenoble Institut des Neurosciences, ID17 - Biomedical Beamline
4 INSERM U836, équipe 6, Rayonnement synchrotron et recherche médicale
GIN - Grenoble Institut des Neurosciences, CHU Grenoble, ID17 - Biomedical Beamline
Abstract : PURPOSE: The goal of the present study was to evaluate the efficacy of intracerebral (i.c.) administration of carboplatin by means of convection-enhanced delivery (CED) in combination with fractionated, external beam photon irradiation for the treatment of F98 glioma-bearing rats. EXPERIMENTAL DESIGN: Carboplatin (20 microg/20 microL) was administrated i.c. by CED to F98 glioma-bearing rats, 13 days after stereotactic implantation of 10(3) tumor cells. One day following initiation of CED, a 24-Gy X-ray dose was administered in three daily fractions of 8 Gy each. Photon irradiation was carried out using either a conventional (6 MV) linear accelerator or a monochromatic synchrotron source (80 keV) at the European Synchrotron Radiation Facility. The primary end point of this study was overall survival. RESULTS: The median survival times were 79 and 60 days and the corresponding percent increase in life spans were 182% and 114%, respectively, for the combination of carboplatin chemotherapy and irradiation with either 6-MV or 80-keV photons. A subset of long-term survivors (>200 days) were observed in both chemoradiotherapy groups: 16.6% and 8.3% for 6 MV and 80 keV, respectively. In contrast, the median survival times for 6-MV or 80-keV irradiated controls, chemotherapy alone, and untreated controls were 42, 51, 45, and 28 days, respectively. CONCLUSIONS: Our results convincingly show the therapeutic efficacy of i.c. administration of carboplatin by means of CED in combination with either 6-MV or 80-keV photons. Further studies are warranted to optimize this combination of chemoradiotherapy for malignant gliomas.
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Article dans une revue
Clinical Cancer Research, American Association for Cancer Research, 2007, 13 (17), pp.5195-201. 〈10.1158/1078-0432.CCR-07-1002〉
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Julia Rousseau, Caroline Boudou, Rolf Barth, Jacques Balosso, François Estève, et al.. Enhanced survival and cure of F98 glioma-bearing rats following intracerebral delivery of carboplatin in combination with photon irradiation.: Carboplatin CED and photon irradiation against glioma. Clinical Cancer Research, American Association for Cancer Research, 2007, 13 (17), pp.5195-201. 〈10.1158/1078-0432.CCR-07-1002〉. 〈inserm-00410458〉

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