Integrated physiology and pathophysiology of CB1-mediated effects of the endocannabinoid system.

Abstract : The discovery of the endocannabinoid system (ECS) has raised a large interest in the scientific community providing us with a strikingly long list of apparently independent multi organ effects. As a result, in most reviews on this issue the main function of the ECS is considered as modulatory. Unfortunately, this vision does not add much to our understanding of the specific biological function of the ECS. Thus, modulatory is what in general all biological systems are or should be. In this review we will show that the apparent inconsistent puzzle of the very different tissue specific effects of endocannabinoids (ECs) can be reconstructed in one unitary picture. This picture clearly shows that all the different CB1-mediated effects of ECs sub-serve one major physiological function: to facilitate and increase energy storage. We will also analyze the implications of this unitary vision of the ECS in different contexts. First, in the context of the systems that regulate energy balance, introducing a new systematization based on two homeostatic systems: an endostatic and an exostatic system. Second, in the context of evolution, showing how the function of the ECS has shifted from essential to survival to almost pathological in current times. Finally, in a pathophysiological context, introducing the new concept of "proactive evolution diseases", which can explain the current obesity epidemic and the role the ECS plays in it.
Type de document :
Article dans une revue
Diabetes and Metabolism, Elsevier Masson, 2007, 33 (2), pp.97-107. 〈10.1016/j.diabet.2007.02.002〉
Liste complète des métadonnées

http://www.hal.inserm.fr/inserm-00409708
Contributeur : Marie Francoise Simon <>
Soumis le : mercredi 12 août 2009 - 13:44:15
Dernière modification le : jeudi 11 janvier 2018 - 06:19:05

Identifiants

Collections

Citation

Pier Vincenzo Piazza, Max Lafontan, Jean Girard. Integrated physiology and pathophysiology of CB1-mediated effects of the endocannabinoid system.. Diabetes and Metabolism, Elsevier Masson, 2007, 33 (2), pp.97-107. 〈10.1016/j.diabet.2007.02.002〉. 〈inserm-00409708〉

Partager

Métriques

Consultations de la notice

51