Partial versus radical nephrectomy in patients with adverse clinical or pathologic characteristics.

Abstract : OBJECTIVES: To assess cancer-specific survival of partial nephrectomy (PN) patients with >or= 7-cm lesions or unfavorable pathology (stage T3a or Fuhrman grades III-IV). MATERIAL AND METHODS: At 13 participation centers, 4072 partial or radical nephrectomies (RN) were performed for RCC between 1984 and 2001. Of all procedures, 925 (22.7%) were for tumors > 7 cm, 973 (23.9%) had Fuhrman grades III or IV, and 861 (21.1%) had stage pT3a. None had nodal or distant metastases. Matched (age, gender, tumor size, T stage, histologic subtype, and Fuhrman grade [FG]) survival analyses addressed the effect of nephrectomy type (partial vs radical) on cancer-specific mortality. RESULTS: Partial nephrectomy for tumors > 7 cm was associated with higher mortality than RN (HR = 5.3; P = .025). No significant cancer-specific survival differences were recorded after PN for FG III-IV (HR = 0.7, P = .5) or for pT3a lesions (HR = 2.5, P = .9). CONCLUSIONS: Partial nephrectomy may undermine cancer control in patients with tumors > 7 cm. Conversely, after PN, the same cancer control rates as after RN may be expected in patients with Fuhrman grades III-IV or with pT3a histology.
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http://www.hal.inserm.fr/inserm-00404408
Contributeur : Hervé De Villemeur <>
Soumis le : jeudi 16 juillet 2009 - 13:39:00
Dernière modification le : mercredi 16 mai 2018 - 11:23:17

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Claudio Jeldres, Jean-Jacques Patard, Umberto Capitanio, Paul Perrotte, Nazareno Suardi, et al.. Partial versus radical nephrectomy in patients with adverse clinical or pathologic characteristics.. Urology, Elsevier, 2009, 73 (6), pp.1300-5. 〈10.1016/j.urology.2008.08.492〉. 〈inserm-00404408〉

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