Angiogenesis: the VE-cadherin switch.

Abstract : Because angiogenesis is a key step in a number of pathologic processes, including tumor growth and atherosclerosis, many research studies have investigated the regulatory signals active at various stages of vascular invasion. The differential activities of the endothelial junction protein vascular endothelial (VE)-cadherin reflect the versatile behavior of endothelial cells between vascular quiescence and angiogenesis. VE-cadherin function and signaling are deeply modified in proliferating cells, and this conversion is accompanied by phosphorylation of the protein on tyrosine residues and enhanced transcription of its gene. Recent advances in the complex interplay between protein tyrosine kinases and phosphatases regulating VE-cadherin phosphorylation and function are discussed in this review.
Type de document :
Article dans une revue
Trends in Cardiovascular Medicine, Elsevier, 2006, 16 (2), pp.55-9. 〈10.1016/j.tcm.2005.11.008〉
Liste complète des métadonnées

Littérature citée [33 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00398930
Contributeur : Philippe Huber <>
Soumis le : jeudi 25 juin 2009 - 11:08:01
Dernière modification le : vendredi 26 juin 2009 - 16:05:09
Document(s) archivé(s) le : mardi 15 juin 2010 - 17:26:22

Fichiers

inserm-00398930_edited.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

CEA | UGA

Citation

Yann Wallez, Isabelle Vilgrain, Philippe Huber. Angiogenesis: the VE-cadherin switch.. Trends in Cardiovascular Medicine, Elsevier, 2006, 16 (2), pp.55-9. 〈10.1016/j.tcm.2005.11.008〉. 〈inserm-00398930〉

Partager

Métriques

Consultations de la notice

182

Téléchargements de fichiers

812