De novo and long-term l-Dopa induce both common and distinct striatal gene profiles in the hemiparkinsonian rat.

Abstract : We compared for the first time the effects of de novo versus long-term l-Dopa treatment inducing abnormal involuntary movement on striatal gene profiles and related bio-associations in the 6-hydroxydopamine rat model of Parkinson's disease. We examined the pattern of striatal messenger RNA expression over 4854 genes in hemiparkinsonian rats treated acutely or chronically with l-Dopa, and subsequently verified some of the gene alterations by in situ hybridization or real-time quantitative PCR. We found that de novo and long-term l-Dopa share common gene regulation features involving phosphorylation, signal transduction, secretion, transcription, translation, homeostasis, exocytosis and synaptic transmission processes. We also found that the transcriptomic response is enhanced by long-term l-Dopa and that specific biological alterations are underlying abnormal motor behavior. Processes such as growth, synaptogenesis, neurogenesis and cell proliferation may be particularly relevant to the long-term action of l-Dopa.
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Neurobiology of Disease, Elsevier, 2009, 34 (2), pp.340-50. 〈10.1016/j.nbd.2009.02.002〉
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http://www.hal.inserm.fr/inserm-00398614
Contributeur : Jean-Paul Issartel <>
Soumis le : mercredi 24 juin 2009 - 15:30:30
Dernière modification le : mercredi 14 février 2018 - 14:06:08

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Michèle El Atifi-Borel, Virginie Buggia-Prevot, Nadine Platet, Alim-Louis Benabid, François Berger, et al.. De novo and long-term l-Dopa induce both common and distinct striatal gene profiles in the hemiparkinsonian rat.. Neurobiology of Disease, Elsevier, 2009, 34 (2), pp.340-50. 〈10.1016/j.nbd.2009.02.002〉. 〈inserm-00398614〉

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