HCV entry and neutralizing antibodies: lessons from viral variants.

Abstract : Evaluation of: Grove J, Nielsen S, Zhong J et al.: Identification of a residue in hepatitis C virus E2 glycoprotein that determines scavenger receptor BI and CD81 receptor dependency and sensitivity to neutralizing antibodies. J. Virol. 82 (24), 12020-12029 (2008). Recent data suggest that a strong, early, broad neutralizing antibody response may contribute to the control of HCV in the acute phase of infection. However, the majority of individuals fail to clear HCV during the first months following infection and develop chronic infection despite the presence of anti-HCV antibodies. A prerequisite of the understanding behind the mechanisms of viral escape from antibody-mediated neutralization is the identification of various host-entry factors mediating the first steps of viral infection - binding and entry of HCV is believed to be a multistep process involving HCV envelope glycoproteins E1 and E2 as well as several host-cell surface molecules such as CD81, scavenger receptor class B type I, members of the claudin family and occludin. In this article, Grove et al. describe a single mutation in the HCV envelope glycoprotein E2 that alters glycoprotein structure thereby modulating viral interaction with scavenger receptor class B type I and CD81, and increasing sensitivity to neutralizing antibodies. The results of this study highlight the importance of the characterization of the interplay between HCV particles and host-cell factors for the understanding of virus neutralization by host-immune responses and pathogenesis of HCV infection.
Type de document :
Article dans une revue
Future Microbiology, Future Medicine, 2009, 4, pp.511-7. 〈10.2217/fmb.09.34〉
Liste complète des métadonnées

Littérature citée [46 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00394740
Contributeur : Thomas Baumert <>
Soumis le : samedi 12 juin 2010 - 07:00:03
Dernière modification le : dimanche 24 décembre 2017 - 01:02:07
Document(s) archivé(s) le : vendredi 17 septembre 2010 - 10:49:15

Fichiers

inserm-00394740_edited.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Mirjam Zeisel, Thomas Baumert. HCV entry and neutralizing antibodies: lessons from viral variants.. Future Microbiology, Future Medicine, 2009, 4, pp.511-7. 〈10.2217/fmb.09.34〉. 〈inserm-00394740〉

Partager

Métriques

Consultations de la notice

109

Téléchargements de fichiers

236