Metabolic control and metabolic capacity: two aspects of creatine kinase functioning in the cells.

Abstract : In this short review, the merits and limits of three theoretical concepts explaining the functional role of the creatine kinase system in muscle and brain cells are analysed. In addition to the usual concept of an energy buffer system and the recently proposed metabolic capacity theory (Sweeney, H.L. (1994) Med. Sci. Sports Exerc. 26, 30-36), it is proposed that coupled creatine kinase systems are involved in effective metabolic regulation of energy fluxes and oxidative phosphorylation, beside their energy transfer function. This aspect of the system is considered on the basis of metabolic control analysis. It is shown by using the results of mathematical modelling that, due to amplification of ADP fluxes from the cytoplasm by the mechanism of metabolic channelling, coupled mitochondrial creatine kinase may exert a flux control coefficient significantly exceeding 1.
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Article dans une revue
BBA - Molecular Cell Research, Elsevier, 1996, 1274 (3), pp.81-8
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http://www.hal.inserm.fr/inserm-00391366
Contributeur : Sarah Hamant <>
Soumis le : mercredi 3 juin 2009 - 17:53:45
Dernière modification le : jeudi 9 février 2017 - 15:56:45

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  • HAL Id : inserm-00391366, version 1
  • PUBMED : 8664307

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Valdur Saks, Renée Ventura-Clapier, Mayis Aliev. Metabolic control and metabolic capacity: two aspects of creatine kinase functioning in the cells.. BBA - Molecular Cell Research, Elsevier, 1996, 1274 (3), pp.81-8. 〈inserm-00391366〉

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