Assessment of iodohexadecenoic acid as a tracer of fatty acid metabolism by external detection: a study on isolated rat heart.

Abstract : Labelled fatty acids have been proposed to explore cardiac metabolism. For the analysis of the external detection curve obtained with 16-iodo 9-hexadecenoic acid (IHA), we developed a mathematical 4-compartment model with compartments 0, 1, 2 and 3 representing vascular IHA, intracellular IHA, esterified forms and iodide, respectively. This model, used here for isolated rat hearts perfused in a recirculating system, is validated by an intracellular analysis, then tested in various metabolic conditions. Thus, the mathematical analysis of the external detection curve gives us numerical data on IHA metabolism, especially the distribution between degradation and storage. Our results confirm the suitability of IHA for assessing myocardial metabolism.
Type de document :
Article dans une revue
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, Elsevier, 1992, 19 (3), pp.349-55
Liste complète des métadonnées

http://www.hal.inserm.fr/inserm-00390268
Contributeur : Sarah Hamant <>
Soumis le : lundi 1 juin 2009 - 14:28:57
Dernière modification le : jeudi 11 janvier 2018 - 06:22:44

Identifiants

  • HAL Id : inserm-00390268, version 1
  • PUBMED : 1629024

Collections

UGA

Citation

Christiane Keriel, F. M. Dubois, D. S. Marti Batlle, C. R. Pernin, Xavier Leverve, et al.. Assessment of iodohexadecenoic acid as a tracer of fatty acid metabolism by external detection: a study on isolated rat heart.. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, Elsevier, 1992, 19 (3), pp.349-55. 〈inserm-00390268〉

Partager

Métriques

Consultations de la notice

590