Relationships between age-dependent changes in the effect of almitrine on H(+)-ATPase/ATPsynthase and the pattern of membrane fatty acid composition.

Abstract : The effects of almitrine on ATPase/ATPsynthase previously described in beef heart mitochondria (Rigoulet et al. (1990) Biochim. Biophys. Acta 1018, 91-97) are also observed in liver mitochondria isolated from rats older than 7 weeks. In contrast, in rats younger than 5 weeks, almitrine at the same concentration has no effect on the ATPase/ATPsynthase complex. This age-dependent action of almitrine is well correlated with age-dependent modifications of two fatty acids: linoleic and docosahexaenoic acids. The possibility of a change in H+/ATP stoichiometry of the ATPase/ATPsynthase induced by almitrine seems related to more general modifications of membrane properties during growth of the rat.
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Article dans une revue
BBA - Molecular Cell Research, Elsevier, 1993, 1141 (1), pp.90-4
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Soumis le : lundi 1 juin 2009 - 14:14:44
Dernière modification le : jeudi 11 janvier 2018 - 06:15:31

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  • HAL Id : inserm-00390264, version 1
  • PUBMED : 8435438

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Muriel Jumelle-Laclau, Michel Rigoulet, Nicole Averet, Xavier Leverve, Lilliane Dubourg, et al.. Relationships between age-dependent changes in the effect of almitrine on H(+)-ATPase/ATPsynthase and the pattern of membrane fatty acid composition.. BBA - Molecular Cell Research, Elsevier, 1993, 1141 (1), pp.90-4. 〈inserm-00390264〉

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