Sodium lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain-injured patients.

Abstract : OBJECTIVES: Traumatic brain injury (TBI) is still a major cause of mortality and morbidity. Recent trials have failed to demonstrate a beneficial outcome from therapeutic treatments such as corticosteroids, hypothermia and hypertonic saline. We investigated the effect of a new hyperosmolar solution based on sodium lactate in controlling raised intracranial pressure (ICP). DESIGN AND SETTING: Prospective open randomized study in an adult ICU. PATIENTS: Thirty-four patients with isolated severe TBI (Glasgow Coma Scale
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Annales Françaises d'Anesthésie et de Réanimation, Elsevier Masson, 2009, 35 (3), pp.471-9. 〈10.1007/s00134-008-1283-5〉
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Soumis le : mardi 26 mai 2009 - 21:09:04
Dernière modification le : jeudi 11 janvier 2018 - 16:37:58

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Carole Ichai, Guy Armando, Jean-Christophe Orban, Fréderic Berthier, Laurent Rami, et al.. Sodium lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain-injured patients.. Annales Françaises d'Anesthésie et de Réanimation, Elsevier Masson, 2009, 35 (3), pp.471-9. 〈10.1007/s00134-008-1283-5〉. 〈inserm-00388527〉

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