High expression of thyroid hormone receptors and mitochondrial glycerol-3-phosphate dehydrogenase in the liver is linked to enhanced fatty acid oxidation in Lou/C, a rat strain resistant to obesity.

Abstract : Besides its well recognized role in lipid and carbohydrate metabolisms, glycerol is involved in the regulation of cellular energy homeostasis via glycerol-3-phosphate, a key metabolite in the translocation of reducing power across the mitochondrial inner membrane with mitochondrial glycerol-3-phosphate dehydrogenase. Here, we report a high rate of gluconeogenesis from glycerol and fatty acid oxidation in hepatocytes from Lou/C, a peculiar rat strain derived from Wistar, which is resistant to age- and diet-related obesity. This feature, associated with elevated cellular respiration and cytosolic ATP/ADP and NAD(+)/NADH ratios, was linked to a high expression and activity of mitochondrial glycerol-3-phosphate dehydrogenase. Interestingly, this strain exhibited high expression and protein content of thyroid hormone receptor, whereas circulating thyroid hormone levels were slightly decreased and hepatic thyroid hormone carrier MCT-8 mRNA levels were not modified. We propose that an enhanced liver thyroid hormone receptor in Lou/C may explain its unique resistance to obesity by increasing fatty acid oxidation and lowering liver oxidative phosphorylation stoichiometry at the translocation of reducing power into mitochondria.
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Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2009, 284 (7), pp.4308-16. 〈10.1074/jbc.M806187200〉
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Soumis le : mardi 26 mai 2009 - 19:37:20
Dernière modification le : jeudi 28 mai 2009 - 09:57:49

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Nellie Taleux, Bruno Guigas, Hervé Dubouchaud, Maria Moreno, Joachim Weitzel, et al.. High expression of thyroid hormone receptors and mitochondrial glycerol-3-phosphate dehydrogenase in the liver is linked to enhanced fatty acid oxidation in Lou/C, a rat strain resistant to obesity.. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2009, 284 (7), pp.4308-16. 〈10.1074/jbc.M806187200〉. 〈inserm-00388518〉

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