[Lifespan and IGF receptors in the brain.]

Abstract : Using a mouse model relevant for humans, lifespan can be prolonged by reducing IGF-I signaling selectively in the central nervous system. This effect occurred through changes in specific neuroendocrine pathways. Investigating the pathophysiological mechanism, we found that IGF receptors in the brain steered the development of the somatotropic axis, which in turn altered the individual growth trajectory and lifespan. Our work is experimental proof that chronically low IGF-I and low growth hormone (GH) levels favor long lifespan and postpone age-related mortality. Our results, together with other recent reports, challenge the notion that GH can slow down or prevent human aging. This is important because growth hormone is sometimes poposed to elderly people as a substitutive treatment in order to compensate the negative effects of aging. double dagger.
Type de document :
Article dans une revue
médecine/sciences, EDP Sciences, 2009, 25 (4), pp.371-6
Liste complète des métadonnées

Littérature citée [33 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00384980
Contributeur : Delphine Autard <>
Soumis le : jeudi 1 octobre 2009 - 10:11:25
Dernière modification le : mercredi 21 mars 2018 - 18:57:25
Document(s) archivé(s) le : jeudi 10 juin 2010 - 23:19:35

Fichier

HolzenbergerMedSci09.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

  • HAL Id : inserm-00384980, version 1
  • PUBMED : 19409189

Collections

Citation

Martin Holzenberger. [Lifespan and IGF receptors in the brain.]. médecine/sciences, EDP Sciences, 2009, 25 (4), pp.371-6. 〈inserm-00384980〉

Partager

Métriques

Consultations de la notice

166

Téléchargements de fichiers

500