Fluctuation of the SP/non-SP phenotype in the C6 glioma cell line.
Abstract
Using the C6 glioma cell as a paradigm, we found that (i) the clonogenicity of C6 cells is several orders of magnitude higher than the percentage of SP cells; (ii) non-SP cells are able to generate SP cells, and conversely SP cells generate non-SP cells; (iii) non-SP sorted cells behave as tumorigenic cells. Hence, in C6 cells cultured in serum-containing medium, SP cells can be generated from non-SP cells. This dynamic equilibrium explains in C6 cells the maintenance of the SP phenotype with cell passaging and demonstrates the existence of tumorigenic non-SP cells.
Domains
Cancer
Fichier principal
Fluctuations.pdf (391.44 Ko)
Télécharger le fichier
inserm-00383790_edited.pdf (1.19 Mo)
Télécharger le fichier
Origin : Files produced by the author(s)
Origin : Files produced by the author(s)
Loading...